Update on the Management of Breast Cancer during Pregnancy

The diagnosis of breast cancer during pregnancy represents a challenging situation for the patient, her caregivers and physicians. Pregnancy adds complexity to oncological treatment planning, as many therapies can be potentially dangerous to the fetus. Therefore, a multidisciplinary approach is need...

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Published inCancers Vol. 12; no. 12; p. 3616
Main Authors Poggio, Francesca, Tagliamento, Marco, Pirrone, Chiara, Soldato, Davide, Conte, Benedetta, Molinelli, Chiara, Cosso, Maurizio, Fregatti, Piero, Del Mastro, Lucia, Lambertini, Matteo
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 03.12.2020
MDPI
Subjects
Antitumor agents
Biology
Biopsy
Breast cancer
Cancer therapies
Chemotherapy
Contraindications
Cytotoxicity
Drug dosages
Endocrine therapy
Fetuses
Genomes
Gestational age
Lymphatic system
Medical prognosis
Mutation
Patients
Pregnancy
Radiation therapy
Review
Surgery
Womens health
targeted therapy
pregnancy during breast cancer
immunotherapy
pregnancy
radiotherapy
breast cancer
chemotherapy
endocrine therapy
surgery
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Abstract The diagnosis of breast cancer during pregnancy represents a challenging situation for the patient, her caregivers and physicians. Pregnancy adds complexity to oncological treatment planning, as many therapies can be potentially dangerous to the fetus. Therefore, a multidisciplinary approach is needed to offer a proper care for obtaining the best possible outcomes for the mother and the future child. Breast surgery is feasible throughout the pregnancy while radiotherapy should be postponed after delivery. Administration of chemotherapy is considered safe and can be given during the second and third trimesters, while it is contraindicated in the first trimester due to the high risk of fetal malformations. Endocrine therapy and targeted agents are not recommended during the whole pregnancy period; however, limited data are available on the use of the majority of new anticancer drugs in this context. The aim of the current review is to provide an update on the current state of art about the management of women diagnosed with breast cancer during pregnancy.
AbstractList The diagnosis of breast cancer during pregnancy represents a challenging situation for the patient, her caregivers and physicians. Pregnancy adds complexity to oncological treatment planning, as many therapies can be potentially dangerous to the fetus. Therefore, a multidisciplinary approach is needed to offer a proper care for obtaining the best possible outcomes for the mother and the future child. Breast surgery is feasible throughout the pregnancy while radiotherapy should be postponed after delivery. Administration of chemotherapy is considered safe and can be given during the second and third trimesters, while it is contraindicated in the first trimester due to the high risk of fetal malformations. Endocrine therapy and targeted agents are not recommended during the whole pregnancy period; however, limited data are available on the use of the majority of new anticancer drugs in this context. The aim of the current review is to provide an update on the current state of art about the management of women diagnosed with breast cancer during pregnancy.
Author Lambertini, Matteo
Pirrone, Chiara
Cosso, Maurizio
Molinelli, Chiara
Poggio, Francesca
Del Mastro, Lucia
Soldato, Davide
Tagliamento, Marco
Conte, Benedetta
Fregatti, Piero
AuthorAffiliation 2 U.O. Oncologia Medica 2, Medical Oncology Department, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy; tagliamento.marco@gmail.com (M.T.); chiara.pirrone.92@gmail.com (C.P.); davide.soldato@gmail.com (D.S.); bntconte@gmail.com (B.C.); chiara.molinelli91@gmail.com (C.M.)
6 Department of Integrated Diagnostic Surgical Sciences, School of Medicine, University of Genova, 16132 Genova, Italy
1 Breast Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy; francescabenedetta.poggio@hsanmartino.it (F.P.); lucia.delmastro@hsanmartino.it (L.D.M.)
7 U.O.C. Clinica di Oncologia Medica, Medical Oncology Department, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy
4 Department of Radiology, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy; maurizio.cosso@hsanmartino.it
5 U.O.C. Clinica di Chirurgia Senologica, Department of Surgery, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy; piero.fregatti@unige.it
3 Department of Internal Medicine and Medi
AuthorAffiliation_xml – name: 3 Department of Internal Medicine and Medical Specialties (DiMI), School of Medicine, University of Genova, 16132 Genova, Italy
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– name: 7 U.O.C. Clinica di Oncologia Medica, Medical Oncology Department, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy
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– name: 5 U.O.C. Clinica di Chirurgia Senologica, Department of Surgery, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy; piero.fregatti@unige.it
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/33287242$$D View this record in MEDLINE/PubMed
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Issue 12
Keywords targeted therapy
pregnancy during breast cancer
immunotherapy
pregnancy
radiotherapy
breast cancer
chemotherapy
endocrine therapy
surgery
Language English
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Snippet The diagnosis of breast cancer during pregnancy represents a challenging situation for the patient, her caregivers and physicians. Pregnancy adds complexity to...
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StartPage 3616
SubjectTerms Antitumor agents
Biology
Biopsy
Breast cancer
Cancer therapies
Chemotherapy
Contraindications
Cytotoxicity
Drug dosages
Endocrine therapy
Fetuses
Genomes
Gestational age
Lymphatic system
Medical prognosis
Mutation
Patients
Pregnancy
Radiation therapy
Review
Surgery
Womens health
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Title Update on the Management of Breast Cancer during Pregnancy
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Volume 12
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