Exploring Interactions between Primary Hepatocytes and Non-Parenchymal Cells on Physiological and Pathological Liver Stiffness

• Published in: Biology (Basel, Switzerland) Vol. 10; no. 5; p. 408
• Main Authors: Natarajan, Vaishaali, Moeun, Youra, Kidambi, Srivatsan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 05.05.2021; MDPI
• Subjects: biomimetic models; Blood pressure; Cell interactions; cell–cell interaction; Cirrhosis; coculture; Collagen; Cytochrome P450; E-cadherin; Enzymatic activity; Etiology; Fibroblasts; Fibrosis; Genotype & phenotype; Glucose; Hepatocytes; Liver cirrhosis; Liver diseases; liver stiffness; Mechanical properties; Phenotypes; Physiology; Plasma; Polydimethylsiloxane; Urea; United States > US; biomimetic models; liver stiffness; coculture; cell–cell interaction; hepatocytes

Chronic liver disease is characterized by progressive hepatic fibrosis leading to the formation of cirrhosis irrespective of the etiology with no effective treatment currently available. Liver stiffness (LS) is currently the best clinical predictor of this fibrosis progression irrespective of the et...