Relations between different coping strategies for social stress, tumor development and neuroendocrine and immune activity in male mice

• Published in: Brain, behavior, and immunity Vol. 22; no. 5; pp. 690 - 698
• Main Authors: Azpiroz, A., De Miguel, Z., Fano, E., Vegas, O.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.07.2008
• Subjects: Adaptation, Psychological - physiology; Allergy and Immunology; Animals; Behavior, Animal - physiology; Coping strategies; Corticosterone; Corticosterone - blood; Corticosterone - physiology; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Hypothalamo-Hypophyseal System - immunology; Hypothalamo-Hypophyseal System - physiopathology; Immunity - physiology; Lung Neoplasms - physiopathology; Lung Neoplasms - psychology; Lung Neoplasms - secondary; Male; Melanoma, Experimental - pathology; Melanoma, Experimental - physiopathology; Melanoma, Experimental - psychology; Mice; Neoplasm Metastasis; Neoplasms - pathology; Neoplasms - physiopathology; Neoplasms - psychology; Neurosecretory Systems - immunology; Neurosecretory Systems - physiopathology; NK Cell Lectin-Like Receptor Subfamily K; NK cells; NKG2D; Pituitary-Adrenal System - immunology; Pituitary-Adrenal System - physiopathology; Psychiatry; Receptors, Immunologic - metabolism; Receptors, Immunologic - physiology; Receptors, Natural Killer Cell; Social Behavior; Social stress; Stress, Psychological - immunology; Stress, Psychological - physiopathology; Tumor development; Coping strategies; NK cells; NKG2D; Social stress; Corticosterone; Tumor development

This study analyzes the effects of acute social stress and different coping strategies employed in response to it on the development of B16F10 melanoma pulmonary metastases, the activation of the HPA axis and the NKG2D receptor expression. To this end, male OF1 mice were subjected to 24 h of social...