Gummi Formulations Comprising Amenamevir Solid Dispersions with Polyvinyl Alcohol

• Published in: Chemical & pharmaceutical bulletin Vol. 69; no. 9; pp. 862 - 871
• Main Authors: Umemoto, Yoshiaki, Tanaka, Shimako, Kambayashi, Atsushi, Sugimoto, Koki, Kashiwagura, Yasuharu, Namiki, Noriyuki, Uchida, Shinya
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 01.09.2021; Japan Science and Technology Agency
• Subjects: Absorption; amenamevir; Design of experiments; Dispersions; Dissolution; dog; Gelatin; gummi formulation; In vivo methods and tests; Polyvinyl alcohol; solid dispersion; Stability analysis

The aim of the present study was to determine whether solid dispersions (SDs) are applicable to gummi formulations. Amenamevir was selected as a model of a poorly water-soluble drug, and polyvinyl alcohols (PVAs) with various degrees of hydrolysis (PVA 66, PVA 80, PVA 88, and PVA 66/88) were used as...