Regulation of Tumor Immunity by Lysophosphatidic Acid

• Published in: Cancers Vol. 12; no. 5; p. 1202
• Main Authors: Lee, Sue Chin, Dacheux, Mélanie A., Norman, Derek D., Balázs, Louisa, Torres, Raul M., Augelli-Szafran, Corinne E., Tigyi, Gábor J.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.05.2020; MDPI
• Subjects: Adipocytes; Angiogenesis; Antigens; Cancer; Cytokines; Cytotoxicity; Enzymes; Extracellular matrix; Fibroblasts; Granulocytes; Immune system; Immunomodulation; Investigations; Kinases; Lymphocytes; Lysophosphatidic acid; Metastases; Metastasis; Neutrophils; Ovarian cancer; Peptides; Proteins; Review; T cell receptors; Tumors; lysophosphatidic acid; LPAR5; autotaxin; immune checkpoint; immune cells; immunosuppression; tumor microenvironment; LPA; cytotoxic T cells; immunosurveillance; immunoediting; tumor-associated macrophages

The tumor microenvironment (TME) may be best conceptualized as an ecosystem comprised of cancer cells interacting with a multitude of stromal components such as the extracellular matrix (ECM), blood and lymphatic networks, fibroblasts, adipocytes, and cells of the immune system. At the center of thi...