WRN -Mutated Colorectal Cancer Is Characterized by a Distinct Genetic Phenotype

• Published in: Cancers Vol. 12; no. 5; p. 1319
• Main Authors: Zimmer, Kai, Puccini, Alberto, Xiu, Joanne, Baca, Yasmine, Spizzo, Gilbert, Lenz, Heinz-Josef, Battaglin, Francesca, Goldberg, Richard M, Grothey, Axel, Shields, Anthony F, Salem, Mohamed E, Marshall, John L, Korn, W Michael, Wolf, Dominik, Kocher, Florian, Seeber, Andreas
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.05.2020; MDPI
• Subjects: Adenomatous polyposis coli; BRCAness; Cancer; Cell cycle; Colorectal cancer; Colorectal carcinoma; Deoxyribonucleic acid; DNA; DNA methylation; DNA repair; Genes; Genomic instability; Genomics; Genotype & phenotype; Hybridization; Immune checkpoint; Immunohistochemistry; Medical prognosis; Metastasis; Microsatellite instability; Mismatch repair; Missense mutation; MSI-H/dMMR; Mutation; Next-generation sequencing; p53 Protein; PD-L1; PD-L1 protein; Phenotypes; Proteomics; Studies; TMB; Tumors; Werner's syndrome; WRN; WRN; colorectal cancer; immunotherapy; MSI-H/dMMR; PD-L1; TMB; BRCAness; molecular profiling

Werner syndrome gene ( ) contributes to DNA repair. In cancer, mutations ( -mut) lead to genomic instability. Thus, is a promising target in cancers with microsatellite instability (MSI). We assessed this study to investigate the molecular profile of -mut in colorectal cancer (CRC). Tumor samples we...