The protective effect of glibenclamide in a model of hemorrhagic encephalopathy of prematurity

We studied a model of hemorrhagic encephalopathy of prematurity (EP) that closely recapitulates findings in humans with hemorrhagic EP. This model involves tandem insults of 20 min intrauterine ischemia (IUI) plus an episode of elevated venous pressure induced by intraperitoneal glycerol on post-nat...

Full description

Saved in:
Bibliographic Details
Published inBrain sciences Vol. 3; no. 1; pp. 215 - 238
Main Authors Tosun, Cigdem, Koltz, Michael T, Kurland, David B, Ijaz, Hina, Gurakar, Melda, Schwartzbauer, Gary, Coksaygan, Turhan, Ivanova, Svetlana, Gerzanich, Volodymyr, Simard, J Marc
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 07.03.2013
MDPI
Subjects
choroid plexus hemorrhage
Encephalitis
encephalopathy of prematurity
germinal matrix hemorrhage
glibenclamide
Hemorrhage
intraventricular hemorrhage
Ischemia
Neurology
sulfonylurea receptor 1
germinal matrix hemorrhage
intraventricular hemorrhage
sulfonylurea receptor 1
encephalopathy of prematurity
glibenclamide
choroid plexus hemorrhage
Online AccessGet full text

Cover

Abstract We studied a model of hemorrhagic encephalopathy of prematurity (EP) that closely recapitulates findings in humans with hemorrhagic EP. This model involves tandem insults of 20 min intrauterine ischemia (IUI) plus an episode of elevated venous pressure induced by intraperitoneal glycerol on post-natal day (P) 0. We examined Sur1 expression, which is upregulated after focal ischemia but has not been studied after brief global ischemia including IUI. We found that 20 min IUI resulted in robust upregulation of Sur1 in periventricular microvessels and tissues. We studied tandem insult pups from untreated or vehicle-treated dams (TI-CTR), and tandem insult pups from dams administered a low-dose, non-hypoglycemogenic infusion of the Sur1 blocker, glibenclamide, for 1 week after IUI (TI-GLIB). Compared to pups from the TI-CTR group, pups from the TI-GLIB group had significantly fewer and less severe hemorrhages on P1, performed significantly better on the beam walk and accelerating Rotarod on P35 and in tests of thigmotaxis and rapid learning on P35-49, and had significantly greater body and brain weights at P52. We conclude that low-dose glibenclamide administered to the mother at the end of pregnancy protects pups subjected to IUI from post-natal events of elevated venous pressure and its consequences.
AbstractList We studied a model of hemorrhagic encephalopathy of prematurity (EP) that closely recapitulates findings in humans with hemorrhagic EP. This model involves tandem insults of 20 min intrauterine ischemia (IUI) plus an episode of elevated venous pressure induced by intraperitoneal glycerol on post-natal day (P) 0. We examined Sur1 expression, which is upregulated after focal ischemia but has not been studied after brief global ischemia including IUI. We found that 20 min IUI resulted in robust upregulation of Sur1 in periventricular microvessels and tissues. We studied tandem insult pups from untreated or vehicle-treated dams (TI-CTR), and tandem insult pups from dams administered a low-dose, non-hypoglycemogenic infusion of the Sur1 blocker, glibenclamide, for 1 week after IUI (TI-GLIB). Compared to pups from the TI-CTR group, pups from the TI-GLIB group had significantly fewer and less severe hemorrhages on P1, performed significantly better on the beam walk and accelerating Rotarod on P35 and in tests of thigmotaxis and rapid learning on P35–49, and had significantly greater body and brain weights at P52. We conclude that low-dose glibenclamide administered to the mother at the end of pregnancy protects pups subjected to IUI from post-natal events of elevated venous pressure and its consequences.
Author Tosun, Cigdem
Simard, J Marc
Gerzanich, Volodymyr
Koltz, Michael T
Kurland, David B
Gurakar, Melda
Schwartzbauer, Gary
Ijaz, Hina
Ivanova, Svetlana
Coksaygan, Turhan
AuthorAffiliation 1 Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA; E-Mails: cigdemtosun@gmail.com (C.T.); mtkoltz@gmail.com (M.T.K.); kurland.davidb@gmail.com (D.B.K.); hinaijaz92@gmail.com (H.I.); meldagurakar@hotmail.com (M.G.); gschwartzbauer@smail.umaryland.edu (G.S.); sveta0652@yahoo.com (S.I.); vgerzanich@smail.umaryland.edu (V.G.)
2 Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA; E-Mail: tcoksaygan@vetmed.umaryland.edu
3 Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
AuthorAffiliation_xml – name: 1 Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA; E-Mails: cigdemtosun@gmail.com (C.T.); mtkoltz@gmail.com (M.T.K.); kurland.davidb@gmail.com (D.B.K.); hinaijaz92@gmail.com (H.I.); meldagurakar@hotmail.com (M.G.); gschwartzbauer@smail.umaryland.edu (G.S.); sveta0652@yahoo.com (S.I.); vgerzanich@smail.umaryland.edu (V.G.)
– name: 2 Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA; E-Mail: tcoksaygan@vetmed.umaryland.edu
– name: 3 Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Author_xml – sequence: 1
  givenname: Cigdem
  surname: Tosun
  fullname: Tosun, Cigdem
  organization: Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
– sequence: 2
  givenname: Michael T
  surname: Koltz
  fullname: Koltz, Michael T
– sequence: 3
  givenname: David B
  surname: Kurland
  fullname: Kurland, David B
– sequence: 4
  givenname: Hina
  surname: Ijaz
  fullname: Ijaz, Hina
– sequence: 5
  givenname: Melda
  surname: Gurakar
  fullname: Gurakar, Melda
– sequence: 6
  givenname: Gary
  surname: Schwartzbauer
  fullname: Schwartzbauer, Gary
– sequence: 7
  givenname: Turhan
  surname: Coksaygan
  fullname: Coksaygan, Turhan
– sequence: 8
  givenname: Svetlana
  surname: Ivanova
  fullname: Ivanova, Svetlana
– sequence: 9
  givenname: Volodymyr
  surname: Gerzanich
  fullname: Gerzanich, Volodymyr
– sequence: 10
  givenname: J Marc
  surname: Simard
  fullname: Simard, J Marc
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23667741$$D View this record in MEDLINE/PubMed
BookMark eNpdkktP3DAQgC1EBZRy7q2K1EsvWxzb8eNSqUJ9ICH1AlesiT3eeJXEqZMg7b8n6VIE-OKR5_OnGXvek-M-9UjIx5J-5dzQyzpD7EcXOS0pK6sjcsaokhsuWHX8Ij4lF-O4o8vSlPKKnpBTxqVUSpRn5P62wWLIaUI3xQcsMIQlKlIotm2ssXctdNFjEfsCii55bNdcg13KuYFtdMXC4NBAmwaYmv2aHTJ2MM05TvsP5F2AdsSLp_2c3P38cXv1e3Pz59f11febjRNaTRtBuapYHTwH8BpNkMYorb13tJQhBKG1MmyFHOO-FjVXjkmnjPGiorrk5-T64PUJdnbIsYO8twmi_XeQ8tZCnqJr0XoI3HhmalZSAZUEL5lyzulQK8aCXlzfDq5hrjv0DvspQ_tK-jrTx8Zu04PlUiih2SL48iTI6e-M42S7ODpsW-gxzaMtK0EV1YKJBf38Bt2lOffLUy0U44pWkq_dXR4ol9M4ZgzPxZTUrqNg34zCcuPTyx6e-f8fzx8BDCizVQ
CitedBy_id crossref_primary_10_3389_fncel_2020_00112
crossref_primary_10_1089_neu_2018_6019
crossref_primary_10_1371_journal_pone_0136151
crossref_primary_10_1371_journal_pone_0171163
crossref_primary_10_3389_fphar_2023_1185533
crossref_primary_10_1007_s12028_013_9923_1
crossref_primary_10_1016_j_clnu_2020_10_005
crossref_primary_10_1038_sc_2013_99
crossref_primary_10_1007_s12035_021_02681_7
crossref_primary_10_1007_s12975_015_0432_8
crossref_primary_10_1007_s10787_022_01023_w
crossref_primary_10_1007_s12264_023_01118_6
crossref_primary_10_1097_CCM_0000000000001093
crossref_primary_10_3390_ph6101287
crossref_primary_10_1055_s_0040_1716710
crossref_primary_10_3390_ph15010040
crossref_primary_10_1016_j_bbadis_2018_01_013
crossref_primary_10_1586_14737175_2014_890891
crossref_primary_10_1089_neu_2016_4491
crossref_primary_10_1038_pr_2015_34
crossref_primary_10_3390_ijms16034973
crossref_primary_10_1039_C7RA03042H
crossref_primary_10_3389_fnins_2015_00040
crossref_primary_10_1080_14728222_2021_2010045
crossref_primary_10_1080_13543784_2019_1681967
crossref_primary_10_3390_ijms222111899
crossref_primary_10_1016_j_trsl_2020_10_003
crossref_primary_10_1161_JAHA_116_003465
Cites_doi 10.1016/j.expneurol.2012.04.003
10.1074/jbc.M003894200
10.1016/j.expneurol.2005.09.010
10.1097/00005072-198907000-00007
10.1177/0884217505276255
10.1080/00031305.1981.10479327
10.1542/peds.2007-0211
10.1016/j.neuron.2004.05.010
10.1345/aph.1K577
10.1038/jcbfm.2011.159
10.1002/ana.23680
10.1046/j.1563-258x.2002.01110.x
10.2217/WHE.09.55
10.1161/01.STR.22.3.390
10.1007/s00381-006-0050-6
10.1159/000243948
10.1161/01.HYP.0000053448.95913.3D
10.1097/00000542-200312000-00014
10.1038/nm1558
10.1111/j.1471-4159.2009.06060.x
10.1016/0165-3806(94)00168-Y
10.1007/s007020070004
10.1542/peds.2005-0191
10.1097/00006123-199711000-00015
10.1016/S0887-8994(03)00404-1
10.1542/peds.2010-0710
10.1016/j.brainres.2009.03.010
10.1007/978-3-7091-0693-8_10
10.1542/peds.109.3.434
10.3389/fphys.2012.00424
10.2337/diacare.28.8.1851
10.1177/08830738060210050201
10.1016/j.spen.2009.09.003
10.1038/clpt.2009.5
10.1007/s12975-012-0149-x
10.1136/adc.2009.174433
10.1038/jcbfm.2012.91
10.3171/2011.9.PEDS11174
10.1097/NEN.0b013e3181fbf6d6
10.1002/cne.1324
10.1007/s00431-007-0649-y
10.3109/15513819309048264
10.1038/jcbfm.2012.166
10.1111/j.1749-6632.2012.06705.x
10.1126/science.1151120
10.1542/peds.2007-3305
10.1126/science.1135801
10.1542/peds.2008-2816
10.1074/jbc.M112.428219
10.1002/jnr.21618
10.1111/j.1469-8749.1982.tb13625.x
10.1161/STROKEAHA.109.549212
10.1097/01.AOG.0000130838.02410.b7
10.1002/1098-2353(2000)13:6<422::AID-CA5>3.0.CO;2-F
10.1016/0046-8177(90)90256-5
10.1016/S1474-4422(08)70294-1
10.1016/j.braindev.2011.04.006
10.1001/archneur.55.3.297
10.1007/s001250050348
10.3171/jns.1982.56.3.0404
10.2165/00128072-200204110-00007
10.1002/ar.a.20104
10.1089/neu.2007.0274
10.1203/PDR.0b013e318186e5a9
10.1038/nm1390
10.1203/PDR.0b013e3181c1b176
10.1161/STROKEAHA.107.510883
10.1161/STROKEAHA.110.588400
10.1067/mob.2002.121624
10.1126/science.1140263
10.1126/science.7100929
10.1016/S0165-0173(01)00067-4
10.1177/08830738050200120301
10.1016/S0140-6736(08)61929-7
10.3109/14767058.2011.580402
10.1161/STROKEAHA.107.482216
10.1523/JNEUROSCI.3281-07.2007
10.1097/00006123-199705000-00021
10.1345/aph.1K045
10.1016/S0031-3955(16)34248-1
10.1016/j.expneurol.2012.02.010
10.1016/j.brainres.2010.07.106
10.1016/0165-0270(84)90007-4
10.1007/s11892-011-0249-0
10.3171/jns.1983.58.2.0204
ContentType Journal Article
Copyright Copyright MDPI AG 2013
2013 by the authors; licensee MDPI, Basel, Switzerland. 2013
Copyright_xml – notice: Copyright MDPI AG 2013
– notice: 2013 by the authors; licensee MDPI, Basel, Switzerland. 2013
DBID NPM
AAYXX
CITATION
3V.
7TK
7XB
8FE
8FH
8FK
8G5
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
GNUQQ
GUQSH
HCIFZ
LK8
M2O
M7P
MBDVC
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
DOA
DOI 10.3390/brainsci3010215
DatabaseName PubMed
CrossRef
ProQuest Central (Corporate)
Neurosciences Abstracts
ProQuest Central (purchase pre-March 2016)
ProQuest SciTech Collection
ProQuest Natural Science Collection
ProQuest Central (Alumni) (purchase pre-March 2016)
Research Library (Alumni Edition)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central Korea
ProQuest Central Student
Research Library Prep
SciTech Premium Collection
ProQuest Biological Science Collection
ProQuest research library
Biological Science Database
Research Library (Corporate)
Publicly Available Content (ProQuest)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle PubMed
CrossRef
Publicly Available Content Database
Research Library Prep
ProQuest Central Student
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest Central Essentials
ProQuest One Academic Eastern Edition
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
Research Library (Alumni Edition)
ProQuest Natural Science Collection
Biological Science Database
ProQuest SciTech Collection
Neurosciences Abstracts
ProQuest Central China
ProQuest Central
ProQuest One Academic UKI Edition
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest Research Library
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList CrossRef

PubMed
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
EISSN 2076-3425
EndPage 238
ExternalDocumentID oai_doaj_org_article_daf39d29b2104a56ad627ccc8fb722f8
3300316741
10_3390_brainsci3010215
23667741
Genre Journal Article
GrantInformation_xml – fundername: NINDS NIH HHS
  grantid: R01 NS061808
– fundername: NHLBI NIH HHS
  grantid: R01 HL082517
GroupedDBID 3V.
53G
5VS
8FE
8FH
8G5
AADQD
AAFWJ
ABDBF
ABUWG
ADBBV
ADRAZ
AFKRA
AFZYC
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
CCPQU
DWQXO
EBD
ESX
GNUQQ
GROUPED_DOAJ
GUQSH
HCIFZ
HYE
IPNFZ
KQ8
LK8
M2O
M48
M7P
MODMG
M~E
NPM
OK1
PGMZT
PIMPY
PQQKQ
PROAC
RIG
RPM
AAYXX
CITATION
7TK
7XB
8FK
MBDVC
PQEST
PQUKI
PRINS
Q9U
7X8
5PM
AFPKN
ID FETCH-LOGICAL-c487t-403752bfd3aad8e9f699788ddc016fff4887920375c23db4b37c26c799d450813
IEDL.DBID RPM
ISSN 2076-3425
IngestDate Tue Oct 22 15:15:20 EDT 2024
Tue Sep 17 20:52:31 EDT 2024
Sat Oct 05 05:16:50 EDT 2024
Thu Oct 10 17:16:03 EDT 2024
Fri Dec 06 02:16:32 EST 2024
Tue Oct 15 23:46:13 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords germinal matrix hemorrhage
intraventricular hemorrhage
sulfonylurea receptor 1
encephalopathy of prematurity
glibenclamide
choroid plexus hemorrhage
Language English
License https://creativecommons.org/licenses/by/3.0
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c487t-403752bfd3aad8e9f699788ddc016fff4887920375c23db4b37c26c799d450813
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647482/
PMID 23667741
PQID 1523705631
PQPubID 2032423
PageCount 24
ParticipantIDs doaj_primary_oai_doaj_org_article_daf39d29b2104a56ad627ccc8fb722f8
pubmedcentral_primary_oai_pubmedcentral_nih_gov_3647482
proquest_miscellaneous_1540708424
proquest_journals_1523705631
crossref_primary_10_3390_brainsci3010215
pubmed_primary_23667741
PublicationCentury 2000
PublicationDate 20130307
PublicationDateYYYYMMDD 2013-03-07
PublicationDate_xml – month: 3
  year: 2013
  text: 20130307
  day: 7
PublicationDecade 2010
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
– name: Basel
PublicationTitle Brain sciences
PublicationTitleAlternate Brain Sci
PublicationYear 2013
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
References 21631239 - J Matern Fetal Neonatal Med. 2012 Apr;25(4):379-84
2003309 - Stroke. 1991 Mar;22(3):390-5
19945652 - Semin Pediatr Neurol. 2009 Dec;16(4):179-90
18622055 - Pharmacol Rep. 2008 May-Jun;60(3):308-18
2210729 - Hum Pathol. 1990 Oct;21(10):1059-62
17556551 - Science. 2007 Jul 6;317(5834):94-9
6752852 - Pediatr Clin North Am. 1982 Oct;29(5):1077-1104
6471907 - J Neurosci Methods. 1984 May;11(1):47-60
19863468 - Womens Health (Lond). 2009 Nov;5(6):649-58
22994227 - Ann N Y Acad Sci. 2012 Sep;1268:95-107
6848677 - J Neurosurg. 1983 Feb;58(2):204-9
7095303 - Dev Med Child Neurol. 1982 Jun;24(3):332-7
18200449 - Eur J Pediatr. 2008 Oct;167(10):1209-12
12390047 - Paediatr Drugs. 2002;4(11):755-60
21107131 - J Neuropathol Exp Neurol. 2010 Dec;69(12):1177-90
18541618 - Pediatrics. 2008 Jul;122(1):e46-52
7057238 - J Neurosurg. 1982 Mar;56(3):404-10
7100929 - Science. 1982 Aug 27;217(4562):855-7
3064896 - Zhonghua Yi Xue Za Zhi (Taipei). 1988 Jul;42(1):47-52
15890835 - J Obstet Gynecol Neonatal Nurs. 2005 May-Jun;34(3):358-66
20530098 - Arch Dis Child Fetal Neonatal Ed. 2011 May;96(3):F169-77
23162470 - Front Physiol. 2012 Nov 09;3:424
19295505 - Clin Pharmacol Ther. 2009 Jun;85(6):607-14
17535842 - Ann Pharmacother. 2007 Jul;41(7):1174-80
16043722 - Diabetes Care. 2005 Aug;28(8):1851-5
22086197 - J Cereb Blood Flow Metab. 2012 Mar;32(3):525-36
22714048 - J Cereb Blood Flow Metab. 2012 Sep;32(9):1699-717
23280795 - Ann Neurol. 2012 Nov;72(5):799-806
22139557 - Curr Diab Rep. 2012 Feb;12(1):33-42
14639145 - Anesthesiology. 2003 Dec;99(6):1333-9
20616316 - Stroke. 2010 Aug;41(8):1766-73
22387180 - Exp Neurol. 2012 May;235(1):282-96
20692236 - Brain Res. 2010 Oct 14;1356:130-8
17401377 - Nat Med. 2007 Apr;13(4):477-85
12623943 - Hypertension. 2003 Mar;41(3):457-62
11516773 - Brain Res Brain Res Rev. 2001 Aug;36(1):60-90
11875138 - Pediatrics. 2002 Mar;109(3):434-40
11967518 - Am J Obstet Gynecol. 2002 Apr;186(4):843-9
9111655 - AJNR Am J Neuroradiol. 1997 Feb;18(2):219-29
7573535 - Am J Physiol. 1995 Sep;269(3 Pt 2):H916-22
15995055 - Pediatrics. 2005 Jul;116(1):221-5
16901440 - J Child Neurol. 2006 May;21(5):365-71
19661479 - Stroke. 2009 Oct;40(10):3369-77
9149257 - Neurosurgery. 1997 May;40(5):983-8; discussion 988-9
19081519 - Lancet Neurol. 2009 Jan;8(1):110-24
10825178 - J Biol Chem. 2000 Aug 11;275(32):24583-9
18349305 - Ann Pharmacother. 2008 Apr;42(4):483-90
16550187 - Nat Med. 2006 Apr;12(4):433-40
23255597 - J Biol Chem. 2013 Feb 1;288(5):3655-67
2732755 - J Neuropathol Exp Neurol. 1989 Jul;48(4):462-82
19816235 - Pediatr Res. 2010 Jan;67(1):1-8
18679166 - Pediatr Res. 2008 Dec;64(6):648-52
23149556 - J Cereb Blood Flow Metab. 2013 Mar;33(3):356-64
22707989 - Transl Stroke Res. 2012 Jun;3(2):286-95
8108297 - Pediatr Pathol. 1993 Nov-Dec;13(6):773-85
21725732 - Acta Neurochir Suppl. 2011;111:55-60
15182719 - Neuron. 2004 Jun 10;42(5):803-15
8353161 - Biol Neonate. 1993;63(5):316-26
19651588 - Pediatrics. 2009 Aug;124(2):717-28
19366943 - Can Fam Physician. 2009 Apr;55(4):371-3
7720213 - Brain Res Dev Brain Res. 1995 Jan 14;84(1):142-9
15291991 - Obstet Gynecol. 2004 Aug;104(2):225-31
16271716 - Exp Neurol. 2006 Jan;197(1):122-32
19101390 - Lancet. 2008 Dec 20;372(9656):2143-51
19476544 - J Neurochem. 2009 Jun;109(5):1285-99
21680121 - Brain Dev. 2012 Mar;34(3):201-5
11111893 - Clin Anat. 2000;13(6):422-8
6816037 - AJNR Am J Neuroradiol. 1982 Nov-Dec;3(6):619-22
17303747 - Science. 2007 Feb 16;315(5814):961-6
661382 - Mayo Clin Proc. 1978 Jul;53(7):437-41
15470665 - Anat Rec A Discov Mol Cell Evol Biol. 2005 Jan;282(1):8-12
14738951 - Pediatr Neurol. 2004 Jan;30(1):46-53
9361065 - Neurosurgery. 1997 Nov;41(5):1111-7; discussion 1117-8
11458993 - J Neural Transm (Vienna). 2000;107(12):1403-12
17978043 - J Neurosci. 2007 Oct 31;27(44):12012-24
22988544 - Stroke Res Treat. 2012;2012:460909
18845808 - Stroke. 2008 Dec;39(12 ):3378-88
11862688 - Wien Med Wochenschr. 2002;152(1-2):9-13
19306849 - Brain Res. 2009 May 13;1270:131-9
17673715 - Stroke. 2007 Sep;38(9):2526-30
20679313 - Pediatrics. 2010 Aug;126(2):342-51
18218862 - Science. 2008 Feb 29;319(5867):1260-4
7556974 - Diabetologia. 1995 Jul;38(7):753-6
22132923 - J Neurosurg Pediatr. 2011 Dec;8(6):628-39
11559897 - J Comp Neurol. 2001 Oct 1;438(4):411-22
22524990 - Exp Neurol. 2012 Jul;236(1):69-78
17711392 - J Neurotrauma. 2007 Aug;24(8):1308-20
16417840 - J Child Neurol. 2005 Dec;20(12):940-9
17908766 - Pediatrics. 2007 Oct;120(4):785-92
16636880 - Childs Nerv Syst. 2006 Sep;22(9):1086-90
3578185 - Am J Dis Child. 1987 Jun;141(6):617-21
9520002 - Arch Neurol. 1998 Mar;55(3):297-300
18214989 - J Neurosci Res. 2008 May 15;86(7):1482-500
Czlonkowska (ref_48) 2000; 107
Roze (ref_15) 2008; 122
Pellicer (ref_35) 2002; 109
Aly (ref_34) 2012; 34
Folkerth (ref_7) 2005; 20
Balasubramaniam (ref_65) 2006; 21
Melamed (ref_78) 2009; 5
Brown (ref_31) 1997; 18
Ballas (ref_84) 2012; 12
Doyle (ref_12) 2010; 126
Pikus (ref_14) 1997; 40
Koltz (ref_41) 2011; 8
Ortega (ref_62) 2012; 235
Sivan (ref_47) 1995; 38
Volpe (ref_4) 2005; 116
Aghajafari (ref_55) 2002; 186
Woo (ref_75) 2013; 288
Bassan (ref_9) 2007; 120
Ballabh (ref_20) 2010; 67
Rinaman (ref_93) 2001; 438
Feig (ref_82) 2007; 41
Juliet (ref_17) 2009; 109
Xu (ref_28) 2008; 86
Scott (ref_26) 2005; 282
Zhou (ref_57) 2009; 1270
Alexander (ref_86) 2003; 41
Volpe (ref_5) 2009; 8
Wei (ref_24) 2000; 13
Shen (ref_39) 1988; 42
Cheng (ref_81) 2011; 25
Ortega (ref_61) 2013; 33
Braun (ref_27) 2007; 27
Xu (ref_76) 2000; 275
Kunte (ref_42) 2012; 72
Simard (ref_43) 2012; 32
Kunte (ref_45) 2007; 38
Conner (ref_70) 1983; 58
Simard (ref_77) 2006; 12
Ment (ref_22) 1991; 22
Volpe (ref_8) 1998; 55
Morris (ref_91) 1984; 11
Donat (ref_36) 1978; 53
Reeder (ref_38) 1982; 3
Claas (ref_11) 2011; 96
Patel (ref_92) 2010; 69
Kadri (ref_33) 2006; 22
Murphy (ref_56) 2008; 372
Oosterlaan (ref_10) 2009; 124
Feig (ref_63) 2005; 28
(ref_90) 2001; 36
Lekic (ref_67) 2011; 111
Anstrom (ref_25) 2004; 30
Conover (ref_94) 1981; 35
Mito (ref_18) 1993; 13
Ballabh (ref_29) 2007; 13
Levy (ref_13) 1997; 41
Nakahata (ref_59) 2003; 99
Moretti (ref_79) 2008; 42
Simard (ref_74) 2012; 1268
Vinukonda (ref_54) 2010; 41
Kinney (ref_6) 2009; 16
Simard (ref_44) 2008; 64
Woo (ref_46) 2012; 32
Leutgeb (ref_50) 2007; 315
Marciniak (ref_80) 2008; 60
Glatstein (ref_64) 2009; 55
Nakamura (ref_32) 1990; 21
Liu (ref_53) 2008; 167
Ment (ref_23) 1995; 84
Gradnitzer (ref_40) 2002; 152
Hebert (ref_85) 2009; 85
Baburamani (ref_30) 2012; 3
McHugh (ref_51) 2007; 317
Lee (ref_49) 2004; 42
Lekic (ref_68) 2012; 236
Coulter (ref_72) 1993; 63
Merlob (ref_83) 2002; 4
Reid (ref_60) 1995; 269
Wali (ref_58) 2012; 2012
Simard (ref_87) 2012; 3
Feeney (ref_88) 1982; 217
Balasubramaniam (ref_16) 2006; 197
Lacey (ref_37) 1982; 24
Sotrel (ref_21) 1989; 48
Wagner (ref_89) 2007; 24
Vergani (ref_3) 2004; 104
Bloch (ref_19) 2005; 34
Tarby (ref_1) 1982; 29
Chua (ref_71) 2009; 40
Lorenzo (ref_69) 1982; 56
Georgiadis (ref_73) 2008; 39
Armstrong (ref_2) 1987; 141
Nakashiba (ref_52) 2008; 319
Alles (ref_66) 2010; 1356
References_xml – volume: 236
  start-page: 69
  year: 2012
  ident: ref_68
  article-title: Rodent neonatal germinal matrix hemorrhage mimics the human brain injury, neurological consequences, and post-hemorrhagic hydrocephalus
  publication-title: Exp. Neurol.
  doi: 10.1016/j.expneurol.2012.04.003
  contributor:
    fullname: Lekic
– volume: 275
  start-page: 24583
  year: 2000
  ident: ref_76
  article-title: Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium. Implications for the mechanisms of aortic aneurysm and heart failure
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M003894200
  contributor:
    fullname: Xu
– volume: 197
  start-page: 122
  year: 2006
  ident: ref_16
  article-title: Persistent motor deficit following infusion of autologous blood into the periventricular region of neonatal rats
  publication-title: Exp. Neurol.
  doi: 10.1016/j.expneurol.2005.09.010
  contributor:
    fullname: Balasubramaniam
– volume: 48
  start-page: 462
  year: 1989
  ident: ref_21
  article-title: Ultrastructure of blood vessels in the ganglionic eminence of premature rabbits with spontaneous germinal matrix hemorrhages
  publication-title: J. Neuropathol. Exp. Neurol.
  doi: 10.1097/00005072-198907000-00007
  contributor:
    fullname: Sotrel
– volume: 34
  start-page: 358
  year: 2005
  ident: ref_19
  article-title: Antenatal events causing neonatal brain injury in premature infants
  publication-title: J. Obstet. Gynecol. Neonatal Nurs.
  doi: 10.1177/0884217505276255
  contributor:
    fullname: Bloch
– volume: 35
  start-page: 124
  year: 1981
  ident: ref_94
  article-title: Rank Transformations as a bridge between parametric and nonparametric statistics
  publication-title: Am. Stat.
  doi: 10.1080/00031305.1981.10479327
  contributor:
    fullname: Conover
– volume: 269
  start-page: H916
  year: 1995
  ident: ref_60
  article-title: Effect of L-NMMA, cromakalim, and glibenclamide on cerebral blood flow in hypercapnia and hypoxia
  publication-title: Am. J. Physiol.
  contributor:
    fullname: Reid
– volume: 120
  start-page: 785
  year: 2007
  ident: ref_9
  article-title: Neurodevelopmental outcome in survivors of periventricular hemorrhagic infarction
  publication-title: Pediatrics
  doi: 10.1542/peds.2007-0211
  contributor:
    fullname: Bassan
– volume: 42
  start-page: 803
  year: 2004
  ident: ref_49
  article-title: A double dissociation between hippocampal subfields: Differential time course of CA3 and CA1 place cells for processing changed environments
  publication-title: Neuron
  doi: 10.1016/j.neuron.2004.05.010
  contributor:
    fullname: Lee
– volume: 42
  start-page: 483
  year: 2008
  ident: ref_79
  article-title: Safety of glyburide for gestational diabetes: A meta-analysis of pregnancy outcomes
  publication-title: Ann. Pharmacother.
  doi: 10.1345/aph.1K577
  contributor:
    fullname: Moretti
– volume: 32
  start-page: 525
  year: 2012
  ident: ref_46
  article-title: Sequential activation of hypoxia-inducible factor 1 and specificity protein 1 is required for hypoxia-induced transcriptional stimulation of Abcc8
  publication-title: J. Cereb. Blood Flow Metab.
  doi: 10.1038/jcbfm.2011.159
  contributor:
    fullname: Woo
– volume: 72
  start-page: 799
  year: 2012
  ident: ref_42
  article-title: Hemorrhagic transformation of ischemic stroke in diabetics on sulfonylureas
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.23680
  contributor:
    fullname: Kunte
– volume: 152
  start-page: 9
  year: 2002
  ident: ref_40
  article-title: Cerebral hemorrhage in term newborn infants—An analysis of 10 years (1989–1999)
  publication-title: Wien. Med. Wochenschr.
  doi: 10.1046/j.1563-258x.2002.01110.x
  contributor:
    fullname: Gradnitzer
– volume: 5
  start-page: 649
  year: 2009
  ident: ref_78
  article-title: Can pregnant diabetics be treated with glyburide?
  publication-title: Womens Health (Lond. Engl.)
  doi: 10.2217/WHE.09.55
  contributor:
    fullname: Melamed
– volume: 22
  start-page: 390
  year: 1991
  ident: ref_22
  article-title: Beagle pup germinal matrix maturation studies
  publication-title: Stroke
  doi: 10.1161/01.STR.22.3.390
  contributor:
    fullname: Ment
– volume: 22
  start-page: 1086
  year: 2006
  ident: ref_33
  article-title: The incidence, timing, and predisposing factors of germinal matrix and intraventricular hemorrhage (GMH/IVH) in preterm neonates
  publication-title: Childs Nerv. Syst.
  doi: 10.1007/s00381-006-0050-6
  contributor:
    fullname: Kadri
– volume: 63
  start-page: 316
  year: 1993
  ident: ref_72
  article-title: Falling intracranial pressure: an important element in the genesis of intracranial hemorrhage in the beagle puppy
  publication-title: Biol. Neonate
  doi: 10.1159/000243948
  contributor:
    fullname: Coulter
– volume: 60
  start-page: 308
  year: 2008
  ident: ref_80
  article-title: Glyburide for the treatment of gestational diabetes mellitus
  publication-title: Pharmacol. Rep.
  contributor:
    fullname: Marciniak
– volume: 41
  start-page: 457
  year: 2003
  ident: ref_86
  article-title: Placental insufficiency leads to development of hypertension in growth-restricted offspring
  publication-title: Hypertension
  doi: 10.1161/01.HYP.0000053448.95913.3D
  contributor:
    fullname: Alexander
– volume: 99
  start-page: 1333
  year: 2003
  ident: ref_59
  article-title: Mild hypercapnia induces vasodilation via adenosine triphosphate-sensitive K+ channels in parenchymal microvessels of the rat cerebral cortex
  publication-title: Anesthesiology
  doi: 10.1097/00000542-200312000-00014
  contributor:
    fullname: Nakahata
– volume: 13
  start-page: 477
  year: 2007
  ident: ref_29
  article-title: Angiogenic inhibition reduces germinal matrix hemorrhage
  publication-title: Nat. Med.
  doi: 10.1038/nm1558
  contributor:
    fullname: Ballabh
– volume: 109
  start-page: 1285
  year: 2009
  ident: ref_17
  article-title: Toxic effect of blood components on perinatal rat subventricular zone cells and oligodendrocyte precursor cell proliferation, differentiation and migration in culture
  publication-title: J. Neurochem.
  doi: 10.1111/j.1471-4159.2009.06060.x
  contributor:
    fullname: Juliet
– volume: 84
  start-page: 142
  year: 1995
  ident: ref_23
  article-title: Germinal matrix microvascular maturation correlates inversely with the risk period for neonatal intraventricular hemorrhage
  publication-title: Brain Res. Dev. Brain Res.
  doi: 10.1016/0165-3806(94)00168-Y
  contributor:
    fullname: Ment
– volume: 107
  start-page: 1403
  year: 2000
  ident: ref_48
  article-title: The effects of physostigmine and cholinergic receptor ligands on novelty-induced neophobia
  publication-title: J. Neural Transm.
  doi: 10.1007/s007020070004
  contributor:
    fullname: Czlonkowska
– volume: 116
  start-page: 221
  year: 2005
  ident: ref_4
  article-title: Encephalopathy of prematurity includes neuronal abnormalities
  publication-title: Pediatrics
  doi: 10.1542/peds.2005-0191
  contributor:
    fullname: Volpe
– volume: 41
  start-page: 1111
  year: 1997
  ident: ref_13
  article-title: Outcome for preterm infants with germinal matrix hemorrhage and progressive hydrocephalus
  publication-title: Neurosurgery
  doi: 10.1097/00006123-199711000-00015
  contributor:
    fullname: Levy
– volume: 30
  start-page: 46
  year: 2004
  ident: ref_25
  article-title: Subependymal veins in premature neonates: implications for hemorrhage
  publication-title: Pediatr. Neurol.
  doi: 10.1016/S0887-8994(03)00404-1
  contributor:
    fullname: Anstrom
– volume: 126
  start-page: 342
  year: 2010
  ident: ref_12
  article-title: Adult outcome of extremely preterm infants
  publication-title: Pediatrics
  doi: 10.1542/peds.2010-0710
  contributor:
    fullname: Doyle
– volume: 1270
  start-page: 131
  year: 2009
  ident: ref_57
  article-title: Glibenclamide improves neurological function in neonatal hypoxia-ischemia in rats
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2009.03.010
  contributor:
    fullname: Zhou
– volume: 111
  start-page: 55
  year: 2011
  ident: ref_67
  article-title: A novel preclinical model of germinal matrix hemorrhage using neonatal rats
  publication-title: Acta Neurochir. Suppl.
  doi: 10.1007/978-3-7091-0693-8_10
  contributor:
    fullname: Lekic
– volume: 109
  start-page: 434
  year: 2002
  ident: ref_35
  article-title: Noninvasive continuous monitoring of the effects of head position on brain hemodynamics in ventilated infants
  publication-title: Pediatrics
  doi: 10.1542/peds.109.3.434
  contributor:
    fullname: Pellicer
– volume: 3
  start-page: 424
  year: 2012
  ident: ref_30
  article-title: Vulnerability of the developing brain to hypoxic-ischemic damage: Contribution of the cerebral vasculature to injury and repair?
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2012.00424
  contributor:
    fullname: Baburamani
– volume: 28
  start-page: 1851
  year: 2005
  ident: ref_63
  article-title: Transfer of glyburide and glipizide into breast milk
  publication-title: Diabetes Care
  doi: 10.2337/diacare.28.8.1851
  contributor:
    fullname: Feig
– volume: 21
  start-page: 365
  year: 2006
  ident: ref_65
  article-title: Animal models of germinal matrix hemorrhage
  publication-title: J. Child. Neurol.
  doi: 10.1177/08830738060210050201
  contributor:
    fullname: Balasubramaniam
– volume: 3
  start-page: 619
  year: 1982
  ident: ref_38
  article-title: Choroid plexus hemorrhage in premature neonates: Recognition by sonography
  publication-title: AJNR Am. J. Neuroradiol.
  contributor:
    fullname: Reeder
– volume: 16
  start-page: 179
  year: 2009
  ident: ref_6
  article-title: The encephalopathy of prematurity: One pediatric neuropathologist’s perspective
  publication-title: Semin. Pediatr. Neurol.
  doi: 10.1016/j.spen.2009.09.003
  contributor:
    fullname: Kinney
– volume: 85
  start-page: 607
  year: 2009
  ident: ref_85
  article-title: Are we optimizing gestational diabetes treatment with glyburide? The pharmacologic basis for better clinical practice
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1038/clpt.2009.5
  contributor:
    fullname: Hebert
– volume: 3
  start-page: 286
  year: 2012
  ident: ref_87
  article-title: Glibenclamide-10-h treatment window in a clinically relevant model of stroke
  publication-title: Transl. Stroke Res.
  doi: 10.1007/s12975-012-0149-x
  contributor:
    fullname: Simard
– volume: 96
  start-page: 169
  year: 2011
  ident: ref_11
  article-title: Two-year neurodevelopmental outcome of preterm born children ≤750 g at birth
  publication-title: Arch. Dis. Child. Fetal Neonatal Ed.
  doi: 10.1136/adc.2009.174433
  contributor:
    fullname: Claas
– volume: 32
  start-page: 1699
  year: 2012
  ident: ref_43
  article-title: Sulfonylurea receptor 1 in central nervous system injury: A focused review
  publication-title: J. Cereb. Blood Flow Metab.
  doi: 10.1038/jcbfm.2012.91
  contributor:
    fullname: Simard
– volume: 8
  start-page: 628
  year: 2011
  ident: ref_41
  article-title: Tandem insults of prenatal ischemia plus postnatal raised intrathoracic pressure in a novel rat model of encephalopathy of prematurity
  publication-title: J. Neurosurg. Pediatr.
  doi: 10.3171/2011.9.PEDS11174
  contributor:
    fullname: Koltz
– volume: 69
  start-page: 1177
  year: 2010
  ident: ref_92
  article-title: Glibenclamide reduces hippocampal injury and preserves rapid spatial learning in a model of traumatic brain injury
  publication-title: J. Neuropathol. Exp. Neurol.
  doi: 10.1097/NEN.0b013e3181fbf6d6
  contributor:
    fullname: Patel
– volume: 438
  start-page: 411
  year: 2001
  ident: ref_93
  article-title: Postnatal development of catecholamine inputs to the paraventricular nucleus of the hypothalamus in rats
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.1324
  contributor:
    fullname: Rinaman
– volume: 167
  start-page: 1209
  year: 2008
  ident: ref_53
  article-title: The role of antenatal corticosteroids for improving the maturation of choroid plexus capillaries in fetal mice
  publication-title: Eur J. Pediatr.
  doi: 10.1007/s00431-007-0649-y
  contributor:
    fullname: Liu
– volume: 13
  start-page: 773
  year: 1993
  ident: ref_18
  article-title: A neuropathologic analysis of neonatal deaths occurring in a single neonatal unit over a 20-year period
  publication-title: Pediatr. Pathol.
  doi: 10.3109/15513819309048264
  contributor:
    fullname: Mito
– volume: 33
  start-page: 356
  year: 2013
  ident: ref_61
  article-title: Glibenclamide enhances neurogenesis and improves long-term functional recovery after transient focal cerebral ischemia
  publication-title: J. Cereb. Blood Flow Metab.
  doi: 10.1038/jcbfm.2012.166
  contributor:
    fullname: Ortega
– volume: 1268
  start-page: 95
  year: 2012
  ident: ref_74
  article-title: Does inhibiting Sur1 complement rt-PA in cerebral ischemia?
  publication-title: Ann. N. Y. Acad. Sci.
  doi: 10.1111/j.1749-6632.2012.06705.x
  contributor:
    fullname: Simard
– volume: 319
  start-page: 1260
  year: 2008
  ident: ref_52
  article-title: Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning
  publication-title: Science
  doi: 10.1126/science.1151120
  contributor:
    fullname: Nakashiba
– volume: 122
  start-page: e46
  year: 2008
  ident: ref_15
  article-title: Risk factors for adverse outcome in preterm infants with periventricular hemorrhagic infarction
  publication-title: Pediatrics
  doi: 10.1542/peds.2007-3305
  contributor:
    fullname: Roze
– volume: 315
  start-page: 961
  year: 2007
  ident: ref_50
  article-title: Pattern separation in the dentate gyrus and CA3 of the hippocampus
  publication-title: Science
  doi: 10.1126/science.1135801
  contributor:
    fullname: Leutgeb
– volume: 124
  start-page: 717
  year: 2009
  ident: ref_10
  article-title: Meta-analysis of neurobehavioral outcomes in very preterm and/or very low birth weight children
  publication-title: Pediatrics
  doi: 10.1542/peds.2008-2816
  contributor:
    fullname: Oosterlaan
– volume: 288
  start-page: 3655
  year: 2013
  ident: ref_75
  article-title: The Sulfonylurea receptor 1 (Sur1)—Transient receptor potential melastatin 4 (Trpm4) channel
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112.428219
  contributor:
    fullname: Woo
– volume: 86
  start-page: 1482
  year: 2008
  ident: ref_28
  article-title: Maturational changes in laminin, fibronectin, collagen IV, and perlecan in germinal matrix, cortex, and white matter and effect of betamethasone
  publication-title: J. Neurosci. Res.
  doi: 10.1002/jnr.21618
  contributor:
    fullname: Xu
– volume: 24
  start-page: 332
  year: 1982
  ident: ref_37
  article-title: Intraventricular hemorrhage in full-term neonates
  publication-title: Dev. Med. Child Neurol.
  doi: 10.1111/j.1469-8749.1982.tb13625.x
  contributor:
    fullname: Lacey
– volume: 40
  start-page: 3369
  year: 2009
  ident: ref_71
  article-title: Consequences of intraventricular hemorrhage in a rabbit pup model
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.109.549212
  contributor:
    fullname: Chua
– volume: 104
  start-page: 225
  year: 2004
  ident: ref_3
  article-title: Intraventricular hemorrhage and periventricular leukomalacia in preterm infants
  publication-title: Obstet. Gynecol.
  doi: 10.1097/01.AOG.0000130838.02410.b7
  contributor:
    fullname: Vergani
– volume: 13
  start-page: 422
  year: 2000
  ident: ref_24
  article-title: Relationship between extracellular matrix both in choroid plexus and the wall of lateral ventricles and intraventricular hemorrhage in preterm neonates
  publication-title: Clin. Anat.
  doi: 10.1002/1098-2353(2000)13:6<422::AID-CA5>3.0.CO;2-F
  contributor:
    fullname: Wei
– volume: 21
  start-page: 1059
  year: 1990
  ident: ref_32
  article-title: Germinal matrix hemorrhage of venous origin in preterm neonates
  publication-title: Hum. Pathol.
  doi: 10.1016/0046-8177(90)90256-5
  contributor:
    fullname: Nakamura
– volume: 8
  start-page: 110
  year: 2009
  ident: ref_5
  article-title: Brain injury in premature infants: A complex amalgam of destructive and developmental disturbances
  publication-title: Lancet Neurol.
  doi: 10.1016/S1474-4422(08)70294-1
  contributor:
    fullname: Volpe
– volume: 34
  start-page: 201
  year: 2012
  ident: ref_34
  article-title: Is mechanical ventilation associated with intraventricular hemorrhage in preterm infants?
  publication-title: Brain Dev.
  doi: 10.1016/j.braindev.2011.04.006
  contributor:
    fullname: Aly
– volume: 55
  start-page: 297
  year: 1998
  ident: ref_8
  article-title: Neurologic outcome of prematurity
  publication-title: Arch. Neurol.
  doi: 10.1001/archneur.55.3.297
  contributor:
    fullname: Volpe
– volume: 38
  start-page: 753
  year: 1995
  ident: ref_47
  article-title: Glyburide crosses the placenta in vivo in pregnant rats
  publication-title: Diabetologia
  doi: 10.1007/s001250050348
  contributor:
    fullname: Sivan
– volume: 56
  start-page: 404
  year: 1982
  ident: ref_69
  article-title: Spontaneous germinal matrix and intraventricular hemorrhage in prematurely born rabbits
  publication-title: J. Neurosurg.
  doi: 10.3171/jns.1982.56.3.0404
  contributor:
    fullname: Lorenzo
– volume: 4
  start-page: 755
  year: 2002
  ident: ref_83
  article-title: Oral antihyperglycemic agents during pregnancy and lactation: A review
  publication-title: Paediatr. Drugs
  doi: 10.2165/00128072-200204110-00007
  contributor:
    fullname: Merlob
– volume: 282
  start-page: 8
  year: 2005
  ident: ref_26
  article-title: Fine structural correlates of the choroid plexus of the lateral cerebral ventricle of the human fetal brain
  publication-title: Anat. Rec. A Discov. Mol. Cell. Evol. Biol.
  doi: 10.1002/ar.a.20104
  contributor:
    fullname: Scott
– volume: 24
  start-page: 1308
  year: 2007
  ident: ref_89
  article-title: Deficits in novelty exploration after controlled cortical impact
  publication-title: J. Neurotrauma
  doi: 10.1089/neu.2007.0274
  contributor:
    fullname: Wagner
– volume: 64
  start-page: 648
  year: 2008
  ident: ref_44
  article-title: Sulfonylurea receptor 1 in the germinal matrix of premature infants
  publication-title: Pediatr. Res.
  doi: 10.1203/PDR.0b013e318186e5a9
  contributor:
    fullname: Simard
– volume: 12
  start-page: 433
  year: 2006
  ident: ref_77
  article-title: Newly expressed SUR1-regulated NC(Ca-ATP) channel mediates cerebral edema after ischemic stroke
  publication-title: Nat. Med.
  doi: 10.1038/nm1390
  contributor:
    fullname: Simard
– volume: 67
  start-page: 1
  year: 2010
  ident: ref_20
  article-title: Intraventricular hemorrhage in premature infants: Mechanism of disease
  publication-title: Pediatr. Res.
  doi: 10.1203/PDR.0b013e3181c1b176
  contributor:
    fullname: Ballabh
– volume: 39
  start-page: 3378
  year: 2008
  ident: ref_73
  article-title: Characterization of acute brain injuries and neurobehavioral profiles in a rabbit model of germinal matrix hemorrhage
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.107.510883
  contributor:
    fullname: Georgiadis
– volume: 41
  start-page: 1766
  year: 2010
  ident: ref_54
  article-title: Effect of prenatal glucocorticoids on cerebral vasculature of the developing brain
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.110.588400
  contributor:
    fullname: Vinukonda
– volume: 186
  start-page: 843
  year: 2002
  ident: ref_55
  article-title: Repeated doses of antenatal corticosteroids in animals: A systematic review
  publication-title: Am. J. Obstet. Gynecol.
  doi: 10.1067/mob.2002.121624
  contributor:
    fullname: Aghajafari
– volume: 55
  start-page: 371
  year: 2009
  ident: ref_64
  article-title: Use of hypoglycemic drugs during lactation
  publication-title: Can. Fam. Physician
  contributor:
    fullname: Glatstein
– volume: 18
  start-page: 219
  year: 1997
  ident: ref_31
  article-title: Human germinal matrix: Venous origin of hemorrhage and vascular characteristics
  publication-title: AJNR Am. J. Neuroradiol.
  contributor:
    fullname: Brown
– volume: 317
  start-page: 94
  year: 2007
  ident: ref_51
  article-title: Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network
  publication-title: Science
  doi: 10.1126/science.1140263
  contributor:
    fullname: McHugh
– volume: 217
  start-page: 855
  year: 1982
  ident: ref_88
  article-title: Amphetamine, haloperidol, and experience interact to affect rate of recovery after motor cortex injury
  publication-title: Science
  doi: 10.1126/science.7100929
  contributor:
    fullname: Feeney
– volume: 2012
  start-page: 460909
  year: 2012
  ident: ref_58
  article-title: Glibenclamide administration attenuates infarct volume, hemispheric swelling, and functional impairments following permanent focal cerebral ischemia in rats
  publication-title: Stroke Res. Treat.
  contributor:
    fullname: Wali
– volume: 36
  start-page: 60
  year: 2001
  ident: ref_90
  article-title: Applications of the Morris water maze in the study of learning and memory
  publication-title: Brain Res. Brain Res. Rev.
  doi: 10.1016/S0165-0173(01)00067-4
– volume: 53
  start-page: 437
  year: 1978
  ident: ref_36
  article-title: Intraventricular hemorrhages in full-term and premature infants
  publication-title: Mayo. Clin. Proc.
  contributor:
    fullname: Donat
– volume: 20
  start-page: 940
  year: 2005
  ident: ref_7
  article-title: Neuropathologic substrate of cerebral palsy
  publication-title: J. Child Neurol.
  doi: 10.1177/08830738050200120301
  contributor:
    fullname: Folkerth
– volume: 42
  start-page: 47
  year: 1988
  ident: ref_39
  article-title: Choroid plexus hemorrhage: Clinical and sonografic findings of nine cases
  publication-title: Zhonghua Yi Xue Za Zhi (Taipei)
  contributor:
    fullname: Shen
– volume: 372
  start-page: 2143
  year: 2008
  ident: ref_56
  article-title: Multiple courses of antenatal corticosteroids for preterm birth (MACS): A randomised controlled trial
  publication-title: Lancet
  doi: 10.1016/S0140-6736(08)61929-7
  contributor:
    fullname: Murphy
– volume: 25
  start-page: 379
  year: 2011
  ident: ref_81
  article-title: Treatment of gestational diabetes mellitus: Glyburide compared to subcutaneous insulin therapy and associated perinatal outcomes
  publication-title: J. Matern. Fetal Neonatal Med.
  doi: 10.3109/14767058.2011.580402
  contributor:
    fullname: Cheng
– volume: 38
  start-page: 2526
  year: 2007
  ident: ref_45
  article-title: Sulfonylureas improve outcome in patients with type 2 diabetes and acute ischemic stroke
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.107.482216
  contributor:
    fullname: Kunte
– volume: 141
  start-page: 617
  year: 1987
  ident: ref_2
  article-title: Neuropathologic findings in short-term survivors of intraventricular hemorrhage
  publication-title: Am. J. Dis. Child.
  contributor:
    fullname: Armstrong
– volume: 27
  start-page: 12012
  year: 2007
  ident: ref_27
  article-title: Paucity of pericytes in germinal matrix vasculature of premature infants
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.3281-07.2007
  contributor:
    fullname: Braun
– volume: 40
  start-page: 983
  year: 1997
  ident: ref_14
  article-title: Outcome, cost analysis, and long-term follow-up in preterm infants with massive grade IV germinal matrix hemorrhage and progressive hydrocephalus
  publication-title: Neurosurgery
  doi: 10.1097/00006123-199705000-00021
  contributor:
    fullname: Pikus
– volume: 41
  start-page: 1174
  year: 2007
  ident: ref_82
  article-title: Oral antidiabetic agents in pregnancy and lactation: A paradigm shift?
  publication-title: Ann. Pharmacother.
  doi: 10.1345/aph.1K045
  contributor:
    fullname: Feig
– volume: 29
  start-page: 1077
  year: 1982
  ident: ref_1
  article-title: Intraventricular hemorrhage in the premature infant
  publication-title: Pediatr. Clin. North Am.
  doi: 10.1016/S0031-3955(16)34248-1
  contributor:
    fullname: Tarby
– volume: 235
  start-page: 282
  year: 2012
  ident: ref_62
  article-title: ATP-dependent potassium channel blockade strengthens microglial neuroprotection after hypoxia-ischemia in rats
  publication-title: Exp. Neurol.
  doi: 10.1016/j.expneurol.2012.02.010
  contributor:
    fullname: Ortega
– volume: 1356
  start-page: 130
  year: 2010
  ident: ref_66
  article-title: A novel preclinical rodent model of collagenase-induced germinal matrix/intraventricular hemorrhage
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2010.07.106
  contributor:
    fullname: Alles
– volume: 11
  start-page: 47
  year: 1984
  ident: ref_91
  article-title: Developments of a water-maze procedure for studying spatial learning in the rat
  publication-title: J. Neurosci. Methods
  doi: 10.1016/0165-0270(84)90007-4
  contributor:
    fullname: Morris
– volume: 12
  start-page: 33
  year: 2012
  ident: ref_84
  article-title: Management of diabetes in pregnancy
  publication-title: Curr. Diab. Rep.
  doi: 10.1007/s11892-011-0249-0
  contributor:
    fullname: Ballas
– volume: 58
  start-page: 204
  year: 1983
  ident: ref_70
  article-title: The role of intracranial hypotension in neonatal intraventricular hemorrhage
  publication-title: J. Neurosurg.
  doi: 10.3171/jns.1983.58.2.0204
  contributor:
    fullname: Conner
SSID ssj0000800350
Score 2.0684311
Snippet We studied a model of hemorrhagic encephalopathy of prematurity (EP) that closely recapitulates findings in humans with hemorrhagic EP. This model involves...
SourceID doaj
pubmedcentral
proquest
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage 215
SubjectTerms choroid plexus hemorrhage
Encephalitis
encephalopathy of prematurity
germinal matrix hemorrhage
glibenclamide
Hemorrhage
intraventricular hemorrhage
Ischemia
Neurology
sulfonylurea receptor 1
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3PSxwxFA7iqRfRqnWsLRFEvAzOJpnJ5GiLdilUPCh46vDyi91iZ8t2Pfjf971kXHal4EXY0yYL2ZeX5PtmXr6PsROPaQQWoDTRhVLVbSitA1cGhccTBD-KLV0U_nHdjO_U9_v6fsXqi2rCsjxwDty5hyiNF8YiN1FQN-AboZ1zbbRaiJiv-VZihUz9GnCQTPasAol6KTEzs66PRI5_bsl9AU8YmYyt67UjKSn3_w9uvqyaXDmGrrbZ1oAf-UUe9w7bCP17tnvRI3f-_cRPearoTI_Kd9lPzAF-k4UYcFPjWamYzyL_RlUlvcNsmPrApz0HTqZoD9Q2ptrb-QRwS-SXdKdxAg8zMi5-otabOYm8Jsu7PXZ3dXn7dVwOfgqlQ1qyQKoodS1s9BLAt8HExiCHbL13iPtijLiWtRHUyQnprbJSO9E4bYxXiONGcp9t9rM-HDCuna5NBQBSRDWqgnWmabUKtfUYcF0V7Ow5pN2fLJvRId2g6Hcvol-wLxTyZTfSu05fYBZ0QxZ0r2VBwY6eJ6wbFuHfDqGJ1Ajw5Khgx8tmXD70TgT6MHukPshoq1YJVbAPeX6XIxGyaRAd46_12syvDXW9pZ9OkkQ3qfKrVhy-xX_7yN6J5MGBH33ENhfzx_AJkdDCfk5J_w_7mQiq
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3Na9RAFH_o9uJF1PoRrTKCiJfQZGaSmTlJK1sXwbKIhZ4M8-kutEndbg_9730vya5uESGnzASGed8zL78fwLuAamSdtblJPuay0jF33vo8SgxPNoYyafpR-OtpPTuTX86r8_HA7Xpsq9z4xN5Rh87TGfkhxhmhMFqL8uPVr5xYo-h2daTQuA97vBRaT2DveHo6_7Y9ZaF8SFTFgOkjsL4_dMS8gNFF9KTW1U446lH7_5Vq3u2Y_CsEnTyCh2PuyI4GYT-Ge7F9AvtHLdbNl7fsPeu7Oftj8n34gfJn8wGEAR0aG1CKWZfYZ-ooaT1qwjJEtmyZZUSIdkFjM-q7XS0sukM2pf8ZF_aiI9LiWxqdrwjgtae7ewpnJ9Pvn2b5yKWQeyxJ1lgmClVxl4KwNuhoUm2wftQheMz5Ukpox8pwmuS5CE46oTyvvTImSMzhSvEMJm3XxhfAlFeVKay1gidZFtF5U2slY-UCL5QqMviw2dLmaoDMaLDUoN1v7ux-Bse05dtphHXdv-hWP5vRdJpgkzCBG4fVqbRVbUPNlfdeJ6c4TzqDg43AmtEAr5s_6pLB2-0wmg7dh9g2djc0B6vZQksuM3g-yHe7Ei7qGjNj_FrtSH5nqbsj7XLRw3MTIr_U_OX_l_UKHvCeWQMfdQCT9eomvsb8Zu3ejEr8G8Rk_sg
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9QwELWgXLggoHykLchICHEJJLYT2weECmpZIRX1wEo9EfmTXbRNIGyl7r9nxskubLUnpJxiR4o848x7yeQ9Ql56SCNjjcl1dCEXlQq5dcblQUB5MsGXUeGPwmdf6slUfL6oLv7aAY0L-HsntUM_qWm_eHP9a_UeNvw7ZJxA2d9aNFOAgsGTT3V1m9xhUBaxv-tsxPo_RmjEq2KQ99l1HeoC87oGPFRuFamk5b8LgN7so_ynMJ3eJ_dGREmPhxR4QG6F9iHZP26BTV-u6CuaejzTy_N98g2ygp4P0gzwmKODdjHtIv2EfSatg_yY-0DnLTUUbdIWODbBbtx-ZuAhSU_wL8eZWXRoZbzC0fMeZV-TCd4jMj09-fpxko8OC7kDorIE8shlxWz03Bivgo61BlapvHeABGOMsLulZjjJMe6tsFw6VjuptReA7Er-mOy1XRueEiqdrHRhjOEsirII1ulaSREq61khZZGR1-slbX4OQhoNEBAMRHMjEBn5gEu-mYYK2OlE139vxg3VeBO59kxb4KzCVLXxNZPOORWtZCyqjBytA9ass6oBsMIlQD5eZuTFZhg2FH4lMW3ornAOcNxCCSYy8mSI7-ZO1vmREbkV-a1b3R5p57Mk2o06_UKxg_--8pDcZcmKAw55RPaW_VV4BoBoaZ-nRP8D_KMO4w
  priority: 102
  providerName: Scholars Portal
Title The protective effect of glibenclamide in a model of hemorrhagic encephalopathy of prematurity
URI https://www.ncbi.nlm.nih.gov/pubmed/23667741
https://www.proquest.com/docview/1523705631
https://search.proquest.com/docview/1540708424
https://pubmed.ncbi.nlm.nih.gov/PMC3647482
https://doaj.org/article/daf39d29b2104a56ad627ccc8fb722f8
Volume 3
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Pa9swFH603WWXsa374a0LGoyxixtbki352JZ0YZASxgo9zejnkpHYJUsP_e_3JNuhKTsNjA-WDELvye_75KfvAXyy6EZKK5VW3riUF9Kl2iiTOo7hSTmbexkOCs-uyuk1_3ZT3BxAMZyFiUn7Ri9Pm9X6tFkuYm7l7dqMhzyx8Xx2ETTPuaTjQzjE8PuAov_uIRArsk7GhyGlH-tQbAEDCot1rEOtGsrKEnFPvheMomb_v4Dm43zJBwHo8jk865EjOetG-AIOXPMSjs8aZM3re_KZxFzOuEl-DD_R-mTeSTDg54x0GsWk9eRryCdpDPrB0jqybIgioRzaKrRNQ9btZqHwY0gm4TTjQq3aULL4PrTON0HeNRa7ewXXl5MfF9O0r6SQGiQkWySJTBRUe8uUstJVvqyQPUprDSI-7z2uYlHR0MlQZjXXTBhaGlFVliOCy9lrOGraxr0FIowoqkwpxajneea0qUopuCu0pZkQWQJfhimtbzvBjBqJRjBE_cgQCZyHKd91C0rX8UG7-VX39q6t8qyytNLITbkqSmVLKowx0mtBqZcJnAwGq_vl96dGUMIEQjuWJ_Bx14wLJ_wNUY1r70If5LKZ5JQn8Kaz724kg38kIPYsvzfU_Rb01SjO3fvmu_9-8z08pbHkBl7iBI62mzv3AYHPVo_gyfnkav59FDcO8D7jchSd_y-Ddwnq
link.rule.ids 230,314,727,780,784,864,885,2102,2221,21388,24318,27924,27925,33744,33745,43805,53791,53793,74302
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3Nb9MwFH-C7gAXBAxY2AAjIcQlWmo7cXxCG-oosFUV2qSdiPxJK41k67rD_nveS9JCJ4SUU-xIlt-3_fL7AbzzqEbGGpPq6EIq8zKk1hmXBonhyQQ_jCX9KHwyKcZn8ut5ft4fuF33bZUrn9g6at84OiPfxzgjFEZrMfx4eZUSaxTdrvYUGvdhi5DT8wFsHY4m0-_rUxbKh0SedZg-Auv7fUvMCxhdREtqnW-Eoxa1_1-p5t2Oyb9C0NFjeNTnjuygE_YTuBfqp7B9UGPd_OuWvWdtN2d7TL4NP1D-bNqBMKBDYx1KMWsi-0wdJbVDTZj7wOY1M4wI0S5obEx9t4uZQXfIRvQ_48xcNERafEuj0wUBvLZ0d8_g7Gh0-mmc9lwKqcOSZIllolA5t9ELY3wZdCw01o-l9w5zvhgj2rHSnCY5LryVVijHC6e09hJzuKF4DoO6qcMOMOVUrjNjjOBRDrNgnS5KJUNuPc-UyhL4sNrS6rKDzKiw1KDdr-7sfgKHtOXraYR13b5oFj-r3nQqb6LQnmuL1ak0eWF8wZVzroxWcR7LBPZWAqt6A7yu_qhLAm_Xw2g6dB9i6tDc0BysZrNScpnAi06-65VwURSYGePXakPyG0vdHKnnsxaemxD5Zclf_n9Zb-DB-PTkuDr-Mvm2Cw95y7KBj9qDwXJxE15hrrO0r3uF_g3QHgG_
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1bb9MwFD6CTkK8IGDAAgOMhBAvUVPbieMntEFLuVUVYtKeiHyllUYyuu5h_55zkrTQCSHlKXYky-dun3wfwEuPamSsMamOLqQyL0NqnXFpkBieTPCjWNKPwl9mxfREfjzNT_v-p4u-rXLjE1tH7RtHZ-RDjDNCYbQWo2Hs2yLm7yZvzn-lxCBFN609ncZN2MOomPEB7B2PZ_Ov2xMXyo1EnnX4PgJr_aElFgaMNKIluM53QlOL4P-vtPN69-Rf4WhyF-70eSQ76gR_D26E-j7sH9VYQ_-8Yq9Y29nZHpnvw3fUBTbvABnQubEOsZg1kb2n7pLaoVYsfWDLmhlG5GhnNDalHtzVwqBrZGP6t3FhzhoiML6i0fmKwF5b6rsHcDIZf3s7TXtehdRhebLGklGonNvohTG-DDoWGmvJ0nuH-V-MEW1aaU6THBfeSiuU44VTWnuJ-dxIPIRB3dThAJhyKteZMUbwKEdZsE4XpZIht55nSmUJvN5saXXewWdUWHbQ7lfXdj-BY9ry7TTCvW5fNKsfVW9GlTdRaM-1xUpVmrwwvuDKOVdGqziPZQKHG4FVvTFeVH9UJ4EX22E0I7obMXVoLmkOVrZZKblM4FEn3-1KuCgKzJLxa7Uj-Z2l7o7Uy0UL1U3o_LLkj_-_rOdwC3W5-vxh9ukJ3OYt4QY-6hAG69VleIppz9o-6_X5N6HWBew
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Protective+Effect+of+Glibenclamide+in+a+Model+of+Hemorrhagic+Encephalopathy+of+Prematurity&rft.jtitle=Brain+sciences&rft.au=Tosun%2C+Cigdem&rft.au=Koltz%2C+Michael+T.&rft.au=Kurland%2C+David+B.&rft.au=Ijaz%2C+Hina&rft.date=2013-03-07&rft.pub=MDPI&rft.eissn=2076-3425&rft.volume=3&rft.issue=1&rft.spage=215&rft.epage=238&rft_id=info:doi/10.3390%2Fbrainsci3010215&rft_id=info%3Apmid%2F23667741&rft.externalDBID=PMC3647482
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2076-3425&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2076-3425&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2076-3425&client=summon