Role of CRTC2 in Metabolic Homeostasis: Key Regulator of Whole-Body Energy Metabolism?
Cyclic adenosine monophosphate (cAMP) signaling is critical for regulating metabolic homeostasis in mammals. In particular, transcriptional regulation by cAMP response element-binding protein (CREB) and its coactivator, CREB-regulated transcription coactivator (CRTC), is essential for controlling th...
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Published in | Diabetes & metabolism journal Vol. 44; no. 4; pp. 498 - 508 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Korea (South)
Korean Diabetes Association
01.08.2020
대한당뇨병학회 |
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Abstract | Cyclic adenosine monophosphate (cAMP) signaling is critical for regulating metabolic homeostasis in mammals. In particular, transcriptional regulation by cAMP response element-binding protein (CREB) and its coactivator, CREB-regulated transcription coactivator (CRTC), is essential for controlling the expression of critical enzymes in the metabolic process, leading to more chronic changes in metabolic flux. Among the CRTC isoforms, CRTC2 is predominantly expressed in peripheral tissues and has been shown to be associated with various metabolic pathways in tissue-specific manners. While initial reports showed the physiological role of CRTC2 in regulating gluconeogenesis in the liver, recent studies have further delineated the role of this transcriptional coactivator in the regulation of glucose and lipid metabolism in various tissues, including the liver, pancreatic islets, endocrine tissues of the small intestines, and adipose tissues. In this review, we discuss recent studies that have utilized knockout mouse models to delineate the role of CRTC2 in the regulation of metabolic homeostasis. |
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AbstractList | Cyclic adenosine monophosphate (cAMP) signaling is critical for regulating metabolic homeostasis in mammals. In particular, transcriptional regulation by cAMP response element-binding protein (CREB) and its coactivator, CREB-regulated transcription coactivator (CRTC), is essential for controlling the expression of critical enzymes in the metabolic process, leading to more chronic changes in metabolic flux. Among the CRTC isoforms, CRTC2 is predominantly expressed in peripheral tissues and has been shown to be associated with various metabolic pathways in tissue-specific manners. While initial reports showed the physiological role of CRTC2 in regulating gluconeogenesis in the liver, recent studies have further delineated the role of this transcriptional coactivator in the regulation of glucose and lipid metabolism in various tissues, including the liver, pancreatic islets, endocrine tissues of the small intestines, and adipose tissues. In this review, we discuss recent studies that have utilized knockout mouse models to delineate the role of CRTC2 in the regulation of metabolic homeostasis. KCI Citation Count: 0 Cyclic adenosine monophosphate (cAMP) signaling is critical for regulating metabolic homeostasis in mammals. In particular, transcriptional regulation by cAMP response element-binding protein (CREB) and its coactivator, CREB-regulated transcription coactivator (CRTC), is essential for controlling the expression of critical enzymes in the metabolic process, leading to more chronic changes in metabolic flux. Among the CRTC isoforms, CRTC2 is predominantly expressed in peripheral tissues and has been shown to be associated with various metabolic pathways in tissue-specific manners. While initial reports showed the physiological role of CRTC2 in regulating gluconeogenesis in the liver, recent studies have further delineated the role of this transcriptional coactivator in the regulation of glucose and lipid metabolism in various tissues, including the liver, pancreatic islets, endocrine tissues of the small intestines, and adipose tissues. In this review, we discuss recent studies that have utilized knockout mouse models to delineate the role of CRTC2 in the regulation of metabolic homeostasis. |
Author | Koo, Seung Hoi Kwon, Yongmin Han, Hye Sook |
AuthorAffiliation | Division of Life Sciences, College of Life Sciences & Biotechnology, Korea University, Seoul, Korea |
AuthorAffiliation_xml | – name: Division of Life Sciences, College of Life Sciences & Biotechnology, Korea University, Seoul, Korea |
Author_xml | – sequence: 1 givenname: Hye Sook orcidid: 0000-0002-6824-9174 surname: Han fullname: Han, Hye Sook organization: Division of Life Sciences, College of Life Sciences & Biotechnology, Korea University, Seoul, Korea – sequence: 2 givenname: Yongmin surname: Kwon fullname: Kwon, Yongmin organization: Division of Life Sciences, College of Life Sciences & Biotechnology, Korea University, Seoul, Korea – sequence: 3 givenname: Seung Hoi orcidid: 0000-0001-8769-2879 surname: Koo fullname: Koo, Seung Hoi email: koohoi@korea.ac.kr organization: Division of Life Sciences, College of Life Sciences & Biotechnology, Korea University, Seoul, Korea. koohoi@korea.ac.kr |
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Keywords | Cyclic AMP Energy metabolism Transcription, genetic CRTC2 protein, human Crtc2 protein, mouse |
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Snippet | Cyclic adenosine monophosphate (cAMP) signaling is critical for regulating metabolic homeostasis in mammals. In particular, transcriptional regulation by cAMP... |
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SubjectTerms | crtc2 protein, human crtc2 protein, mouse cyclic amp energy metabolism Review transcription, genetic 내과학 |
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Title | Role of CRTC2 in Metabolic Homeostasis: Key Regulator of Whole-Body Energy Metabolism? |
URI | https://www.ncbi.nlm.nih.gov/pubmed/32174060 https://search.proquest.com/docview/2377679084 https://pubmed.ncbi.nlm.nih.gov/PMC7453979 https://doaj.org/article/6ac98d4a1f4b4e438213d61bb9984528 https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002616237 |
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ispartofPNX | Diabetes and Metabolism Journal, 2020, 44(4), 180, pp.498-508 |
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