Patient-derived organoids model treatment response of metastatic gastrointestinal cancers - Vlachogiannis, Georgios; Hedayat, Somaieh; Vatsiou, Alexandra; Jamin, Yann; Fernández-Mateos, Javier; Khan, Khurum; Lampis, Andrea; Eason, Katherine; Huntingford, Ian; Burke, Rosemary; Rata, Mihaela; Koh, Dow-Mu; et al. (Science (American Association for the Advancement of Science), 2018)
Keywords: Animal models; Animals; Anticancer properties; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Antitumor agents; Cancer; Cell culture; Clinical trials; Drug Resistance, Neoplasm; Drug screening; Feedback (Response); Gastrointestinal Neoplasms - drug therapy; Gastrointestinal Neoplasms - pathology; Genomics; Humans; Mathematical models; Medical research; Metastases; Metastasis; Mice; Neoplasm Metastasis; Organoids; Organoids - drug effects; Organoids - metabolism; Patients; Phenylurea Compounds - pharmacology; Phenylurea Compounds - therapeutic use; Precision medicine; Precision Medicine - methods; Pyridines - pharmacology; Pyridines - therapeutic use; Screening; Three dimensional models; Tumors; Xenograft Model Antitumor Assays; Xenografts; Xenotransplantation