Functional Remodeling of the Contractile Smooth Muscle Cell Cortex, a Provocative Concept, Supported by Direct Visualization of Cortical Remodeling

• Published in: Biology (Basel, Switzerland) Vol. 11; no. 5; p. 662
• Main Authors: Suphamungmee, Worawit, Lehman, William, Morgan, Kathleen G
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.04.2022; MDPI
• Subjects: Actin; Actinin; Adaptor proteins; Adhesion; Cardiovascular disease; Cell size; Chemical stimuli; Cytoplasm; Cytoskeleton; Extracellular matrix; Fibroblasts; Filaments; Functional anatomy; Immunoelectron microscopy; Interfaces; Kinases; Mechanotransduction; Microscopy; Muscle contraction; Myosin; Phenylephrine; Polymerization; Proteins; Review; Signal transduction; Smooth muscle; Talin; vascular smooth muscle; zyxin; actin; immunoelectron microscopy; vascular smooth muscle; talin; zyxin

Considerable controversy has surrounded the functional anatomy of the cytoskeleton of the contractile vascular smooth muscle cell. Recent studies have suggested a dynamic nature of the cortical cytoskeleton of these cells, but direct proof has been lacking. Here, we review past studies in this area...