Increased binding of peripheral benzodiazepine receptor in mild cognitive impairment–dementia converters measured by positron emission tomography with [11C]DAA1106

• Published in: Psychiatry research. Neuroimaging Vol. 203; no. 1; pp. 67 - 74
• Main Authors: Yasuno, Fumihiko, Kosaka, Jun, Ota, Miho, Higuchi, Makoto, Ito, Hiroshi, Fujimura, Yota, Nozaki, Shoko, Takahashi, Sho, Mizukami, Katsuyoshi, Asada, Takashi, Suhara, Tetsuya
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 30.07.2012; Elsevier
• Subjects: [11C]DAA1106; Acetamides; Adult and adolescent clinical studies; Aged; Alzheimer Disease - diagnosis; Alzheimer Disease - metabolism; Alzheimer's disease (AD); Biological and medical sciences; Brain - diagnostic imaging; Brain - metabolism; Case-Control Studies; Cognitive Dysfunction - diagnosis; Cognitive Dysfunction - metabolism; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Disease Progression; Female; Follow-Up Studies; Geriatrics; Humans; Male; Medical sciences; Microglia; Microglia - diagnostic imaging; Microglia - metabolism; Middle Aged; Mild cognitive impairment (MCI); Neurology; Organic mental disorders. Neuropsychology; Peripheral benzodiazepine receptor (PBR); Phenyl Ethers; Positron emission tomography; Prognosis; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Radioligand Assay; Radiology; Radiopharmaceuticals; Receptors, GABA - metabolism; Alzheimer's disease (AD); [11C]DAA1106; Positron emission tomography; Mild cognitive impairment (MCI); Peripheral benzodiazepine receptor (PBR); Microglia; [ 11C]DAA1106; Radionuclide study; Human; Peripheral benzodiazepine receptor; Nervous system diseases; Cognitive disorder; C]DAA1106; Alzheimer disease; Neuroglia; Cerebral disorder; Central nervous system disease; Degenerative disease; mild cognitive impairment; [; Emission tomography

Subjects with mild cognitive impairment (MCI) have “prodromal or incipient” dementia with neuropathological changes. Peripheral benzodiazepine receptor (PBR) binding was shown to reflect activated microglia, one of the predictive biomarkers of conversion to dementia. We sought to evaluate PBR bindin...