Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

• Published in: Science (American Association for the Advancement of Science) Vol. 359; no. 6378; pp. 920 - 926
• Main Authors: Vlachogiannis, Georgios, Hedayat, Somaieh, Vatsiou, Alexandra, Jamin, Yann, Fernández-Mateos, Javier, Khan, Khurum, Lampis, Andrea, Eason, Katherine, Huntingford, Ian, Burke, Rosemary, Rata, Mihaela, Koh, Dow-Mu, Tunariu, Nina, Collins, David, Hulkki-Wilson, Sanna, Ragulan, Chanthirika, Spiteri, Inmaculada, Moorcraft, Sing Yu, Chau, Ian, Rao, Sheela, Watkins, David, Fotiadis, Nicos, Bali, Maria, Darvish-Damavandi, Mahnaz, Lote, Hazel, Eltahir, Zakaria, Smyth, Elizabeth C., Begum, Ruwaida, Clarke, Paul A., Hahne, Jens C., Dowsett, Mitchell, de Bono, Johann, Workman, Paul, Sadanandam, Anguraj, Fassan, Matteo, Sansom, Owen J., Eccles, Suzanne, Starling, Naureen, Braconi, Chiara, Sottoriva, Andrea, Robinson, Simon P., Cunningham, David, Valeri, Nicola
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 23.02.2018
• Subjects: Animal models; Animals; Anticancer properties; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Antitumor agents; Cancer; Cell culture; Clinical trials; Drug Resistance, Neoplasm; Drug screening; Feedback (Response); Gastrointestinal Neoplasms - drug therapy; Gastrointestinal Neoplasms - pathology; Genomics; Humans; Mathematical models; Medical research; Metastases; Metastasis; Mice; Neoplasm Metastasis; Organoids; Organoids - drug effects; Organoids - metabolism; Patients; Phenylurea Compounds - pharmacology; Phenylurea Compounds - therapeutic use; Precision medicine; Precision Medicine - methods; Pyridines - pharmacology; Pyridines - therapeutic use; Screening; Three dimensional models; Tumors; Xenograft Model Antitumor Assays; Xenografts; Xenotransplantation

Cancer organoids are miniature, three-dimensional cell culture models that can be made from primary patient tumors and studied in the laboratory. Vlachogiannis et al. asked whether such “tumor-in-a-dish” approaches can be used to predict drug responses in the clinic. They generated a live organoid b...