miR‐126‐3p Promotes Matrix‐Dependent Perivascular Cell Attachment, Migration and Intercellular Interaction

• Published in: Stem cells (Dayton, Ohio) Vol. 34; no. 5; pp. 1297 - 1309
• Main Authors: Pitzler, Lena, Auler, Markus, Probst, Kristina, Frie, Christian, Bergmeier, Vera, Holzer, Tatjana, Belluoccio, Daniele, van den Bergen, Jocelyn, Etich, Julia, Ehlen, Harald, Zhou, Zhigang, Bielke, Wolfgang, Pöschl, Ernst, Paulsson, Mats, Brachvogel, Bent
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.05.2016
• Subjects: Angiogenesis; Animals; Blood Vessels - cytology; Cell Adhesion - drug effects; Cell Adhesion - genetics; Cell Communication - drug effects; Cell Communication - genetics; Cell Movement - drug effects; Cell Movement - genetics; Cell Shape - drug effects; Chemokines - metabolism; Coculture Techniques; Collagen - pharmacology; Drug Combinations; Extracellular Matrix - drug effects; Extracellular Matrix - metabolism; Extracellular Signal-Regulated MAP Kinases - metabolism; Gene Silencing - drug effects; Human Umbilical Vein Endothelial Cells - cytology; Human Umbilical Vein Endothelial Cells - drug effects; Human Umbilical Vein Endothelial Cells - metabolism; Humans; Laminin - pharmacology; MAP Kinase Signaling System - drug effects; Mice; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; miR‐126‐3p; Neovascularization, Physiologic - genetics; Perivascular cells; Plk2; Proteoglycans - pharmacology; Spred1; Tlr3; Transcriptome - genetics; Up-Regulation - drug effects; Up-Regulation - genetics; Angiogenesis; Perivascular cells; Plk2; miRNA; miR-126-3p; Spred1; Tlr3

microRNAs (miRNAs) can regulate the interplay between perivascular cells (PVC) and endothelial cells (EC) during angiogenesis, but the relevant PVC‐specific miRNAs are not yet defined. Here, we identified miR‐126‐3p and miR‐146a to be exclusively upregulated in PVC upon interaction with EC, determin...