Early postnatal genistein administration permanently affects nitrergic and vasopressinergic systems in a sex-specific way

• Published in: Neuroscience Vol. 346; pp. 203 - 215
• Main Authors: Ponti, G, Rodriguez-Gomez, A, Farinetti, A, Marraudino, M, Filice, F, Foglio, B, Sciacca, G, Panzica, G.C, Gotti, S
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 27.03.2017
• Subjects: Animals; Brain - drug effects; Brain - metabolism; endocrine disruptors; Estradiol - administration & dosage; Female; Genistein - administration & dosage; hypothalamus; limbic system; Male; Mice; Neurology; Nitric Oxide Synthase Type I - metabolism; phytoestrogens; Phytoestrogens - administration & dosage; Sex Characteristics; sexual dimorphism; Vasopressins - metabolism; paraventricular medial magnocellular; Phytoestrogens; anterior parvicellular part of the paraventricular nucleus; EDC; LS; VMHvl; arginin-vasopressin; Limbic system; MPOA; arcuate nucleus; La; E 2; ventral part of the paraventricular nucleus; neuronal isoform of Nitric oxide synthase; basolateral amygdala; PBS; nitric oxide; ERβ; ERα; PaAP; paraventricular dorsal cap; lateral septum; ROI; Bisphenol A; GEN; ARC; BPA; 17-β-estradiol; BLA; ventromedial part of the bed nucleus of the stria terminalis; nNOS; AVP; phosphate saline buffer; Endocrine disruptors; NO; BSTmv; Hypothalamus; PaMP; paraventricular medial parvicellular; genistein; PaMM; Sexual dimorphism; lateral magnocellular part of the paraventricular nucleus; estrogen receptor α; estrogen receptor β; PaV; ventromedial hypothalamus; medial preoptic nucleus; lateral amygdala; endocrine disruptors compound; PaDC; PaLM; region of interest; suprachiasmatic nucleus; SCN; limbic system; E2; endocrine disruptors; phytoestrogens; sexual dimorphism; hypothalamus

Highlights • Postnatal genistein treatment induces permanent neuronal alterations. • Effects of postnatal genistein treatment are sex specific. • GEN affects different intracellular pathways either mimicking E2 or not.