Neurotoxicity and persistent cognitive deficits induced by combined MDMA and alcohol exposure in adolescent rats

• Published in: Addiction biology Vol. 15; no. 4; pp. 413 - 423
• Main Authors: Hernandez-Rabaza, Vicente, Navarro-Mora, Graciela, Velazquez-Sanchez, Clara, Ferragud, Antonio, Marin, Maria P., Garcia-Verdugo, Jose M., Renau-Piqueras, Jaime, Canales, Juan J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2010
• Subjects: 3,4‐Methylenedioxymethamphetamine (MDMA); 4-Methylenedioxymethamphetamine (MDMA); adolescence; Age Factors; alcohol; Animals; Cell Differentiation - drug effects; Cell Survival - drug effects; cocaine; Dendrites - drug effects; Dentate Gyrus - drug effects; Dentate Gyrus - pathology; Drug Synergism; Ethanol - toxicity; hippocampus; Male; Maze Learning - drug effects; memory; Mental Recall - drug effects; Microglia - drug effects; N-Methylaspartate - toxicity; Neurogenesis - drug effects; Neurotoxins - toxicity; Orientation - drug effects; Rats; Rats, Long-Evans; Retention (Psychology) - drug effects

ABSTRACT Recent trend assessments of drug consumption reveal an increase in the simultaneous use of several drugs at raves, clubs and college settings among youngsters and young adults. We studied in adolescent rats the effects of repeated exposure to cocaine and 3,4‐methylenedioxymethanphetamine (M...