Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice

• Published in: Science (American Association for the Advancement of Science) Vol. 359; no. 6382; pp. 1403 - 1407
• Main Authors: Pereira, Ethel R., Kedrin, Dmitriy, Seano, Giorgio, Gautier, Olivia, Meijer, Eelco F. J., Jones, Dennis, Chin, Shan-Min, Kitahara, Shuji, Bouta, Echoe M., Chang, Jonathan, Beech, Elizabeth, Jeong, Han-Sin, Carroll, Michael C., Taghian, Alphonse G., Padera, Timothy P.
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 23.03.2018
• Subjects: Animal models; Animals; Biopsy; Blood circulation; Blood vessels; Blood Vessels - pathology; Breast cancer; Cancer; Carcinoma; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Tracking - methods; Cytosol - chemistry; Female; Luminescent Proteins - analysis; Lung - pathology; Lungs; Lymph; Lymph nodes; Lymph Nodes - pathology; Lymphatic Metastasis - pathology; Lymphatic system; Mammary gland; Mastectomy; Melanoma; Melanoma, Experimental; Metastases; Metastasis; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Seeding; Neoplastic Cells, Circulating; Organs; Patients; Prognosis; Squamous cell carcinoma; Tumor cells; Tumors

Metastatic tumor cells are thought to reach distant organs by traveling through the blood circulation or the lymphatic system. Two studies of mouse models now suggest a hybrid route for tumor cell dissemination. Pereira et al. and Brown et al. used distinct methodologies to monitor the fate of tumor...