Zika virus infection enhances future risk of severe dengue disease

• Published in: Science (American Association for the Advancement of Science) Vol. 369; no. 6507; pp. 1123 - 1128
• Main Authors: Katzelnick, Leah C., Narvaez, César, Arguello, Sonia, Lopez Mercado, Brenda, Collado, Damaris, Ampie, Oscarlett, Elizondo, Douglas, Miranda, Tatiana, Bustos Carillo, Fausto, Mercado, Juan Carlos, Latta, Krista, Schiller, Amy, Segovia-Chumbez, Bruno, Ojeda, Sergio, Sanchez, Nery, Plazaola, Miguel, Coloma, Josefina, Halloran, M. Elizabeth, Premkumar, Lakshmanane, Gordon, Aubree, Narvaez, Federico, de Silva, Aravinda M., Kuan, Guillermina, Balmaseda, Angel, Harris, Eva
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 28.08.2020
• Subjects: Antibodies; Antibodies, Viral - blood; Dengue fever; Dengue hemorrhagic fever; Dengue Vaccines - immunology; Dengue Virus - immunology; Epidemics; Homology; Humans; Immunity; Immunogenicity, Vaccine; Infections; Nicaragua - epidemiology; Pandemics; Pediatrics; Risk; Serogroup; Serotypes; Severe Dengue - epidemiology; Vaccines; Vector-borne diseases; Viral envelope proteins; Viruses; Zika virus; Zika Virus - immunology; Zika Virus Infection - epidemiology; Zika Virus Infection - immunology; Nicaragua

Dengue and Zika virus epidemics have been lapping each other around the globe. These are closely related mosquito-borne viruses with about 40% homology within the envelope protein. We know that subsequent dengue infections bring a risk of antibody-dependent disease enhancement. Whereas emphasis has...