Novel Function of Serine Protease HTRA1 in Inhibiting Adipogenic Differentiation of Human Mesenchymal Stem Cells via MAP Kinase‐Mediated MMP Upregulation

• Published in: Stem cells (Dayton, Ohio) Vol. 34; no. 6; pp. 1601 - 1614
• Main Authors: Tiaden, André N., Bahrenberg, Gregor, Mirsaidi, Ali, Glanz, Stephan, Blüher, Matthias, Richards, Peter J.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.06.2016
• Subjects: Adipocytes; Adipogenesis; Adipose tissue; Adult stem cells; Cell signaling; Diabetes; Differentiation; Enzyme Activation; Extracellular Matrix - metabolism; Heparan Sulfate Proteoglycans - metabolism; High temperature; High-Temperature Requirement A Serine Peptidase 1 - metabolism; HTRA1; Humans; Intra-Abdominal Fat - pathology; JNK Mitogen-Activated Protein Kinases - metabolism; Lipid Droplets - metabolism; Matrix Metalloproteinases - metabolism; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - enzymology; MMP; Mode of action; Obesity - pathology; Stem cells; Up-Regulation; MMP; Adult stem cells; HTRA1; Diabetes; Differentiation; Cell signaling; Adipogenesis

Adipogenesis is the process by which mesenchymal stem cells (MSCs) develop into lipid‐laden adipocytes. Being the dominant cell type within adipose tissue, adipocytes play a central role in regulating circulating fatty acid levels, which is considered to be of critical importance in maintaining insu...