Metaplastic breast carcinoma: A case report and systematic review of the literature
A 78‐year‐old retired woman was diagnosed with metaplastic breast carcinoma (MBC), a rare tumor, in our hospital. We reviewed 15 articles with a total of 1328 patients to determine the epidemiology, clinical features, biomarkers, histology, management and outcome of patients with this tumor. The mea...
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Published in | Pathology international Vol. 61; no. 10; pp. 582 - 588 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Melbourne, Australia
Blackwell Publishing Asia
01.10.2011
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Abstract | A 78‐year‐old retired woman was diagnosed with metaplastic breast carcinoma (MBC), a rare tumor, in our hospital. We reviewed 15 articles with a total of 1328 patients to determine the epidemiology, clinical features, biomarkers, histology, management and outcome of patients with this tumor. The mean age at presentation is 58.5 years (range 32–83). Eighty‐one percent of patients presented either with a breast mass or abnormal mammographic finding. Twenty‐three percent of patients had a family history of breast cancer. Estrogen receptors were only found in 12%, progesterone receptors in 10% and HER2 in 6% of patients. The main method of treatment was mastectomy (66.9%) in combination with chemotherapy (57%) and radiotherapy (47%). Five‐year disease‐free survival ranged between 40% and 84% and 5‐year overall survival ranged between 64 and 83%. We have further reviewed the nature of this disease in the light of advancement in genetics, such as microarray gene expression profiling. The relationship of MBC with triple‐negative tumor and basal‐like tumor is discussed. It is hoped that advances in genetics and biomarkers will bring forward the era of personalized medicine in the treatment of breast carcinoma. |
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AbstractList | A 78-year-old retired woman was diagnosed with metaplastic breast carcinoma (MBC), a rare tumor, in our hospital. We reviewed 15 articles with a total of 1328 patients to determine the epidemiology, clinical features, biomarkers, histology, management and outcome of patients with this tumor. The mean age at presentation is 58.5 years (range 32-83). Eighty-one percent of patients presented either with a breast mass or abnormal mammographic finding. Twenty-three percent of patients had a family history of breast cancer. Estrogen receptors were only found in 12%, progesterone receptors in 10% and HER2 in 6% of patients. The main method of treatment was mastectomy (66.9%) in combination with chemotherapy (57%) and radiotherapy (47%). Five-year disease-free survival ranged between 40% and 84% and 5-year overall survival ranged between 64 and 83%. We have further reviewed the nature of this disease in the light of advancement in genetics, such as microarray gene expression profiling. The relationship of MBC with triple-negative tumor and basal-like tumor is discussed. It is hoped that advances in genetics and biomarkers will bring forward the era of personalized medicine in the treatment of breast carcinoma. |
Author | Bullen, Caroline Ellenbogen, Simon Dalal, Neha Toumi, Zaher Tang, Albert C. S. |
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Cites_doi | 10.1016/j.ijrobp.2005.08.024 10.1097/00000658-199911000-00010 10.1002/(SICI)1097-0339(199604)14:3<226::AID-DC6>3.0.CO;2-F 10.3390/cancers2021040 10.1186/bcr1636 10.1016/S0929-6441(09)60049-7 10.1093/jjco/hyp139 10.1200/jco.2004.22.90140.844 10.1056/NEJMoa052258 10.1200/JCO.2007.13.1748 10.1093/annonc/mdl006 10.1016/j.amjsurg.2006.01.038 10.1007/s10549-004-7260-y 10.1186/1757-1626-2-15 10.1080/02841860500513235 10.1158/1078-0432.CCR-08-1211 10.1111/j.1440-1673.2004.01305.x 10.1186/1477-7819-6-60 10.1007/s10549-006-9301-1 10.1002/dc.2056 10.1158/1078-0432.CCR-08-1208 10.1136/jcp.2005.030536 10.1002/(SICI)1096-9098(199908)71:4<220::AID-JSO3>3.0.CO;2-L 10.1023/A:1008329910362 10.1245/s10434-006-9124-7 |
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Snippet | A 78‐year‐old retired woman was diagnosed with metaplastic breast carcinoma (MBC), a rare tumor, in our hospital. We reviewed 15 articles with a total of 1328... A 78-year-old retired woman was diagnosed with metaplastic breast carcinoma (MBC), a rare tumor, in our hospital. We reviewed 15 articles with a total of 1328... |
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SubjectTerms | Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers, Tumor - metabolism breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - pathology Breast Neoplasms - surgery case report Female Humans matrix producing breast cancer Metaplasia metaplastic breast cancer Mixed Tumor, Malignant - drug therapy Mixed Tumor, Malignant - pathology Mixed Tumor, Malignant - surgery Nitriles - therapeutic use Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism systematic review Triazoles - therapeutic use |
Title | Metaplastic breast carcinoma: A case report and systematic review of the literature |
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