Ursodeoxycholic acid therapy in cystic fibrosis liver disease - a retrospective long-term follow-up case-control study

• Published in: Alimentary pharmacology & therapeutics Vol. 36; no. 3; pp. 266 - 273
• Main Authors: Kappler, M., Espach, C., Schweiger-Kabesch, A., Lang, T., Hartl, D., Hector, A., Glasmacher, C., Griese, M.
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell Publishing Ltd 01.08.2012; Blackwell
• Subjects: Adolescent; Adult; Biological and medical sciences; Case-Control Studies; Chemical and Drug Induced Liver Injury - etiology; Child; Child, Preschool; Cholagogues and Choleretics - adverse effects; Cholagogues and Choleretics - therapeutic use; Cystic Fibrosis - complications; Cystic Fibrosis - drug therapy; Digestive system; Errors of metabolism; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Infant; Liver Function Tests; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Longitudinal Studies; Male; Medical sciences; Metabolic diseases; Miscellaneous hereditary metabolic disorders; Other diseases. Semiology; Pharmacology. Drug treatments; Retrospective Studies; Ursodeoxycholic Acid - adverse effects; Ursodeoxycholic Acid - therapeutic use; Young Adult; Hepatic fibrosis; Human; Respiratory disease; Metabolic diseases; Hepatic disease; Cystic fibrosis; Case control study; Long term; Retrospective; Genetic disease; Ursodeoxycholic acid; Treatment; Follow up study; Bile acid; Digestive diseases; Pancreatic disease

Summary Background The prevention and treatment of liver disease associated with cystic fibrosis remain a significant unresolved problem. Aim To assess the long‐term effects of continuous ursodeoxycholic acid (UDCA) therapy in cystic fibrosis patients with constantly elevated serum liver enzymes. Me...