Comparative In vitro antibacterial activity of nemonoxacin and other fluoroquinolones in correlation with resistant mechanisms in contemporary methicillin-resistant Staphylococcus aureus blood isolates in Taiwan

• Published in: Annals of clinical microbiology and antimicrobials Vol. 24; no. 1; pp. 5 - 10
• Main Authors: Chen, Pao -Yu, Ho, Mao-Wang, Lu, Po-Liang, Tang, Hung-Jen, Sy, Cheng Len, Wang, Jann-Tay
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.01.2025; BioMed Central; BMC
• Subjects: Anti-Bacterial Agents - pharmacology; Causes of; Ciprofloxacin; Distribution; Drug resistance in microorganisms; Drug Resistance, Bacterial; Drug therapy; Fluoroquinolones - pharmacology; Genetic aspects; Genotype; Humans; Identification and classification; Levofloxacin; Methicillin-Resistant Staphylococcus aureus - drug effects; Methicillin-Resistant Staphylococcus aureus - genetics; Methicillin-Resistant Staphylococcus aureus - isolation & purification; Microbial Sensitivity Tests; Moxifloxacin; Quinolone antibacterial agents; Quinolone resistance determination regions; Quinolones; Quinolones - pharmacology; Risk factors; Sequence type 8; Staphylococcal Infections - drug therapy; Staphylococcal Infections - microbiology; Staphylococcus aureus; Staphylococcus aureus infections; Taiwan; Testing; Taiwan; Levofloxacin; Sequence type 8; Quinolone resistance determination regions; Moxifloxacin; Ciprofloxacin

Nemonoxacin is a new quinolone with an antibacterial efficacy against methicillin-resistant Staphylococcus aureus (MRSA). Certain sequence types (STs) have been emerging in Taiwan, including fluoroquinolone-resistant ST8/USA300. It's an urgent need to determine nemonoxacin susceptibility agains...