Long noncoding RNAs are generated from the mitochondrial genome and regulated by nuclear-encoded proteins

Human mitochondrial long noncoding RNAs (lncRNAs) have not been described to date. By analysis of deep-sequencing data we have identified three lncRNAs generated from the mitochondrial genome and confirmed their expression by Northern blotting and strand-specific qRT-PCR. We show that the abundance...

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Published inRNA (Cambridge) Vol. 17; no. 12; pp. 2085 - 2093
Main Authors Rackham, Oliver, Shearwood, Anne-Marie J, Mercer, Tim R, Davies, Stefan M K, Mattick, John S, Filipovska, Aleksandra
Format Journal Article
LanguageEnglish
Published United States Cold Spring Harbor Laboratory Press 01.12.2011
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Abstract Human mitochondrial long noncoding RNAs (lncRNAs) have not been described to date. By analysis of deep-sequencing data we have identified three lncRNAs generated from the mitochondrial genome and confirmed their expression by Northern blotting and strand-specific qRT-PCR. We show that the abundance of these lncRNAs is comparable to their complementary mRNAs and that nuclear-encoded mitochondrial proteins involved in RNA processing regulate their expression. We also identify the 5' and 3' transcript ends of the three lncRNAs and show that mitochondrial RNase P protein 1 (MRPP1) is important for the processing of these transcripts. Finally, we show that mitochondrial lncRNAs form intermolecular duplexes and that their abundance is cell- and tissue-specific, suggesting a functional role in the regulation of mitochondrial gene expression.
AbstractList Human mitochondrial long noncoding RNAs (lncRNAs) have not been described to date. By analysis of deep-sequencing data we have identified three lncRNAs generated from the mitochondrial genome and confirmed their expression by Northern blotting and strand-specific qRT-PCR. We show that the abundance of these lncRNAs is comparable to their complementary mRNAs and that nuclear-encoded mitochondrial proteins involved in RNA processing regulate their expression. We also identify the 5' and 3' transcript ends of the three lncRNAs and show that mitochondrial RNase P protein 1 (MRPP1) is important for the processing of these transcripts. Finally, we show that mitochondrial lncRNAs form intermolecular duplexes and that their abundance is cell- and tissue-specific, suggesting a functional role in the regulation of mitochondrial gene expression.
Human mitochondrial long noncoding RNAs (lncRNAs) have not been described to date. By analysis of deep-sequencing data, the authors identified three lncRNAs generated from the mitochondrial genome and confirmed their expression by northern blotting and strand-specific qRT-PCR. They show that the abundance of these lncRNAs is comparable to their complementary mRNAs and that nuclear-encoded mitochondrial proteins involved in RNA processing regulate their expression. Finally, they show that mitochondrial lncRNAs form intermolecular duplexes and that their abundance is cell- and tissue-specific, suggesting a functional role in the regulation of mitochondrial gene expression. Human mitochondrial long noncoding RNAs (lncRNAs) have not been described to date. By analysis of deep-sequencing data we have identified three lncRNAs generated from the mitochondrial genome and confirmed their expression by Northern blotting and strand-specific qRT–PCR. We show that the abundance of these lncRNAs is comparable to their complementary mRNAs and that nuclear-encoded mitochondrial proteins involved in RNA processing regulate their expression. We also identify the 5′ and 3′ transcript ends of the three lncRNAs and show that mitochondrial RNase P protein 1 (MRPP1) is important for the processing of these transcripts. Finally, we show that mitochondrial lncRNAs form intermolecular duplexes and that their abundance is cell- and tissue-specific, suggesting a functional role in the regulation of mitochondrial gene expression.
Author Filipovska, Aleksandra
Mercer, Tim R
Rackham, Oliver
Shearwood, Anne-Marie J
Davies, Stefan M K
Mattick, John S
AuthorAffiliation 1 Western Australian Institute for Medical Research and Centre for Medical Research, The University of Western Australia, Perth, Western Australia 6000, Australia
2 Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
AuthorAffiliation_xml – name: 1 Western Australian Institute for Medical Research and Centre for Medical Research, The University of Western Australia, Perth, Western Australia 6000, Australia
– name: 2 Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
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  fullname: Shearwood, Anne-Marie J
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Snippet Human mitochondrial long noncoding RNAs (lncRNAs) have not been described to date. By analysis of deep-sequencing data we have identified three lncRNAs...
Human mitochondrial long noncoding RNAs (lncRNAs) have not been described to date. By analysis of deep-sequencing data, the authors identified three lncRNAs...
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StartPage 2085
SubjectTerms Base Sequence
Cell Nucleus - genetics
Gene Expression Regulation
Genome, Mitochondrial
HeLa Cells
Humans
Mitochondria - genetics
Mitochondria - metabolism
Mitochondrial Proteins - genetics
Mitochondrial Proteins - metabolism
Molecular Sequence Data
Nucleic Acid Conformation
Organ Specificity - genetics
Ribonuclease P - genetics
Ribonuclease P - metabolism
RNA Stability
RNA, Untranslated - genetics
RNA, Untranslated - metabolism
Title Long noncoding RNAs are generated from the mitochondrial genome and regulated by nuclear-encoded proteins
URI https://www.ncbi.nlm.nih.gov/pubmed/22028365
https://search.proquest.com/docview/905675232
https://search.proquest.com/docview/911162446
https://pubmed.ncbi.nlm.nih.gov/PMC3222122
Volume 17
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