Mortality in children with complicated severe acute malnutrition is related to intestinal and systemic inflammation: an observational cohort study

• Published in: The American journal of clinical nutrition Vol. 104; no. 5; pp. 1441 - 1449
• Main Authors: Attia, Suzanna, Versloot, Christian J, Voskuijl, Wieger, van Vliet, Sara J, Di Giovanni, Valeria, Zhang, Ling, Richardson, Susan, Bourdon, Céline, Netea, Mihai G, Berkley, James A, van Rheenen, Patrick F, Bandsma, Robert HJ
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Nutrition, Inc 01.11.2016; American Society for Nutrition
• Subjects: butyrates; Butyrates - analysis; Campylobacter; Child, Preschool; children; Children & youth; Cohort Studies; cytokines; Cytokines - analysis; death; Diarrhea; Diarrhea - etiology; Diarrhea - mortality; enteropathogens; Fatty Acids, Volatile - analysis; feces; Feces - chemistry; Feces - microbiology; Feces - parasitology; Feces - virology; Female; Giardia; Humans; Infant; Inflammation; International Nutrition; intestines; Intestines - microbiology; Intestines - parasitology; Intestines - virology; least squares; Leukocyte L1 Antigen Complex - analysis; Malawi; Male; Malnutrition; Mortality; Pathogens; Prevalence; propionic acid; Severe Acute Malnutrition - complications; Severe Acute Malnutrition - mortality; Shigella; short chain fatty acids; Malawi; cytokines; severe acute malnutrition; inflammation; diarrhea; inflammatory bowel disease

Diarrhea affects a large proportion of children with severe acute malnutrition (SAM). However, its etiology and clinical consequences remain unclear. We investigated diarrhea, enteropathogens, and systemic and intestinal inflammation for their interrelation and their associations with mortality in c...