Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development

• Published in: Hepatology (Baltimore, Md.) Vol. 56; no. 6; pp. 2255 - 2267
• Main Authors: Wu, Kun, Ding, Jin, Chen, Cheng, Sun, Wen, Ning, Bei-Fang, Wen, Wen, Huang, Lei, Han, Tao, Yang, Wen, Wang, Chao, Li, Zhong, Wu, Meng-Chao, Feng, Gen-Sheng, Xie, Wei-Fen, Wang, Hong-Yang
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.12.2012; Wiley; Wolters Kluwer Health, Inc
• Subjects: AC133 Antigen; Animals; Antigens, CD - metabolism; Antigens, Differentiation - metabolism; Antigens, Neoplasm - metabolism; Biological and medical sciences; Biomarkers, Tumor - metabolism; Cell Adhesion Molecules - metabolism; Cell Transformation, Neoplastic - metabolism; Cell Transformation, Neoplastic - pathology; Diethylnitrosamine; Epithelial Cell Adhesion Molecule; Gastroenterology. Liver. Pancreas. Abdomen; Glycoproteins - metabolism; Hepatology; Humans; Liver - metabolism; Liver cancer; Liver cirrhosis; Liver Cirrhosis - metabolism; Liver Cirrhosis - pathology; Liver Neoplasms, Experimental - chemically induced; Liver Neoplasms, Experimental - metabolism; Liver Neoplasms, Experimental - pathology; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, SCID; MicroRNAs - metabolism; Neoplastic Stem Cells - metabolism; Peptides - metabolism; Pluripotent Stem Cells - drug effects; Pluripotent Stem Cells - metabolism; Pluripotent Stem Cells - pathology; Proteins; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; PTEN Phosphohydrolase - metabolism; Rats; Rats, Wistar; STAT3 Transcription Factor - metabolism; Thy-1 Antigens - metabolism; TOR Serine-Threonine Kinases - metabolism; Transforming Growth Factor beta - metabolism; Transforming Growth Factor beta - pharmacology; Tumors; Liver cancer; Transforming growth factor; Liver; Gastroenterology; Digestive diseases; Hepatic disease; Malignant tumor; Tumor cell; Cancer
• ISSN: 0270-9139; 1527-3350; 1527-3350
• DOI: 10.1002/hep.26007

Liver cirrhosis is a predominant risk factor for hepatocellular carcinoma (HCC). However, the mechanism underlying the progression from cirrhosis to HCC remains unclear. Herein we report the concurrent increase of liver progenitor cells (LPCs) and transforming growth factor‐β (TGF‐β) in diethylnitro...