Topical Tenofovir, a Microbicide Effective against HIV, Inhibits Herpes Simplex Virus-2 Replication - Andrei, Graciela; Lisco, Andrea; Vanpouille, Christophe; Introini, Andrea; Balestra, Emanuela; van den Oord, Joost; Cihlar, Tomas; Perno, Carlo-Federico; Snoeck, Robert; Margolis, Leonid; Balzarini, Jan (Cell host & microbe, 2011)
Keywords: Adenine - administration & dosage; Adenine - analogs & derivatives; Administration, Topical; Animals; Anti-Infective Agents - administration & dosage; antiviral properties; Cells, Cultured; death; DNA, Viral - chemistry; DNA, Viral - genetics; DNA-Directed DNA Polymerase; drugs; Exodeoxyribonucleases - antagonists & inhibitors; fibroblasts; gels; Herpes Genitalis - prevention & control; Herpes Genitalis - virology; herpes simplex; Herpesvirus 2, Human - drug effects; HIV Reverse Transcriptase - antagonists & inhibitors; Human alphaherpesvirus 2; Human immunodeficiency virus; Humans; keratinocytes; metabolites; Mice; Molecular Sequence Data; Nucleic Acid Synthesis Inhibitors; oral administration; Organophosphonates - administration & dosage; Sequence Analysis, DNA; Tenofovir; Thymidine Kinase - genetics; Viral Proteins - antagonists & inhibitors; Viral Proteins - genetics