The protective effect of glibenclamide in a model of hemorrhagic encephalopathy of prematurity

• Published in: Brain sciences Vol. 3; no. 1; pp. 215 - 238
• Main Authors: Tosun, Cigdem, Koltz, Michael T, Kurland, David B, Ijaz, Hina, Gurakar, Melda, Schwartzbauer, Gary, Coksaygan, Turhan, Ivanova, Svetlana, Gerzanich, Volodymyr, Simard, J Marc
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 07.03.2013; MDPI
• Subjects: choroid plexus hemorrhage; Encephalitis; encephalopathy of prematurity; germinal matrix hemorrhage; glibenclamide; Hemorrhage; intraventricular hemorrhage; Ischemia; Neurology; sulfonylurea receptor 1; germinal matrix hemorrhage; intraventricular hemorrhage; sulfonylurea receptor 1; encephalopathy of prematurity; glibenclamide; choroid plexus hemorrhage

We studied a model of hemorrhagic encephalopathy of prematurity (EP) that closely recapitulates findings in humans with hemorrhagic EP. This model involves tandem insults of 20 min intrauterine ischemia (IUI) plus an episode of elevated venous pressure induced by intraperitoneal glycerol on post-nat...