Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats

• Published in: The European journal of neuroscience Vol. 31; no. 4; pp. 722 - 732
• Main Authors: Liu, Ming C., Akinyi, Linnet, Scharf, Dancia, Mo, Jixiang, Larner, Stephen F., Muller, Uwe, Oli, Monika W., Zheng, Wenrong, Kobeissy, Firas, Papa, Linda, Lu, Xi-Chun, Dave, Jitendra R., Tortella, Frank C., Hayes, Ronald L., Wang, Kevin K. W.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2010
• Subjects: Animals; biomarker; Biomarkers - blood; Biomarkers - cerebrospinal fluid; Brain - metabolism; Brain Injuries - blood; Brain Injuries - cerebrospinal fluid; cell death; diagnosis; Disease Models, Animal; Infarction, Middle Cerebral Artery - blood; Infarction, Middle Cerebral Artery - cerebrospinal fluid; ischemia; Male; Rats; Rats, Sprague-Dawley; Spectrin - cerebrospinal fluid; stroke; traumatic brain injury; Ubiquitin Thiolesterase - blood; Ubiquitin Thiolesterase - cerebrospinal fluid

Ubiquitin C‐terminal hydrolase‐L1 (UCH‐L1), also called neuronal‐specific protein gene product 9.5, is a highly abundant protein in the neuronal cell body and has been identified as a possible biomarker on the basis of a recent proteomic study. In this study, we examined whether UCH‐L1 was significa...