Identification of Optimal Mouse Models of Systemic Sclerosis by Interspecies Comparative Genomics

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 68; no. 8; pp. 2003 - 2015
• Main Authors: Sargent, Jennifer L., Li, Zhenghui, Aliprantis, Antonios O., Greenblatt, Matthew, Lemaire, Raphael, Wu, Ming‐hua, Wei, Jun, Taroni, Jaclyn, Harris, Adam, Long, Kristen B., Burgwin, Chelsea, Artlett, Carol M., Blankenhorn, Elizabeth P., Lafyatis, Robert, Varga, John, Clark, Stephen H., Whitfield, Michael L.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.08.2016
• Subjects: Animals; Disease Models, Animal; Female; Gene expression; Genome-Wide Association Study; Genomics; Growth factors; Humans; Male; Mice; Rodents; Scleroderma, Systemic - genetics

Objective Understanding the pathogenesis of systemic sclerosis (SSc) is confounded by considerable disease heterogeneity. Animal models of SSc that recapitulate distinct subsets of disease at the molecular level have not been delineated. We applied interspecies comparative analysis of genomic data f...