The Revolutionary Roads to Study Cell-Cell Interactions in 3D In Vitro Pancreatic Cancer Models

Pancreatic cancer, the fourth most common cancer worldwide, shows a highly unsuccessful therapeutic response. In the last 10 years, neither important advancements nor new therapeutic strategies have significantly impacted patient survival, highlighting the need to pursue new avenues for drug develop...

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Bibliographic Details
Published inCancers Vol. 13; no. 4; p. 930
Main Authors Delle Cave, Donatella, Rizzo, Riccardo, Sainz, Jr, Bruno, Gigli, Giuseppe, Del Mercato, Loretta L, Lonardo, Enza
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 23.02.2021
MDPI
Subjects
3D cultures
Cancer therapies
Cell growth
Cell interactions
Clinical trials
Collagen
CRISPR
Cytokines
Drug development
Drug testing
Extracellular matrix
Fibroblasts
fluorescent microscopy
Gene expression
Growth factors
nanotechnology
Pancreatic cancer
Physiology
predictive models
Review
Spheroids
Stem cells
tumor microenvironment
Tumors
fluorescent microscopy
nanotechnology
pancreatic cancer
tumor microenvironment
predictive models
3D cultures
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Summary:Pancreatic cancer, the fourth most common cancer worldwide, shows a highly unsuccessful therapeutic response. In the last 10 years, neither important advancements nor new therapeutic strategies have significantly impacted patient survival, highlighting the need to pursue new avenues for drug development discovery and design. Advanced cellular models, resembling as much as possible the original in vivo tumor environment, may be more successful in predicting the efficacy of future anti-cancer candidates in clinical trials. In this review, we discuss novel bioengineered platforms for anticancer drug discovery in pancreatic cancer, from traditional two-dimensional models to innovative three-dimensional ones.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13040930