Progression of fibrosis in chronic hepatitis C

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 124; no. 1; p. 97
• Main Authors: Ghany, Marc G, Kleiner, David E, Alter, Harvey, Doo, Edward, Khokar, Farooq, Promrat, Kittichai, Herion, David, Park, Yoon, Liang, T Jake, Hoofnagle, Jay H
• Format: Journal Article
• Language: English
• Published: United States 01.01.2003
• Subjects: Adult; Aged; Alanine Transaminase - blood; Biopsy; Disease Progression; Female; Follow-Up Studies; Hepatitis C, Chronic - complications; Humans; Liver - pathology; Liver Cirrhosis - blood; Liver Cirrhosis - pathology; Liver Cirrhosis - virology; Male; Middle Aged; Time Factors

Fibrosis is the hallmark of hepatic cirrhosis, worsening of which is probably the best surrogate marker for progression of chronic liver disease. We evaluated a large cohort of patients with chronic hepatitis C (CHC) using liver histology to assess the rate and predictors of progression of fibrosis....