Changes of Fecal Bifidobacterium Species in Adult Patients with Hepatitis B Virus-Induced Chronic Liver Disease

The beneficial effects of Bifidobacteria on health have been widely accepted. Patients with chronic liver disease have varying degrees of intestinal microflora imbalance with a decrease of total Bifidobacterial counts. Since different properties have been attributed to different Bifidobacterium spec...

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Published inMicrobial ecology Vol. 63; no. 2; pp. 304 - 313
Main Authors Xu, Min, Wang, Baohong, Fu, Yiqi, Chen, Yanfei, Yang, Fengling, Lu, Haifeng, Chen, Yunbo, Xu, Jiali, Li, Lanjuan
Format Journal Article
LanguageEnglish
Published New York Springer Science + Business Media 01.02.2012
Springer-Verlag
Springer
Springer Nature B.V
Subjects
administration & dosage
Adult
bacteria
Bifidobacterium
Bifidobacterium - classification
Bifidobacterium - genetics
Bifidobacterium - isolation & purification
Bifidobacterium catenulatum
Bifidobacterium dentium
Bifidobacterium longum
Bifidobacterium pseudocatenulatum
Biological and medical sciences
Biomedical and Life Sciences
China
chronic diseases
Chronic hepatitis
chronic hepatitis B
Cirrhosis
classification
clones
Composition
Denaturing Gradient Gel Electrophoresis
DNA, Bacterial
DNA, Bacterial - genetics
Dysbacteriosis
Ecology
Electrophoresis
Feces
Feces - microbiology
Female
Fundamental and applied biological sciences. Psychology
Gel electrophoresis
genetics
Geoecology/Natural Processes
Hepatitis
Hepatitis B
Hepatitis B virus
Hepatitis B virus - physiology
Hepatitis B, Chronic
Hepatitis B, Chronic - microbiology
Hepatitis B, Chronic - virology
HOST MICROBE INTERACTIONS
Humans
Intestinal microflora
intestinal microorganisms
Intestines
Intestines - microbiology
isolation & purification
Libraries
Life Sciences
Liver
Liver Cirrhosis
Liver Cirrhosis - microbiology
Liver Cirrhosis - virology
Liver diseases
Male
Microbial Ecology
Microbial flora
Microbiology
Microbiota
Middle Aged
Molecular Sequence Data
Nature Conservation
Nucleotide sequence
Opportunist infection
pathogens
patients
Phylogeny
physiology
Polymerase Chain Reaction
Probiotics
Probiotics - administration & dosage
Real time
Real-Time Polymerase Chain Reaction
RNA, Ribosomal, 16S
RNA, Ribosomal, 16S - genetics
Sequence Analysis, DNA
Species
Species Specificity
virology
Viruses
Water Quality/Water Pollution
China
Minimal Hepatic Encephalopathy
Clone Library
Bifidobacterium Species
Bifidobacterium Longum
Bifidobacterium Bifidum
Human
Probiotic
Bifidobacterium
Disease
Eubacteria
Liver
Orthohepadnavirus
Bifidobacteriaceae
Ecology
Virus
Chronic
Hepadnaviridae
Actinobacteridae
Actinobacteria
Bacteria
Bifidobacteriales
Feces
Hepatitis B virus
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Abstract The beneficial effects of Bifidobacteria on health have been widely accepted. Patients with chronic liver disease have varying degrees of intestinal microflora imbalance with a decrease of total Bifidobacterial counts. Since different properties have been attributed to different Bifidobacterium species and there is no information available for the detailed changes in the genus Bifidobacterium in patients with chronic liver disease heretofore, it is meaningful to investigate the structure of this bacterium at the species level in these patients. The aim of this study was to characterize the composition of intestinal Bifidobacterium in patients with hepatitis B virus-induced chronic liver disease. Nested-PCR-based denaturing gradient gel electrophoresis (PCR-DGGE), clone library, and real-time quantitative PCR were performed on the fecal samples of 16 patients with chronic hepatitis B (CHB patients), 16 patients with hepatitis B virus-related cirrhosis (HBV cirrhotics), and 15 healthy subjects (Controls). Though there was no significant difference in the diversity among the three groups (P= 0.196), Bifidobacterium dentium seems to be specifically enhanced in patients as the PCR-DGGE profiles showed, which was further validated by clone library and real-time quantitative PCR. In contrast to the B. dentium, Bifidobacterium catenulatum/Bifidobacterium pseudocatenulatum were detected less frequently in the predominant profile and by quantitative PCR in HBV cirrhotics than in the controls, and the level of this species was also significantly different between these two groups (P= 0.023). Although having no quantitative difference among the three groups, Bifidobacterium longum was less commonly detected in HBV cirrhotics than in CHB patients and Controls by quantitative PCR (P= 0.011). Thus, the composition of intestinal Bifidobacterium was deeply altered in CHB and HBV cirrhotic patients with a shift from beneficial species to opportunistic pathogens. The results provide further insights into the dysbiosis of the intestinal microbiota in patients with hepatitis B virusinduced chronic liver disease and might potentially serve as guidance for the probiotics interventions of these diseases.
AbstractList The beneficial effects of Bifidobacteria on health have been widely accepted. Patients with chronic liver disease have varying degrees of intestinal microflora imbalance with a decrease of total Bifidobacterial counts. Since different properties have been attributed to different Bifidobacterium species and there is no information available for the detailed changes in the genus Bifidobacterium in patients with chronic liver disease heretofore, it is meaningful to investigate the structure of this bacterium at the species level in these patients. The aim of this study was to characterize the composition of intestinal Bifidobacterium in patients with hepatitis B virus-induced chronic liver disease. Nested-PCR-based denaturing gradient gel electrophoresis (PCR-DGGE), clone library, and real-time quantitative PCR were performed on the fecal samples of 16 patients with chronic hepatitis B (CHB patients), 16 patients with hepatitis B virus-related cirrhosis (HBV cirrhotics), and 15 healthy subjects (Controls). Though there was no significant difference in the diversity among the three groups (P=0.196), Bifidobacterium dentium seems to be specifically enhanced in patients as the PCR-DGGE profiles showed, which was further validated by clone library and real-time quantitative PCR. In contrast to the B. dentium, Bifidobacterium catenulatum/Bifidobacterium pseudocatenulatum were detected less frequently in the predominant profile and by quantitative PCR in HBV cirrhotics than in the controls, and the level of this species was also significantly different between these two groups (P=0.023). Although having no quantitative difference among the three groups, Bifidobacterium longum was less commonly detected in HBV cirrhotics than in CHB patients and Controls by quantitative PCR (P=0.011). Thus, the composition of intestinal Bifidobacterium was deeply altered in CHB and HBV cirrhotic patients with a shift from beneficial species to opportunistic pathogens. The results provide further insights into the dysbiosis of the intestinal microbiota in patients with hepatitis B virus-induced chronic liver disease and might potentially serve as guidance for the probiotics interventions of these diseases.
The beneficial effects of Bifidobacteria on health have been widely accepted. Patients with chronic liver disease have varying degrees of intestinal microflora imbalance with a decrease of total Bifidobacterial counts. Since different properties have been attributed to different Bifidobacterium species and there is no information available for the detailed changes in the genus Bifidobacterium in patients with chronic liver disease heretofore, it is meaningful to investigate the structure of this bacterium at the species level in these patients. The aim of this study was to characterize the composition of intestinal Bifidobacterium in patients with hepatitis B virus-induced chronic liver disease. Nested-PCR-based denaturing gradient gel electrophoresis (PCR-DGGE), clone library, and real-time quantitative PCR were performed on the fecal samples of 16 patients with chronic hepatitis B (CHB patients), 16 patients with hepatitis B virus-related cirrhosis (HBV cirrhotics), and 15 healthy subjects (Controls). Though there was no significant difference in the diversity among the three groups (P = 0.196), Bifidobacterium dentium seems to be specifically enhanced in patients as the PCR-DGGE profiles showed, which was further validated by clone library and real-time quantitative PCR. In contrast to the B. dentium, Bifidobacteriumcatenulatum/Bifidobacterium pseudocatenulatum were detected less frequently in the predominant profile and by quantitative PCR in HBV cirrhotics than in the controls, and the level of this species was also significantly different between these two groups (P = 0.023). Although having no quantitative difference among the three groups, Bifidobacterium longum was less commonly detected in HBV cirrhotics than in CHB patients and Controls by quantitative PCR (P = 0.011). Thus, the composition of intestinal Bifidobacterium was deeply altered in CHB and HBV cirrhotic patients with a shift from beneficial species to opportunistic pathogens. The results provide further insights into the dysbiosis of the intestinal microbiota in patients with hepatitis B virus-induced chronic liver disease and might potentially serve as guidance for the probiotics interventions of these diseases.
The beneficial effects of Bifidobacteria on health have been widely accepted. Patients with chronic liver disease have varying degrees of intestinal microflora imbalance with a decrease of total Bifidobacterial counts. Since different properties have been attributed to different Bifidobacterium species and there is no information available for the detailed changes in the genus Bifidobacterium in patients with chronic liver disease heretofore, it is meaningful to investigate the structure of this bacterium at the species level in these patients. The aim of this study was to characterize the composition of intestinal Bifidobacterium in patients with hepatitis B virus-induced chronic liver disease. Nested-PCR-based denaturing gradient gel electrophoresis (PCR-DGGE), clone library, and real-time quantitative PCR were performed on the fecal samples of 16 patients with chronic hepatitis B (CHB patients), 16 patients with hepatitis B virus-related cirrhosis (HBV cirrhotics), and 15 healthy subjects (Controls). Though there was no significant difference in the diversity among the three groups ( P  = 0.196), Bifidobacterium dentium seems to be specifically enhanced in patients as the PCR-DGGE profiles showed, which was further validated by clone library and real-time quantitative PCR. In contrast to the B. dentium , Bifidobacterium catenulatum/Bifidobacterium pseudocatenulatum were detected less frequently in the predominant profile and by quantitative PCR in HBV cirrhotics than in the controls, and the level of this species was also significantly different between these two groups ( P  = 0.023). Although having no quantitative difference among the three groups, Bifidobacterium longum was less commonly detected in HBV cirrhotics than in CHB patients and Controls by quantitative PCR ( P  = 0.011). Thus, the composition of intestinal Bifidobacterium was deeply altered in CHB and HBV cirrhotic patients with a shift from beneficial species to opportunistic pathogens. The results provide further insights into the dysbiosis of the intestinal microbiota in patients with hepatitis B virus-induced chronic liver disease and might potentially serve as guidance for the probiotics interventions of these diseases.
The beneficial effects of Bifidobacteria on health have been widely accepted. Patients with chronic liver disease have varying degrees of intestinal microflora imbalance with a decrease of total Bifidobacterial counts. Since different properties have been attributed to different Bifidobacterium species and there is no information available for the detailed changes in the genus Bifidobacterium in patients with chronic liver disease heretofore, it is meaningful to investigate the structure of this bacterium at the species level in these patients. The aim of this study was to characterize the composition of intestinal Bifidobacterium in patients with hepatitis B virus-induced chronic liver disease. Nested-PCR-based denaturing gradient gel electrophoresis (PCR-DGGE), clone library, and real-time quantitative PCR were performed on the fecal samples of 16 patients with chronic hepatitis B (CHB patients), 16 patients with hepatitis B virus-related cirrhosis (HBV cirrhotics), and 15 healthy subjects (Controls). Though there was no significant difference in the diversity among the three groups (P= 0.196), Bifidobacterium dentium seems to be specifically enhanced in patients as the PCR-DGGE profiles showed, which was further validated by clone library and real-time quantitative PCR. In contrast to the B. dentium, Bifidobacterium catenulatum/Bifidobacterium pseudocatenulatum were detected less frequently in the predominant profile and by quantitative PCR in HBV cirrhotics than in the controls, and the level of this species was also significantly different between these two groups (P= 0.023). Although having no quantitative difference among the three groups, Bifidobacterium longum was less commonly detected in HBV cirrhotics than in CHB patients and Controls by quantitative PCR (P= 0.011). Thus, the composition of intestinal Bifidobacterium was deeply altered in CHB and HBV cirrhotic patients with a shift from beneficial species to opportunistic pathogens. The results provide further insights into the dysbiosis of the intestinal microbiota in patients with hepatitis B virusinduced chronic liver disease and might potentially serve as guidance for the probiotics interventions of these diseases.
The beneficial effects of Bifidobacteria on health have been widely accepted. Patients with chronic liver disease have varying degrees of intestinal microflora imbalance with a decrease of total Bifidobacterial counts. Since different properties have been attributed to different Bifidobacterium species and there is no information available for the detailed changes in the genus Bifidobacterium in patients with chronic liver disease heretofore, it is meaningful to investigate the structure of this bacterium at the species level in these patients. The aim of this study was to characterize the composition of intestinal Bifidobacterium in patients with hepatitis B virus-induced chronic liver disease. Nested-PCR-based denaturing gradient gel electrophoresis (PCR-DGGE), clone library, and real-time quantitative PCR were performed on the fecal samples of 16 patients with chronic hepatitis B (CHB patients), 16 patients with hepatitis B virus-related cirrhosis (HBV cirrhotics), and 15 healthy subjects (Controls). Though there was no significant difference in the diversity among the three groups (P = 0.196), Bifidobacterium dentium seems to be specifically enhanced in patients as the PCR-DGGE profiles showed, which was further validated by clone library and real-time quantitative PCR. In contrast to the B. dentium, Bifidobacterium catenulatum/Bifidobacterium pseudocatenulatum were detected less frequently in the predominant profile and by quantitative PCR in HBV cirrhotics than in the controls, and the level of this species was also significantly different between these two groups (P = 0.023). Although having no quantitative difference among the three groups, Bifidobacterium longum was less commonly detected in HBV cirrhotics than in CHB patients and Controls by quantitative PCR (P = 0.011). Thus, the composition of intestinal Bifidobacterium was deeply altered in CHB and HBV cirrhotic patients with a shift from beneficial species to opportunistic pathogens. The results provide further insights into the dysbiosis of the intestinal microbiota in patients with hepatitis B virus-induced chronic liver disease and might potentially serve as guidance for the probiotics interventions of these diseases.The beneficial effects of Bifidobacteria on health have been widely accepted. Patients with chronic liver disease have varying degrees of intestinal microflora imbalance with a decrease of total Bifidobacterial counts. Since different properties have been attributed to different Bifidobacterium species and there is no information available for the detailed changes in the genus Bifidobacterium in patients with chronic liver disease heretofore, it is meaningful to investigate the structure of this bacterium at the species level in these patients. The aim of this study was to characterize the composition of intestinal Bifidobacterium in patients with hepatitis B virus-induced chronic liver disease. Nested-PCR-based denaturing gradient gel electrophoresis (PCR-DGGE), clone library, and real-time quantitative PCR were performed on the fecal samples of 16 patients with chronic hepatitis B (CHB patients), 16 patients with hepatitis B virus-related cirrhosis (HBV cirrhotics), and 15 healthy subjects (Controls). Though there was no significant difference in the diversity among the three groups (P = 0.196), Bifidobacterium dentium seems to be specifically enhanced in patients as the PCR-DGGE profiles showed, which was further validated by clone library and real-time quantitative PCR. In contrast to the B. dentium, Bifidobacterium catenulatum/Bifidobacterium pseudocatenulatum were detected less frequently in the predominant profile and by quantitative PCR in HBV cirrhotics than in the controls, and the level of this species was also significantly different between these two groups (P = 0.023). Although having no quantitative difference among the three groups, Bifidobacterium longum was less commonly detected in HBV cirrhotics than in CHB patients and Controls by quantitative PCR (P = 0.011). Thus, the composition of intestinal Bifidobacterium was deeply altered in CHB and HBV cirrhotic patients with a shift from beneficial species to opportunistic pathogens. The results provide further insights into the dysbiosis of the intestinal microbiota in patients with hepatitis B virus-induced chronic liver disease and might potentially serve as guidance for the probiotics interventions of these diseases.
Author Chen, Yunbo
Yang, Fengling
Xu, Min
Wang, Baohong
Fu, Yiqi
Lu, Haifeng
Chen, Yanfei
Li, Lanjuan
Xu, Jiali
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  givenname: Yanfei
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  fullname: Chen, Yanfei
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  givenname: Fengling
  surname: Yang
  fullname: Yang, Fengling
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  givenname: Yunbo
  surname: Chen
  fullname: Chen, Yunbo
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https://www.ncbi.nlm.nih.gov/pubmed/21814872$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright 2012 Springer Science+Business Media, LLC
Springer Science+Business Media, LLC 2011
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Issue 2
Keywords Minimal Hepatic Encephalopathy
Clone Library
Bifidobacterium Species
Bifidobacterium Longum
Bifidobacterium Bifidum
Human
Probiotic
Bifidobacterium
Disease
Eubacteria
Liver
Orthohepadnavirus
Bifidobacteriaceae
Ecology
Virus
Chronic
Hepadnaviridae
Actinobacteridae
Actinobacteria
Bacteria
Bifidobacteriales
Feces
Hepatitis B virus
Language English
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CC BY 4.0
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PublicationTitle Microbial ecology
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Snippet The beneficial effects of Bifidobacteria on health have been widely accepted. Patients with chronic liver disease have varying degrees of intestinal microflora...
The beneficial effects of Bifidobacteria on health have been widely accepted. Patients with chronic liver disease have varying degrees of intestinal microflora...
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StartPage 304
SubjectTerms administration & dosage
Adult
bacteria
Bifidobacterium
Bifidobacterium - classification
Bifidobacterium - genetics
Bifidobacterium - isolation & purification
Bifidobacterium catenulatum
Bifidobacterium dentium
Bifidobacterium longum
Bifidobacterium pseudocatenulatum
Biological and medical sciences
Biomedical and Life Sciences
China
chronic diseases
Chronic hepatitis
chronic hepatitis B
Cirrhosis
classification
clones
Composition
Denaturing Gradient Gel Electrophoresis
DNA, Bacterial
DNA, Bacterial - genetics
Dysbacteriosis
Ecology
Electrophoresis
Feces
Feces - microbiology
Female
Fundamental and applied biological sciences. Psychology
Gel electrophoresis
genetics
Geoecology/Natural Processes
Hepatitis
Hepatitis B
Hepatitis B virus
Hepatitis B virus - physiology
Hepatitis B, Chronic
Hepatitis B, Chronic - microbiology
Hepatitis B, Chronic - virology
HOST MICROBE INTERACTIONS
Humans
Intestinal microflora
intestinal microorganisms
Intestines
Intestines - microbiology
isolation & purification
Libraries
Life Sciences
Liver
Liver Cirrhosis
Liver Cirrhosis - microbiology
Liver Cirrhosis - virology
Liver diseases
Male
Microbial Ecology
Microbial flora
Microbiology
Microbiota
Middle Aged
Molecular Sequence Data
Nature Conservation
Nucleotide sequence
Opportunist infection
pathogens
patients
Phylogeny
physiology
Polymerase Chain Reaction
Probiotics
Probiotics - administration & dosage
Real time
Real-Time Polymerase Chain Reaction
RNA, Ribosomal, 16S
RNA, Ribosomal, 16S - genetics
Sequence Analysis, DNA
Species
Species Specificity
virology
Viruses
Water Quality/Water Pollution
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Title Changes of Fecal Bifidobacterium Species in Adult Patients with Hepatitis B Virus-Induced Chronic Liver Disease
URI https://www.jstor.org/stable/41412418
https://link.springer.com/article/10.1007/s00248-011-9925-5
https://www.ncbi.nlm.nih.gov/pubmed/21814872
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https://www.proquest.com/docview/1420126325
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Volume 63
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