Validation of semi-quantitative methods for DAT SPECT: influence of anatomical variability and partial volume effect

• Published in: Physics in medicine & biology Vol. 60; no. 15; pp. 5925 - 5938
• Main Authors: Gallego, J, Niñerola-Baizán, A, Cot, A, Aguiar, P, Crespo, C, Falcón, C, Lomeña, F, Sempau, J, Pavía, J, Ros, D
• Format: Journal Article Publication
• Language: English
• Published: England IOP Publishing 07.08.2015
• Subjects: Algorismes; Algorithms; Data Interpretation, Statistical; Dopamine Plasma Membrane Transport Proteins - metabolism; Electromagnetisme; Física; Humans; I]FP-bib SPECT; Iodine Radioisotopes - pharmacokinetics; Magnetic resonance; Magnetisme; Matemàtiques i estadística; Monte Carlo Method; Monte Carlo simulation; Montecarlo, Mètode de; Neostriatum - diagnostic imaging; Radiopharmaceuticals - pharmacokinetics; Ressonància magnètica; standardization; Tomography, Emission-Computed, Single-Photon - methods; Tropanes - pharmacokinetics; Àrees temàtiques de la UPC

The aim of this work was to evaluate the influence of anatomical variability between subjects and of the partial volume effect (PVE) on the standardized Specific Uptake Ratio (SUR) in [123I]FP-bib SPECT studies. To this end, magnetic resonance (MR) images of 23 subjects with differences in the stria...