α-Synuclein in cutaneous autonomic nerves

• Published in: Neurology Vol. 81; no. 18; p. 1604
• Main Authors: Wang, Ningshan, Gibbons, Christopher H, Lafo, Jacob, Freeman, Roy
• Format: Journal Article
• Language: English
• Published: United States 29.10.2013
• Subjects: Aged; alpha-Synuclein - metabolism; Autonomic Pathways - physiopathology; Case-Control Studies; Female; Heart Rate; Humans; Male; Middle Aged; Nerve Fibers - pathology; Nervous System Diseases - etiology; Neurologic Examination; Parkinson Disease - complications; Parkinson Disease - metabolism; Parkinson Disease - pathology; Posture - physiology; Respiration; Skin - innervation; Skin - pathology; Statistics as Topic

To develop a cutaneous biomarker for Parkinson disease (PD). Twenty patients with PD and 14 age- and sex-matched control subjects underwent examinations, autonomic testing, and skin biopsies at the distal leg, distal thigh, and proximal thigh. α-Synuclein deposition and the density of intraepidermal...