A Miniaturized Platform for Multiplexed Drug Response Imaging in Live Tumors

• Published in: Cancers Vol. 13; no. 4; p. 653
• Main Authors: Bhagavatula, Sharath, Thompson, Devon, Ahn, Sebastian W, Upadhyaya, Kunj, Lammers, Alex, Deans, Kyle, Dominas, Christine, Ferland, Benjamin, Valvo, Veronica, Liu, Guigen, Jonas, Oliver
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 06.02.2021; MDPI
• Subjects: Animal models; Apoptosis; Cancer therapies; Cell death; Chemotherapy; Customization; drug screening; Drugs; Fluorescence microscopy; Microscopy; miniaturized optical imaging; personalized oncology; Polyethylene glycol; Surgery; Tumors; drug screening; personalized oncology; miniaturized optical imaging

By observing the activity of anti-cancer agents directly in tumors, there is potential to greatly expand our understanding of drug response and develop more personalized cancer treatments. Implantable microdevices (IMD) have been recently developed to deliver microdoses of chemotherapeutic agents lo...