Baicalin protects neonatal rat brains against hypoxic-ischemic injury by upregulating glutamate transporter 1 via the phosphoinositide 3-kinase/protein kinase B signaling pathway
Baicalin is a flavonoid compound extracted from Scutellaria baicalensis root. Recent evidence indicates that baicalin is neuroprotective in models of ischemic stroke. Here, we investigate the neuroprotective effect of baicalin in a neonatal rat model of hypoxic-ischemic encephalopathy. Seven-day-old...
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| Published in | Neural regeneration research Vol. 12; no. 10; pp. 1625 - 1631 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
India
Medknow Publications and Media Pvt. Ltd
01.10.2017
Medknow Publications & Media Pvt. Ltd Medknow Publications & Media Pvt Ltd Wolters Kluwer Medknow Publications |
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| Online Access | Get full text |
| ISSN | 1673-5374 1876-7958 |
| DOI | 10.4103/1673-5374.217335 |
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| Abstract | Baicalin is a flavonoid compound extracted from Scutellaria baicalensis root. Recent evidence indicates that baicalin is neuroprotective in models of ischemic stroke. Here, we investigate the neuroprotective effect of baicalin in a neonatal rat model of hypoxic-ischemic encephalopathy. Seven-day-old pups underwent left common carotid artery ligation followed by hypoxia (8% oxygen at 37°C) for 2 hours, before being injected with baicalin (120 mg/kg intraperitoneally) and examined 24 hours later. Baicalin effectively reduced cerebral infarct volume and neuronal loss, inhibited apoptosis, and upregulated the expression of p-Akt and glutamate transporter 1. Intracerebroventricular injection of the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) inhibitor LY294002 30 minutes before injury blocked the effect of baicalin on p-Akt and glutamate transporter 1, and weakened the associated neuroprotective effect. Our findings provide the first evidence, to our knowledge that baicalin can protect neonatal rat brains against hypoxic-ischemic injury by upregulating glutamate transporter 1 via the PI3K/Akt signaling pathway. |
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| AbstractList | Baicalin is a flavonoid compound extracted from Scutellaria baicalensis root. Recent evidence indicates that baicalin is neuroprotective in models of ischemic stroke. Here, we investigate the neuroprotective effect of baicalin in a neonatal rat model of hypoxic-ischemic encephalopathy. Seven-day-old pups underwent left common carotid artery ligation followed by hypoxia (8% oxygen at 37°C) for 2 hours, before being injected with baicalin (120 mg/kg intraperitoneally) and examined 24 hours later. Baicalin effectively reduced cerebral infarct volume and neuronal loss, inhibited apoptosis, and upregulated the expression of p-Akt and glutamate transporter 1. Intracerebroventricular injection of the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) inhibitor LY294002 30 minutes before injury blocked the effect of baicalin on p-Akt and glutamate transporter 1, and weakened the associated neuroprotective effect. Our findings provide the first evidence, to our knowledge that baicalin can protect neonatal rat brains against hypoxic-ischemic injury by upregulating glutamate transporter 1 via the PI3K/Akt signaling pathway. Baicalin is a flavonoid compound extracted from Scutellaria baicalensis root. Recent evidence indicates that baicalin is neuroprotective in models of ischemic stroke. Here, we investigate the neuroprotective effect of baicalin in a neonatal rat model of hypoxic-ischemic encephalopathy. Seven-day-old pups underwent left common carotid artery ligation followed by hypoxia (8% oxygen at 37°C) for 2 hours, before being injected with baicalin (120 mg/kg intraperitoneally) and examined 24 hours later. Baicalin effectively reduced cerebral infarct volume and neuronal loss, inhibited apoptosis, and upregulated the expression of p-Akt and glutamate transporter 1. Intracerebroventricular injection of the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) inhibitor LY294002 30 minutes before injury blocked the effect of baicalin on p-Akt and glutamate transporter 1, and weakened the associated neuroprotective effect. Our findings provide the first evidence, to our knowledge that baicalin can protect neonatal rat brains against hypoxic-ischemic injury by upregulating glutamate transporter 1 via the PI3K/Akt signaling pathway.Baicalin is a flavonoid compound extracted from Scutellaria baicalensis root. Recent evidence indicates that baicalin is neuroprotective in models of ischemic stroke. Here, we investigate the neuroprotective effect of baicalin in a neonatal rat model of hypoxic-ischemic encephalopathy. Seven-day-old pups underwent left common carotid artery ligation followed by hypoxia (8% oxygen at 37°C) for 2 hours, before being injected with baicalin (120 mg/kg intraperitoneally) and examined 24 hours later. Baicalin effectively reduced cerebral infarct volume and neuronal loss, inhibited apoptosis, and upregulated the expression of p-Akt and glutamate transporter 1. Intracerebroventricular injection of the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) inhibitor LY294002 30 minutes before injury blocked the effect of baicalin on p-Akt and glutamate transporter 1, and weakened the associated neuroprotective effect. Our findings provide the first evidence, to our knowledge that baicalin can protect neonatal rat brains against hypoxic-ischemic injury by upregulating glutamate transporter 1 via the PI3K/Akt signaling pathway. Baicalin is a flavonoid compound extracted from Scutellaria baicalensis root. Recent evidence indicates that baicalin is neuroprotective in models of ischemic stroke. Here, we investigate the neuroprotective effect of baicalin in a neonatal rat model of hypoxic-ischemic encephalopathy. Seven-day-old pups underwent left common carotid artery ligation followed by hypoxia (8% oxygen at 37°C) for 2 hours, before being injected with baicalin (120 mg/kg intraperitoneally) and examined 24 hours later. Baicalin effectively reduced cerebral infarct volume and neuronal loss, inhibited apoptosis, and upregulated the expression of p-Akt and glutamate transporter 1. Intracerebroventricular injection of the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) inhibitor LY294002 30 minutes before injury blocked the effect of baicalin on p-Akt and glutamate transporter 1, and weakened the associated neuroprotective effect. Our findings provide the first evidence, to our knowledge that baicalin can protect neonatal rat brains against hypoxic-ischemic injury by upregulating glutamate transporter 1 via the PI3K/Akt signaling pathway. |
| Audience | Academic |
| Author | Zhou, Zhi-qing Wen, Zhi-li Chen, Qi-wen Huang, Zheng-gang Li, Yong-liang Ao, Zhen-bo Yan, Xiao-hua Xiao, Bing |
| AuthorAffiliation | 5 Department of Neurosurgery, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China 1 Department of Pediatrics, the Second People's Hospital of Huaihua City, Huaihua, Hunan Province, China 4 Department of Pediatrics, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China 2 Department of Oncology, the Second People's Hospital of Huaihua City, Huaihua, Hunan Province, China 3 Department of Gastroenterology, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China |
| AuthorAffiliation_xml | – name: 5 Department of Neurosurgery, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China – name: 2 Department of Oncology, the Second People's Hospital of Huaihua City, Huaihua, Hunan Province, China – name: 1 Department of Pediatrics, the Second People's Hospital of Huaihua City, Huaihua, Hunan Province, China – name: 3 Department of Gastroenterology, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China – name: 4 Department of Pediatrics, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China |
| Author_xml | – sequence: 1 givenname: Zhi-qing surname: Zhou fullname: Zhou, Zhi-qing – sequence: 2 givenname: Yong-liang surname: Li fullname: Li, Yong-liang – sequence: 3 givenname: Zhen-bo surname: Ao fullname: Ao, Zhen-bo – sequence: 4 givenname: Zhi-li surname: Wen fullname: Wen, Zhi-li – sequence: 5 givenname: Qi-wen surname: Chen fullname: Chen, Qi-wen – sequence: 6 givenname: Zheng-gang surname: Huang fullname: Huang, Zheng-gang – sequence: 7 givenname: Bing surname: Xiao fullname: Xiao, Bing – sequence: 8 givenname: Xiao-hua surname: Yan fullname: Yan, Xiao-hua |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29171427$$D View this record in MEDLINE/PubMed |
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| Keywords | glutamate transporter 1 nerve regeneration; baicalin; hypoxia ischemia; PI3K/Akt signaling pathway; glutamate transporter 1; excitotoxicity; neonatal rats; apoptosis; neural regeneration neural regeneration baicalin apoptosis nerve regeneration hypoxia ischemia neonatal rats PI3K/Akt signaling pathway excitotoxicity |
| Language | English |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Author contributions: XHY was responsible for the design of the experiments. QWC was responsible for establishing the animal model. ZQZ and YLL were responsible for molecular biology experiment. BX was responsible for experimental operation in 2,3,5-triphenyltetrazolium chloride, Nissl staining and terminal deoxynucleotidyl transferase dUTP nick end labeling staining. ZGH was responsible for data collection. ZLW was responsible for statistical analysis. ZQZ wrote the paper. All authors approved the final version of the paper. |
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| Snippet | Baicalin is a flavonoid compound extracted from Scutellaria baicalensis root. Recent evidence indicates that baicalin is neuroprotective in models of ischemic... |
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| SubjectTerms | Alzheimer's disease Brain Brain damage Care and treatment Carotid arteries Composition Drug dosages Encephalopathy Flavonoids Health aspects Hypoxia Ischemia Kinases Medicinal plants nerve regeneration; baicalin; hypoxia ischemia; PI3K/Akt signaling pathway; glutamate transporter 1; excitotoxicity; neonatal rats; apoptosis; neural regeneration Neurotransmitter receptors Proteins Rodents Skullcap |
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| Title | Baicalin protects neonatal rat brains against hypoxic-ischemic injury by upregulating glutamate transporter 1 via the phosphoinositide 3-kinase/protein kinase B signaling pathway |
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