Prognostic value of tissue‐based biomarker signature in clear cell renal cell carcinoma

• Published in: BJU international Vol. 119; no. 5; pp. 741 - 747
• Main Authors: Haddad, Ahmed Q., Luo, Jun‐Hang, Krabbe, Laura‐Maria, Darwish, Oussama, Gayed, Bishoy, Youssef, Ramy, Kapur, Payal, Rakheja, Dinesh, Lotan, Yair, Sagalowsky, Arthur, Margulis, Vitaly
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.05.2017
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; biomarkers; Biomarkers, Tumor - analysis; Carcinoma, Renal Cell - chemistry; Carcinoma, Renal Cell - diagnosis; Carcinoma, Renal Cell - secondary; Carcinoma, Renal Cell - surgery; cell cycle; epithelial mesenchymal transition; Female; Humans; Kidney Neoplasms - chemistry; Kidney Neoplasms - diagnosis; Kidney Neoplasms - pathology; Kidney Neoplasms - surgery; Male; mammalian target of rapamycin; Middle Aged; Multivariate analysis; Neoplasm Recurrence, Local - diagnosis; Neoplasm Recurrence, Local - epidemiology; Nephrectomy; Prognosis; renal cell carcinoma; Retrospective Studies; Risk Assessment; Young Adult; epithelial mesenchymal transition; mammalian target of rapamycin; renal cell carcinoma; cell cycle; prognosis; biomarkers

Objective To improve risk stratification for recurrence prognostication in patients with localised clear cell renal cell carcinoma (ccRCC). Patients and Methods In all, 367 patients with non‐metastatic ccRCC were included. The cohort was divided into a training and validation set. Using tissue micro...