SYK Is a Critical Regulator of FLT3 in Acute Myeloid Leukemia

• Published in: Cancer cell Vol. 25; no. 2; pp. 226 - 242
• Main Authors: Puissant, Alexandre, Fenouille, Nina, Alexe, Gabriela, Pikman, Yana, Bassil, Christopher F., Mehta, Swapnil, Du, Jinyan, Kazi, Julhash U., Luciano, Frédéric, Rönnstrand, Lars, Kung, Andrew L., Aster, Jon C., Galinsky, Ilene, Stone, Richard M., DeAngelo, Daniel J., Hemann, Michael T., Stegmaier, Kimberly
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.02.2014
• Subjects: Animals; Antimetabolites, Antineoplastic - pharmacology; Apoptosis; Blotting, Western; Cancer and Oncology; Cancer och onkologi; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Clinical Medicine; Drug Resistance, Neoplasm; Fluorouracil - pharmacology; fms-Like Tyrosine Kinase 3 - antagonists & inhibitors; fms-Like Tyrosine Kinase 3 - genetics; fms-Like Tyrosine Kinase 3 - metabolism; Humans; Immunoenzyme Techniques; Intracellular Signaling Peptides and Proteins - antagonists & inhibitors; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Klinisk medicin; Leukemia, Myeloid, Acute - metabolism; Leukemia, Myeloid, Acute - mortality; Leukemia, Myeloid, Acute - pathology; Medical and Health Sciences; Medicin och hälsovetenskap; Mice; Mice, Inbred BALB C; Mutation - genetics; Phosphorylation; Protein Kinase Inhibitors - pharmacology; Protein-Tyrosine Kinases - antagonists & inhibitors; Protein-Tyrosine Kinases - genetics; Protein-Tyrosine Kinases - metabolism; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; Survival Rate; Syk Kinase

Cooperative dependencies between mutant oncoproteins and wild-type proteins are critical in cancer pathogenesis and therapy resistance. Although spleen tyrosine kinase (SYK) has been implicated in hematologic malignancies, it is rarely mutated. We used kinase activity profiling to identify collabora...