One-step diagnosis of infection and lung cancer using metagenomic sequencing

• Published in: Respiratory research Vol. 26; no. 1; pp. 48 - 14
• Main Authors: Li, Shaoqiang, Zhan, Yangqing, Wang, Yan, Li, Weilong, Wang, Xidong, Wang, Haoru, Sun, Wenjun, Cao, Xuefang, Li, Zhengtu, Ye, Feng
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.02.2025; BioMed Central; BMC
• Subjects: Adult; Aged; Aged, 80 and over; Bronchial lavage fluid; Clinical performance; Diagnosis; DNA sequencing; Female; Genetic aspects; Humans; Infection; Infection diagnosis; Lung cancer; Lung cancer diagnosis; Lung Neoplasms - diagnosis; Lung Neoplasms - genetics; Lung Neoplasms - microbiology; Male; Medical research; Medicine, Experimental; Metagenomics - methods; Middle Aged; Nucleotide sequencing; Onco-mNGS; Physiological aspects; China; Onco-mNGS; Bronchial lavage fluid; Lung cancer diagnosis; Infection diagnosis; Clinical performance

Traditional detection methods face challenges in meeting the diverse clinical needs for diagnosing both lung cancer and infections within a single test. Onco-mNGS has emerged as a promising solution capable of accurately identifying infectious pathogens and tumors simultaneously. However, critical e...