Conserved glycolipid termini in capsular polysaccharides synthesized by ATP-binding cassette transporter-dependent pathways in Gram-negative pathogens

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 110; no. 19; pp. 7868 - 7873
• Main Authors: Willis, Lisa M., Stupak, Jacek, Richards, Michele R., Lowary, Todd L., Li, Jianjun, Whitfield, Chris
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 07.05.2013; National Acad Sciences
• Subjects: Adenosine triphosphatase; Adenosine Triphosphate - metabolism; ATP binding cassette transporters; ATP-Binding Cassette Transporters - metabolism; Bacteria; Bacterial Capsules - metabolism; Binding sites; Biochemistry; Biological Sciences; Biological Transport; Biosynthesis; Capsules; Carbohydrates; Enzymes; Escherichia coli; Escherichia coli - metabolism; Glycolipids; Glycolipids - metabolism; Gram-negative bacteria; Gram-Negative Bacteria - metabolism; Lipids; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methylation; Mutation; Neisseria meningitidis - metabolism; Pathogens; Polysaccharides; Polysaccharides - metabolism; Virulence Factors - metabolism; capsule assembly; polysaccharide export

Bacterial capsules are surface layers made of long-chain polysaccharides. They are anchored to the outer membrane of many Gram-negative bacteria, including pathogens such as Escherichia coli , Neisseria meningitidis , Haemophilus influenzae , and Pasteurella multocida . Capsules protect pathogens fr...