Mutation of foxl2 or cyp19a1a Results in Female to Male Sex Reversal in XX Nile Tilapia

• Published in: Endocrinology (Philadelphia) Vol. 158; no. 8; pp. 2634 - 2647
• Main Authors: Zhang, Xianbo, Li, Mengru, Ma, He, Liu, Xingyong, Shi, Hongjuan, Li, Minghui, Wang, Deshou
• Format: Journal Article
• Language: English
• Published: Washington, DC Endocrine Society 01.08.2017; Oxford University Press
• Subjects: 17β-Estradiol; Aldosterone synthase; Androgens - biosynthesis; Animals; Aromatase; Aromatase - genetics; Aromatase - metabolism; Cell number; Cichlids - genetics; Cichlids - physiology; Endocrinology; Enzymes; Estradiol - pharmacology; Estrogens; Female; Females; Fish; Forkhead protein; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - metabolism; Functionals; Gene Deletion; Gene expression; Gene Expression Regulation - drug effects; Germ cells; Gonads; Hatching; Male; Males; Mutants; Mutation; Oreochromis niloticus; Ovaries; Phenotypes; Sex Characteristics; Sex Differentiation - genetics; Sex hormones; Sex reversal; Tilapia; Transcription; Up-regulation; Vertebrates; Zebrafish

Abstract It is well accepted that Forkhead box protein L2 (Foxl2) and aromatase (Cyp19a1; the enzyme responsible for estrogen synthesis) are critical for ovarian development in vertebrates. Knockouts of Foxl2 and Cyp19a1 in goat, mouse, and zebrafish have revealed similar but not identical functions...