The role of Wnt, ARL4C, and Sema3A in developmental process and disease pathogenesis

Various types of tumors, including malignant and benign ones, occur in the oral cavity. These arise from the mucosal epithelium, odontogenic epithelium, and salivary gland. To date, few major driver events in oral tumors have been identified. Accordingly, molecular targets in anti‐tumor therapy for...

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Published inPathology international Vol. 73; no. 6; pp. 217 - 233
Main Authors Fujii, Shinsuke, Kiyoshima, Tamotsu
Format Journal Article
LanguageEnglish
Published Australia Wiley Subscription Services, Inc 01.06.2023
Subjects
ACC
Adenoid
Ameloblastoma
ARL4C
Catenin
developmental process
Epithelium
Homeostasis
Oral carcinoma
Oral cavity
Oral squamous cell carcinoma
OSCC
Pathogenesis
Phosphates
Ribosylation
Salivary gland
Salivary glands
Sema3A
Semaphorins
Signal transduction
tumor formation
Tumors
Wnt
Wnt protein
ARL4C
Sema3A
ACC
OSCC
developmental process
ameloblastoma
tumor formation
Wnt
Online AccessGet full text
ISSN1320-5463
1440-1827
1440-1827
DOI10.1111/pin.13325

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Abstract Various types of tumors, including malignant and benign ones, occur in the oral cavity. These arise from the mucosal epithelium, odontogenic epithelium, and salivary gland. To date, few major driver events in oral tumors have been identified. Accordingly, molecular targets in anti‐tumor therapy for oral tumors are lacking. We focused on elucidating the function of aberrantly activated signal transduction related to oral tumor formation, especially in oral squamous cell carcinoma, ameloblastoma, and adenoid cystic carcinoma, which are raised as common oral tumors. Wnt/β‐catenin‐dependent pathway is involved in the developmental process, organ homeostasis and disease pathogenesis through regulating various cellular functions by enhancing transcriptional activity. Recently, we identified ADP‐ribosylation factor (ARF)‐like 4c (ARL4C) and Semaphorin 3A (Sema3A), the expression of which is regulated by Wnt/β‐catenin‐dependent pathway, and characterized their functions in the developmental process and tumor formation. This review highlights the recent advances in understanding the roles of Wnt/β‐catenin‐dependent pathway, ARL4C and Sema3A, as determined by pathological and experimental studies.
AbstractList Various types of tumors, including malignant and benign ones, occur in the oral cavity. These arise from the mucosal epithelium, odontogenic epithelium, and salivary gland. To date, few major driver events in oral tumors have been identified. Accordingly, molecular targets in anti-tumor therapy for oral tumors are lacking. We focused on elucidating the function of aberrantly activated signal transduction related to oral tumor formation, especially in oral squamous cell carcinoma, ameloblastoma, and adenoid cystic carcinoma, which are raised as common oral tumors. Wnt/β-catenin-dependent pathway is involved in the developmental process, organ homeostasis and disease pathogenesis through regulating various cellular functions by enhancing transcriptional activity. Recently, we identified ADP-ribosylation factor (ARF)-like 4c (ARL4C) and Semaphorin 3A (Sema3A), the expression of which is regulated by Wnt/β-catenin-dependent pathway, and characterized their functions in the developmental process and tumor formation. This review highlights the recent advances in understanding the roles of Wnt/β-catenin-dependent pathway, ARL4C and Sema3A, as determined by pathological and experimental studies.
Various types of tumors, including malignant and benign ones, occur in the oral cavity. These arise from the mucosal epithelium, odontogenic epithelium, and salivary gland. To date, few major driver events in oral tumors have been identified. Accordingly, molecular targets in anti-tumor therapy for oral tumors are lacking. We focused on elucidating the function of aberrantly activated signal transduction related to oral tumor formation, especially in oral squamous cell carcinoma, ameloblastoma, and adenoid cystic carcinoma, which are raised as common oral tumors. Wnt/β-catenin-dependent pathway is involved in the developmental process, organ homeostasis and disease pathogenesis through regulating various cellular functions by enhancing transcriptional activity. Recently, we identified ADP-ribosylation factor (ARF)-like 4c (ARL4C) and Semaphorin 3A (Sema3A), the expression of which is regulated by Wnt/β-catenin-dependent pathway, and characterized their functions in the developmental process and tumor formation. This review highlights the recent advances in understanding the roles of Wnt/β-catenin-dependent pathway, ARL4C and Sema3A, as determined by pathological and experimental studies.Various types of tumors, including malignant and benign ones, occur in the oral cavity. These arise from the mucosal epithelium, odontogenic epithelium, and salivary gland. To date, few major driver events in oral tumors have been identified. Accordingly, molecular targets in anti-tumor therapy for oral tumors are lacking. We focused on elucidating the function of aberrantly activated signal transduction related to oral tumor formation, especially in oral squamous cell carcinoma, ameloblastoma, and adenoid cystic carcinoma, which are raised as common oral tumors. Wnt/β-catenin-dependent pathway is involved in the developmental process, organ homeostasis and disease pathogenesis through regulating various cellular functions by enhancing transcriptional activity. Recently, we identified ADP-ribosylation factor (ARF)-like 4c (ARL4C) and Semaphorin 3A (Sema3A), the expression of which is regulated by Wnt/β-catenin-dependent pathway, and characterized their functions in the developmental process and tumor formation. This review highlights the recent advances in understanding the roles of Wnt/β-catenin-dependent pathway, ARL4C and Sema3A, as determined by pathological and experimental studies.
Author Kiyoshima, Tamotsu
Fujii, Shinsuke
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Cites_doi 10.1002/path.5189
10.1038/26785
10.1046/j.1365-2133.2003.05640.x
10.1093/jb/mvw069
10.1242/jcs.235556
10.1038/nature09367
10.1038/ng.2643
10.1126/science.1848370
10.1016/0092-8674(93)80064-L
10.1155/2016/3679545
10.1002/dvdy.24627
10.1038/nature13863
10.1242/dev.015495
10.1111/j.1600-0714.2011.01104.x
10.3892/or.2017.5616
10.1016/j.prp.2017.12.016
10.1111/j.1469-7580.2008.01014.x
10.1016/j.jpedsurg.2013.09.033
10.1016/j.celrep.2012.08.018
10.1186/s40360-017-0163-4
10.1053/j.gastro.2014.09.042
10.1016/j.mcn.2013.08.003
10.1016/j.brainres.2018.12.041
10.1038/onc.2014.402
10.1158/1078-0432.CCR-17-0790
10.1111/j.1601-0825.2006.01293.x
10.1371/journal.pbio.1001808
10.1523/JNEUROSCI.2521-09.2009
10.1242/jcs.00123
10.1242/dev.141325
10.1016/j.celrep.2014.09.027
10.1016/j.mcn.2013.04.009
10.1101/cshperspect.a008425
10.1111/cas.14303
10.1016/j.ydbio.2011.07.023
10.1016/S1534-5807(02)00167-3
10.1016/j.oraloncology.2004.04.011
10.1038/nature01658
10.18632/oncotarget.10104
10.1242/dev.134486
10.1080/19336918.2016.1243644
10.1016/j.tcb.2004.10.004
10.1073/pnas.1114802109
10.1016/j.bbrc.2022.09.012
10.1038/nature06196
10.1038/ncb3000
10.1038/onc.2009.204
10.1016/j.febslet.2004.04.048
10.1242/dev.00172
10.1186/s12885-020-07694-4
10.1016/S0733-8635(18)30106-2
10.1016/j.devcel.2015.01.023
10.1002/stem.1338
10.1038/nature01593
10.1038/sj.onc.1209824
10.1016/S0959-4388(03)00003-5
10.1038/nrm3117
10.1093/emboj/17.5.1371
10.1038/nature15695
10.1016/j.prp.2022.153909
10.1038/418934a
10.1016/S0962-8924(99)01668-2
10.1242/dev.129.20.4831
10.1126/science.275.5307.1784
10.1126/science.272.5264.1023
10.7554/eLife.66721
10.1016/j.prp.2022.153991
10.1038/nature14129
10.1074/jbc.M305892200
10.1016/j.oraloncology.2012.05.011
10.1242/dev.145045
10.1002/dvdy.10472
10.1016/j.celrep.2017.01.066
10.1007/s00432-005-0027-y
10.1073/pnas.1201583109
10.1038/s41563-020-0754-0
10.1002/path.4096
10.1002/path.4317
10.1016/B978-0-12-386035-4.00002-1
10.3233/CBM-181836
10.1038/nature07935
10.1016/j.stemcr.2015.11.009
10.1111/pin.12899
10.1038/ncb2719
10.1111/j.1600-0714.2008.00645.x
10.1016/j.humpath.2004.12.009
10.1080/19336918.2016.1212805
10.1038/nm1570
10.1016/S0092-8674(00)81333-1
10.1242/jcs.02958
10.1016/j.tcb.2009.01.003
10.1016/j.cell.2018.07.027
10.1126/science.1145720
10.1038/nature11826
10.1002/path.5814
10.18632/oncotarget.6831
10.1126/science.1651563
10.1158/1078-0432.CCR-14-1069
10.1038/ncb3047
10.1093/carcin/bgy106
10.1016/j.cell.2014.11.050
10.1038/modpathol.3800209
10.1002/embj.201386942
10.1016/j.devcel.2009.06.005
10.1038/nm.2695
10.1016/j.ydbio.2004.09.023
10.1016/j.stem.2009.11.013
10.1016/j.stemcr.2014.09.015
10.1002/(SICI)1097-4695(199709)33:3<316::AID-NEU9>3.0.CO;2-4
10.1038/ng.2986
10.1006/mcne.1999.0777
10.1038/ncomms9989
10.1038/s41598-019-39686-1
10.1074/jbc.M002470200
10.1038/382638a0
10.1093/embo-reports/kvf221
10.1002/cncr.27408
10.1242/dev.126.20.4557
10.1016/j.cell.2017.05.016
10.2147/OTT.S282992
10.1016/j.cub.2007.03.007
10.1371/journal.pone.0023139
10.1016/j.oraloncology.2008.06.002
10.1016/S0901-5027(05)80641-1
10.1073/pnas.0607289103
10.1245/s10434-017-6292-6
10.1111/jcmm.16366
10.1242/dev.121.4.1015
10.1016/0092-8674(93)90625-Z
10.1038/sj.onc.1210348
10.1038/ng.239
10.1016/j.stem.2016.04.003
10.1016/j.gde.2006.12.007
10.1016/j.bbrc.2009.04.125
10.1038/nsmb1247
10.1126/science.1134389
10.1523/JNEUROSCI.23-17-06671.2003
10.1016/j.stem.2017.12.009
10.18632/oncotarget.13147
10.1016/j.cell.2014.12.021
10.1038/nature01611
10.1038/19539
10.1016/j.molcel.2005.10.022
10.1038/emboj.2013.204
10.1242/dev.033803
10.1073/pnas.1202774109
10.1016/j.cell.2014.08.017
10.1038/s41586-022-05043-y
10.7150/ijms.10501
10.2337/diabetes.52.3.588
10.1158/1535-7163.MCT-18-0824
10.1073/pnas.1017063108
10.1073/pnas.1409064111
10.1016/S0014-5793(99)00759-0
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Keywords ARL4C
Sema3A
ACC
OSCC
developmental process
ameloblastoma
tumor formation
Wnt
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References 2011; 358
2004; 566
2015; 148
2020; 20
1993; 22
1997; 275
2010; 467
1996; 382
2008; 37
2016; 143
2019; 18
2012; 18
2016; 2016
2003; 278
2003; 52
1998; 395
2014; 20
2018; 174
1998; 17
2018; 39
2013; 57
2013; 56
2019; 24
2018; 214
2014; 16
2017; 161
2022; 608
2009; 19
1995; 121
1999; 456
2017; 169
2014; 12
2014; 11
2010; 6
2009; 17
2007; 17
2019; 9
2007; 449
2004; 40
2006; 119
2014; 49
2016; 10
2002; 2
2002; 3
2014; 46
2002; 418
2015; 526
2009; 459
2016; 18
2018; 22
2011; 6
2007; 13
2012; 228
2022; 236
2007; 14
2009; 214
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2022; 630
2018; 25
2022; 235
2016; 6
2016; 7
1997; 33
2002; 129
2008; 135
2012; 48
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2008; 40
2007; 318
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2012; 41
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Dutra SN (e_1_2_16_89_1) 2017; 9
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Isono T (e_1_2_16_112_1) 2019; 9
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Zhang P (e_1_2_16_122_1) 2022; 2022
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Takata T (e_1_2_16_2_1) 2017
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e_1_2_16_16_1
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Tang C (e_1_2_16_161_1) 2014; 7
e_1_2_16_31_1
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Vered M (e_1_2_16_4_1) 2017
Yeh KT (e_1_2_16_85_1) 2003; 23
References_xml – volume: 459
  start-page: 262
  year: 2009
  end-page: 5
  article-title: Single Lgr5 stem cells build crypt‐villus structures in vitro without a mesenchymal niche
  publication-title: Nature
– volume: 18
  start-page: 1917
  year: 2017
  end-page: 29
  article-title: Clonal expansion of Lgr5‐positive cells from mammalian cochlea and high‐purity generation of sensory hair cells
  publication-title: Cell Rep
– volume: 26
  start-page: 774
  year: 2007
  end-page: 80
  article-title: Differential effects of inactivated Axin1 and activated β‐catenin mutations in human hepatocellular carcinomas
  publication-title: Oncogene
– volume: 7
  start-page: 6048
  year: 2016
  end-page: 62
  article-title: Axon guidance molecule semaphorin3A is a novel tumor suppressor in head and neck squamous cell carcinoma
  publication-title: Oncotarget
– volume: 108
  start-page: 1937
  year: 2011
  end-page: 42
  article-title: Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down‐regulating β‐catenin
  publication-title: Proc Nat Acad Sci
– volume: 7
  start-page: 4782
  year: 2014
  end-page: 94
  article-title: Decreased expression of SEMA3A is associated with poor prognosis in gastric carcinoma
  publication-title: Int J Clin Exp Pathol
– volume: 251
  start-page: 1366
  year: 1991
  end-page: 70
  article-title: Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers
  publication-title: Science
– volume: 17
  start-page: 45
  year: 2007
  end-page: 51
  article-title: The many ways of Wnt in cancer
  publication-title: Curr Opin Genet Dev
– volume: 12
  start-page: 362
  year: 2011
  end-page: 75
  article-title: ARF family G proteins and their regulators: roles in membrane transport, development and disease
  publication-title: Nat Rev Mol Cell Biol
– volume: 214
  start-page: 502
  year: 2009
  end-page: 15
  article-title: Current knowledge of tooth development: patterning and mineralization of the murine dentition
  publication-title: J Anat
– volume: 39
  start-page: 1283
  year: 2018
  end-page: 91
  article-title: Semaphorin‐3A inhibits multiple myeloma progression in a mouse model
  publication-title: Carcinogenesis
– volume: 11
  start-page: 1282
  year: 2014
  end-page: 97
  article-title: Odontomas and supernumerary teeth: is there a common origin?
  publication-title: Int J Med Sci
– volume: 384
  start-page: 352
  year: 2009
  end-page: 6
  article-title: ADP‐ribosylation factor like 7 (ARL7) interacts with α‐tubulin and modulates intracellular vesicular transport
  publication-title: Biochem Biophys Res Commun
– volume: 23
  start-page: 6671
  year: 2003
  end-page: 80
  article-title: Semaphorin 3F is critical for development of limbic system circuitry and is required in neurons for selective CNS axon guidance events
  publication-title: J Neurosci
– volume: 52
  start-page: 588
  year: 2003
  end-page: 95
  article-title: Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo
  publication-title: Diabetes
– volume: 32
  start-page: 667
  year: 2015
  end-page: 77
  article-title: Submandibular parasympathetic gangliogenesis requires sprouty‐dependent Wnt signals from epithelial progenitors
  publication-title: Dev Cell
– volume: 161
  start-page: 27
  year: 2017
  end-page: 35
  article-title: Arl4c is a key regulator of tubulogenesis and tumourigenesis as a target gene of Wnt‐β‐catenin and growth factor‐Ras signalling
  publication-title: J Biochem
– volume: 13
  start-page: 79
  year: 2003
  end-page: 89
  article-title: Semaphorin junction: making tracks toward neural connectivity
  publication-title: Curr Opin Neurobiol
– volume: 118
  start-page: 4444
  year: 2012
  end-page: 51
  article-title: Adenoid cystic carcinoma of the head and neck: incidence and survival trends based on 1973‐2007 surveillance, epidemiology, and end results data
  publication-title: Cancer
– volume: 40
  start-page: 932
  year: 2004
  end-page: 40
  article-title: Expression of adenomatous polyposis coli (APC) in tumorigenesis of human oral squamous cell carcinoma
  publication-title: Oral Oncol
– volume: 18
  start-page: 602
  year: 2019
  end-page: 12
  article-title: Chemically modified antisense oligonucleotide against ARL4C inhibits primary and metastatic liver tumor growth
  publication-title: Mol Cancer Ther
– volume: 18
  start-page: 827
  year: 2016
  end-page: 38
  article-title: A Colorectal tumor organoid library demonstrates progressive loss of niche factor requirements during tumorigenesis
  publication-title: Cell Stem Cell
– volume: 17
  start-page: 711
  year: 2007
  end-page: 6
  article-title: The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane
  publication-title: Curr Biol
– volume: 14
  start-page: 2541
  year: 2021
  end-page: 53
  article-title: MicroRNA‐302s might regulate ARL4C‐mediated gastric cancer progression via p53 signaling: bioinformatics analysis and experiments validation
  publication-title: Onco Targets Ther
– volume: 608
  start-page: 784
  year: 2022
  end-page: 94
  article-title: Cell‐matrix interface regulates dormancy in human colon cancer stem cells
  publication-title: Nature
– volume: 247
  start-page: 266
  year: 2019
  end-page: 78
  article-title: ARL4C stabilized by AKT/mTOR pathway promotes the invasion of PTEN‐deficient primary human glioblastoma
  publication-title: J Pathol
– volume: 275
  start-page: 1784
  year: 1997
  end-page: 7
  article-title: Constitutive transcriptional activation by a β‐Catenin‐Tcf complex in APC−/−colon carcinoma
  publication-title: Science
– volume: 119
  start-page: 1494
  year: 2006
  end-page: 503
  article-title: An N‐terminally acetylated Arf‐like GTPase is localised to lysosomes and affects their motility
  publication-title: J Cell Sci
– volume: 14
  start-page: 484
  year: 2007
  end-page: 92
  article-title: The DIX domain of dishevelled confers Wnt signaling by dynamic polymerization
  publication-title: Nat Struct Mol Biol
– volume: 135
  start-page: 1625
  year: 2008
  end-page: 34
  article-title: Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme
  publication-title: Development
– volume: 2022
  start-page: 1
  year: 2022
  end-page: 24
  article-title: ARL4C regulates the progression of clear cell renal cell carcinoma by affecting the Wnt/β‐Catenin signaling pathway
  publication-title: J Oncol
– volume: 148
  start-page: 126
  year: 2015
  end-page: 36
  article-title: In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection
  publication-title: Gastroenterology
– volume: 10
  start-page: 593
  year: 2016
  end-page: 603
  article-title: Contribution of semaphorins to the formation of the peripheral nervous system in higher vertebrates
  publication-title: Cell Adh Migr
– volume: 13
  start-page: 360
  year: 2007
  end-page: 5
  article-title: Oral and maxillofacial manifestations of familial adenomatous polyposis
  publication-title: Oral Dis
– volume: 159
  start-page: 163
  year: 2014
  end-page: 75
  article-title: Identification of multipotent luminal progenitor cells in human prostate organoid cultures
  publication-title: Cell
– volume: 456
  start-page: 384
  year: 1999
  end-page: 8
  article-title: ADP‐ribosylation factor (ARF)‐like 4, 6, and 7 represent a subgroup of the ARF family characterized by rapid nucleotide exchange and a nuclear localization signal
  publication-title: FEBS Lett
– volume: 25
  start-page: 745
  year: 2018
  end-page: 53
  article-title: Identification of ARL4C as a peritoneal dissemination‐associated gene and its clinical significance in gastric cancer
  publication-title: Ann Surg Oncol
– volume: 2
  start-page: 643
  year: 2002
  end-page: 53
  article-title: WNT signals are required for the initiation of hair follicle development
  publication-title: Dev Cell
– volume: 22
  start-page: 226
  year: 1993
  end-page: 30
  article-title: Natural course of jaw lesions in patients with familial adenomatosis coli (Gardner's syndrome)
  publication-title: Int J Oral Maxillofac Surg
– volume: 232
  start-page: 492
  year: 2014
  end-page: 8
  article-title: High frequency of BRAF V600E mutations in ameloblastoma
  publication-title: J Pathol
– volume: 103
  start-page: 18627
  year: 2006
  end-page: 32
  article-title: Continuous tooth generation in mouse is induced by activated epithelial Wnt/β‐catenin signaling
  publication-title: Proc Nat Acad Sci
– volume: 526
  start-page: 564
  year: 2015
  end-page: 8
  article-title: Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis
  publication-title: Nature
– volume: 45
  start-page: 309
  year: 2009
  end-page: 16
  article-title: Global epidemiology of oral and oropharyngeal cancer
  publication-title: Oral Oncol
– volume: 16
  start-page: 951
  issue: 951‐61
  year: 2014
  end-page: 61
  article-title: Single luminal epithelial progenitors can generate prostate organoids in culture
  publication-title: Nature Cell Biol
– volume: 33
  start-page: 702
  year: 2014
  end-page: 18
  article-title: A combination of Wnt and growth factor signaling induces Arl4c expression to form epithelial tubular structures
  publication-title: EMBO J
– volume: 6
  start-page: 150
  year: 2016
  end-page: 62
  article-title: Long‐term in vitro expansion of salivary gland stem cells driven by Wnt signals
  publication-title: Stem Cell Reports
– volume: 129
  start-page: 5767
  year: 2002
  end-page: 78
  article-title: Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP‐ and FGF‐dependent mechanisms
  publication-title: Development
– volume: 7
  start-page: 1383
  year: 1996
  end-page: 92
  article-title: Complex regulation of human c‐kit transcription by promoter repressors, activators, and specific myb elements
  publication-title: Cell Growth Differ
– volume: 143
  start-page: 2311
  year: 2016
  end-page: 24
  article-title: The WNT/MYB pathway suppresses KIT expression to control the timing of salivary proacinar differentiation and duct formation
  publication-title: Development
– volume: 16
  start-page: 745
  year: 2014
  end-page: 57
  article-title: Lgr5 marks stem/progenitor cells in ovary and tubal epithelia
  publication-title: Nature Cell Biol
– volume: 423
  start-page: 409
  year: 2003
  end-page: 14
  article-title: A role for Wnt signalling in self‐renewal of haematopoietic stem cells
  publication-title: Nature
– volume: 109
  start-page: 15348
  year: 2012
  end-page: 53
  article-title: Wnt ligands signal in a cooperative manner to promote foregut organogenesis
  publication-title: Proc Nat Acad Sci
– volume: 126
  start-page: 4557
  year: 1999
  end-page: 68
  article-title: Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation
  publication-title: Development
– volume: 121
  start-page: 1015
  year: 1995
  end-page: 22
  article-title: Branching morphogenesis of embryonic mouse lung epithelium in mesenchyme‐free culture
  publication-title: Development
– volume: 494
  start-page: 247
  year: 2013
  end-page: 50
  article-title: In vitro expansion of single Lgr5+ liver stem cells induced by Wnt‐driven regeneration
  publication-title: Nature
– volume: 275
  start-page: 37815
  year: 2000
  end-page: 23
  article-title: ARL4, an ARF‐like protein that is developmentally regulated and localized to nuclei and nucleoli
  publication-title: J Biol Chem
– volume: 2016
  start-page: 1
  year: 2016
  end-page: 14
  article-title: The chemorepulsive protein semaphorin 3A and perineuronal net‐mediated plasticity
  publication-title: Neural Plast
– volume: 291
  start-page: 21
  year: 2011
  end-page: 71
  article-title: New insights into the mechanism of Wnt signaling pathway activation
  publication-title: Int Rev Cell Mol Biol
– volume: 3
  start-page: 957
  year: 2014
  end-page: 64
  article-title: Purification and ex vivo expansion of fully functional salivary gland stem cells
  publication-title: Stem Cell Reports
– volume: 20
  year: 2020
  article-title: Semaphorin 3A mediated brain tumor stem cell proliferation and invasion in EGFRviii mutant gliomas
  publication-title: BMC Cancer
– volume: 18
  start-page: 618
  year: 2012
  end-page: 23
  article-title: Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell
  publication-title: Nature Med
– volume: 160
  start-page: 299
  year: 2015
  end-page: 312
  article-title: Long‐term culture of genome‐stable bipotent stem cells from adult human liver
  publication-title: Cell
– volume: 1710
  start-page: 209
  year: 2019
  end-page: 19
  article-title: Remarkable complexity and variability of corticospinal tract defects in adult Semaphorin 6A knockout mice
  publication-title: Brain Res
– volume: 37
  start-page: 565
  year: 2008
  end-page: 70
  article-title: Mutational analysis of Wnt signaling molecules in ameloblastoma with aberrant nuclear expression of β‐catenin: Wnt signaling molecules in ameloblastoma
  publication-title: J Oral Pathol Med
– volume: 418
  year: 2002
  article-title: RAF/RAS oncogenes and mismatch‐repair status
  publication-title: Nature
– volume: 26
  start-page: 5577
  year: 2007
  end-page: 86
  article-title: Neuropilin‐1 promotes human glioma progression through potentiating the activity of the HGF/SF autocrine pathway
  publication-title: Oncogene
– volume: 111
  start-page: 16401
  year: 2014
  end-page: 6
  article-title: Single Lgr5‐ or Lgr6‐expressing taste stem/progenitor cells generate taste bud cells ex vivo
  publication-title: Proc Nat Acad Sci
– volume: 9
  start-page: M53
  year: 1999
  end-page: 6
  article-title: Signalling networks that cause cancer
  publication-title: Trends Cell Biol
– volume: 36
  start-page: 234
  year: 2005
  end-page: 41
  article-title: Abnormal β‐catenin expression in oral cancer with no gene mutation: correlation with expression of cyclin D1 and epidermal growth factor receptor, Ki‐67 labeling index, and clinicopathological features
  publication-title: Hum Pathol
– volume: 10
  start-page: 641
  year: 2016
  end-page: 51
  article-title: Class 3 semaphorins in cardiovascular development
  publication-title: Cell Adh Migr
– volume: 40
  start-page: 1291
  year: 2008
  end-page: 9
  article-title: Lgr5 marks cycling, yet long‐lived, hair follicle stem cells
  publication-title: Nature Genet
– volume: 253
  start-page: 665
  year: 1991
  end-page: 9
  article-title: Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
  publication-title: Science
– volume: 13
  start-page: 604
  year: 2007
  end-page: 12
  article-title: Sema3a maintains normal heart rhythm through sympathetic innervation patterning
  publication-title: Nature Med
– volume: 136
  start-page: 1939
  year: 2009
  end-page: 49
  article-title: Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood
  publication-title: Development
– volume: 2
  start-page: 540
  year: 2012
  end-page: 52
  article-title: Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development
  publication-title: Cell Rep
– volume: 34
  start-page: 4834
  year: 2015
  end-page: 44
  article-title: Arl4c expression in colorectal and lung cancers promotes tumorigenesis and may represent a novel therapeutic target
  publication-title: Oncogene
– volume: 358
  start-page: 156
  year: 2011
  end-page: 67
  article-title: Coordination of epithelial branching and salivary gland lumen formation by Wnt and FGF signals
  publication-title: Dev Biol
– volume: 131
  start-page: 773
  year: 2005
  end-page: 82
  article-title: Mutations of the APC, beta‐catenin, and axin 1 genes and cytoplasmic accumulation of beta‐catenin in oral squamous cell carcinoma
  publication-title: J Cancer Res Clin Oncol
– volume: 398
  start-page: 714
  year: 1999
  end-page: 8
  article-title: p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
  publication-title: Nature
– volume: 56
  start-page: 186
  year: 2013
  end-page: 200
  article-title: The chemorepulsive axon guidance protein semaphorin3A is a constituent of perineuronal nets in the adult rodent brain
  publication-title: Mol Cell Neurosci
– volume: 7
  start-page: 81571
  year: 2016
  end-page: 87
  article-title: Epigenetic upregulation of ARL4C, due to DNA hypomethylation in the 3'‐untranslated region, promotes tumorigenesis of lung squamous cell carcinoma
  publication-title: Oncotarget
– volume: 6
  year: 2011
  article-title: Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair
  publication-title: PLoS One
– volume: 7
  start-page: 51733
  year: 2016
  end-page: 46
  article-title: Overexpression of semaphorin 3A promotes tumor progression and predicts poor prognosis in hepatocellular carcinoma after curative resection
  publication-title: Oncotarget
– volume: 17
  start-page: 1371
  year: 1998
  end-page: 84
  article-title: Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK‐3beta and beta ‐catenin and promotes GSK‐3beta ‐dependent phosphorylation of beta ‐catenin
  publication-title: EMBO J
– volume: 318
  start-page: 1108
  year: 2007
  end-page: 13
  article-title: The genomic landscapes of human breast and colorectal cancers
  publication-title: Science
– volume: 12
  year: 2014
  article-title: Brain endothelial cells control fertility through ovarian‐steroid‐dependent release of semaphorin 3A
  publication-title: PLoS Biol
– volume: 19
  start-page: 119
  year: 2009
  end-page: 29
  article-title: Selective activation mechanisms of Wnt signaling pathways
  publication-title: Trends Cell Biol
– volume: 87
  start-page: 159
  year: 1996
  end-page: 70
  article-title: Lessons from hereditary colorectal cancer
  publication-title: Cell
– volume: 9
  year: 2017
  article-title: Immunoexpression of Wnt/β‐catenin signaling pathway proteins in ameloblastoma and calcifying cystic odontogenic tumor
  publication-title: J Clin Exp Dent
– volume: 228
  start-page: 300
  year: 2012
  end-page: 9
  article-title: Developmental stage‐specific contribution of LGR5(+) cells to basal and luminal epithelial lineages in the postnatal mammary gland
  publication-title: J Pathol
– volume: 20
  start-page: 963
  year: 2005
  end-page: 9
  article-title: Wild‐type and mutant B‐RAF activate C‐RAF through distinct mechanisms involving heterodimerization
  publication-title: Mol Cell
– volume: 423
  start-page: 337
  year: 2003
  end-page: 42
  article-title: Osteoclast differentiation and activation
  publication-title: Nature
– volume: 169
  start-page: 985
  year: 2017
  end-page: 99
  article-title: Wnt/β‐catenin signaling, disease, and emerging therapeutic modalities
  publication-title: Cell
– volume: 41
  start-page: 332
  year: 2012
  end-page: 9
  article-title: Differential expression of canonical and non‐canonical Wnt ligands in ameloblastoma
  publication-title: J Oral Pathol Med
– volume: 10
  year: 2021
  article-title: Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion
  publication-title: eLife
– volume: 31
  start-page: 992
  year: 2013
  end-page: 1000
  article-title: Lgr5‐EGFP marks taste bud stem/progenitor cells in posterior tongue
  publication-title: Stem Cells
– volume: 49
  start-page: 82
  year: 2014
  end-page: 6
  article-title: The natural history of familial adenomatous polyposis syndrome: a 24 year review of a single center experience in screening, diagnosis, and outcomes
  publication-title: J Pediatr Surg
– volume: 25
  start-page: 4014
  year: 2021
  end-page: 27
  article-title: ARL4C might serve as a prognostic factor and a novel therapeutic target for gastric cancer: bioinformatics analyses and biological experiments
  publication-title: J Cell Mol Med
– volume: 132
  year: 2019
  article-title: Mark1 regulates distal airspace expansion through type I pneumocyte flattening in lung development
  publication-title: J Cell Sci
– volume: 423
  start-page: 448
  year: 2003
  end-page: 52
  article-title: Wnt proteins are lipid‐modified and can act as stem cell growth factors
  publication-title: Nature
– volume: 70
  start-page: 224
  year: 2020
  end-page: 30
  article-title: An immunohistochemical and genetic study of BRAF(V600E) mutation in Japanese patients with ameloblastoma
  publication-title: Pathol Int
– volume: 449
  start-page: 1003
  year: 2007
  end-page: 7
  article-title: Identification of stem cells in small intestine and colon by marker gene Lgr5
  publication-title: Nature
– volume: 23
  start-page: e107
  year: 2017
  end-page: 14
  article-title: Cancer screening recommendations and clinical management of inherited gastrointestinal cancer syndromes in childhood
  publication-title: Clin Cancer Res
– volume: 144
  start-page: 151
  year: 2017
  end-page: 62
  article-title: Modulation of apical constriction by Wnt signaling is required for lung epithelial shape transition
  publication-title: Development
– volume: 214
  start-page: 586
  year: 2018
  end-page: 92
  article-title: Wnt/β‐catenin signal alteration and its diagnostic utility in basal cell adenoma and histologically similar tumors of the salivary gland
  publication-title: Pathol Res Prac
– volume: 111
  start-page: 951
  year: 2020
  end-page: 61
  article-title: ARL4C is associated with initiation and progression of lung adenocarcinoma and represents a therapeutic target
  publication-title: Cancer Sci
– volume: 9
  year: 2019
  article-title: Wnt/β‐catenin signaling, which is activated in odontomas, reduces Sema3A expression to regulate odontogenic epithelial cell proliferation and tooth germ development
  publication-title: Sci Rep
– start-page: 215
  year: 2017
  end-page: 8
– volume: 46
  start-page: 722
  year: 2014
  end-page: 5
  article-title: Identification of recurrent SMO and BRAF mutations in ameloblastomas
  publication-title: Nature Genet
– volume: 17
  start-page: 1475
  year: 2004
  end-page: 82
  article-title: Mutations in components of the Wnt signaling pathway in adenoid cystic carcinoma
  publication-title: Mod Pathol
– volume: 109
  start-page: E812
  year: 2012
  end-page: 20
  article-title: Wnt/β‐catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled
  publication-title: Proc Nat Acad Sci
– volume: 467
  start-page: 338
  year: 2010
  end-page: 42
  article-title: Comprehensive methylome map of lineage commitment from haematopoietic progenitors
  publication-title: Nature
– volume: 314
  start-page: 1458
  year: 2006
  end-page: 61
  article-title: PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane
  publication-title: Science
– volume: 57
  start-page: 10
  year: 2013
  end-page: 22
  article-title: Modulation of semaphorin3A in perineuronal nets during structural plasticity in the adult cerebellum
  publication-title: Mol Cell Neurosci
– volume: 37
  start-page: 3313
  year: 2017
  end-page: 20
  article-title: Novel role of semaphorin 3A in the growth and progression of hepatocellular carcinoma
  publication-title: Oncol Rep
– volume: 22
  start-page: 454
  year: 2018
  end-page: 67
  article-title: Human pancreatic tumor organoids reveal loss of stem cell niche factor dependence during disease progression
  publication-title: Cell Stem Cell
– volume: 32
  start-page: 2708
  year: 2013
  end-page: 21
  article-title: Unlimited in vitro expansion of adult bi‐potent pancreas progenitors through the Lgr5/R‐spondin axis
  publication-title: EMBO J
– volume: 129
  start-page: 4831
  year: 2002
  end-page: 42
  article-title: Wnt7b regulates mesenchymal proliferation and vascular development in the lung
  publication-title: Development
– volume: 33
  start-page: 316
  year: 1997
  end-page: 28
  article-title: A novel action of collapsin: collapsin‐1 increases antero‐ and retrograde axoplasmic transport independently of growth cone collapse
  publication-title: J Neurobiol
– volume: 229
  start-page: 722
  year: 2004
  end-page: 32
  article-title: Sonic hedgehog signaling plays an essential role during embryonic salivary gland epithelial branching morphogenesis
  publication-title: Dev Dyn
– volume: 382
  start-page: 638
  year: 1996
  end-page: 42
  article-title: Functional interaction of β‐catenin with the transcription factor LEF‐1
  publication-title: Nature
– volume: 566
  start-page: 241
  year: 2004
  end-page: 6
  article-title: ADP‐ribosylation factor (ARF)‐like 7 (ARL7) is induced by cholesterol loading and participates in apolipoprotein AI‐dependent cholesterol export
  publication-title: FEBS Lett
– volume: 14
  start-page: 398
  year: 1999
  end-page: 418
  article-title: Differential cytoskeletal changes during growth cone collapse in response to hSema III and thrombin
  publication-title: Mol Cell Neurosci
– volume: 3
  start-page: 1035
  year: 2002
  end-page: 41
  article-title: Arf, Arl, Arp and Sar proteins: a family of GTP‐binding proteins with a structural device for ‘front‐back' communication
  publication-title: EMBO Rep
– volume: 45
  start-page: 791
  year: 2013
  end-page: 8
  article-title: The mutational landscape of adenoid cystic carcinoma
  publication-title: Nature Genet
– volume: 4
  year: 2012
  article-title: Signaling networks regulating tooth organogenesis and regeneration, and the specification of dental mesenchymal and epithelial cell lineages
  publication-title: Cold Spring Harbor Perspect Biol
– volume: 18
  year: 2017
  article-title: Sema3A drastically suppresses tumor growth in oral cancer Xenograft model of mice
  publication-title: BMC Pharmacol Toxicol
– volume: 14
  start-page: 687
  year: 2004
  end-page: 94
  article-title: Arf‐like GTPases: not so Arf‐like after all
  publication-title: Trends Cell Biol
– year: 2015
– volume: 23
  start-page: 1001
  year: 2003
  end-page: 7
  article-title: Correlation between protein expression and epigenetic and mutation changes of Wnt pathway‐related genes in oral cancer
  publication-title: Int J Oncol
– volume: 256
  start-page: 119
  year: 2022
  end-page: 33
  article-title: RAF1‐MEK/ERK pathway‐dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation
  publication-title: J Pathol
– volume: 236
  year: 2022
  article-title: The Semaphorin 3A‐AKT axis‐mediated cell proliferation in salivary gland morphogenesis and adenoid cystic carcinoma pathogenesis
  publication-title: Pathol Res Prac
– volume: 28
  start-page: 3537
  year: 2009
  end-page: 50
  article-title: Autocrine semaphorin 3A signaling promotes glioblastoma dispersal
  publication-title: Oncogene
– volume: 17
  start-page: 290
  year: 2009
  end-page: 8
  article-title: Wnt2/2b and β‐catenin signaling are necessary and sufficient to specify lung progenitors in the foregut
  publication-title: Dev Cell
– volume: 144
  start-page: 1065
  year: 2017
  end-page: 71
  article-title: Derivation of a robust mouse mammary organoid system for studying tissue dynamics
  publication-title: Development
– volume: 109
  start-page: 8167
  year: 2012
  end-page: 72
  article-title: Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea
  publication-title: Proc Nat Acad Sci
– volume: 9
  start-page: 701
  year: 2014
  end-page: 11
  article-title: Cellular heterogeneity in the mouse esophagus implicates the presence of a nonquiescent epithelial stem cell population
  publication-title: Cell Rep
– volume: 48
  start-page: 997
  year: 2012
  end-page: 1006
  article-title: Epithelial to mesenchymal transition (EMT) biomarkers‐‐E‐cadherin, beta‐catenin, APC and Vimentin‐‐in oral squamous cell carcinogenesis and transformation
  publication-title: Oral Oncol
– volume: 149
  start-page: 877
  year: 2003
  end-page: 83
  article-title: The concomitant occurrence of multiple epidermal cysts, osteomas and thyroid gland nodules is not diagnostic for Gardner syndrome in the absence of intestinal polyposis: a clinical and genetic report
  publication-title: Br J Dermatol
– volume: 174
  start-page: 856
  year: 2018
  end-page: 69
  article-title: Divergent routes toward Wnt and R‐spondin niche independency during human gastric carcinogenesis
  publication-title: Cell
– volume: 272
  start-page: 1023
  year: 1996
  end-page: 6
  article-title: Binding of GSK3β to the APC‐β‐catenin complex and regulation of complex assembly
  publication-title: Science
– volume: 6
  start-page: 25
  year: 2010
  end-page: 36
  article-title: Lgr5(+ve) stem cells drive self‐renewal in the stomach and build long‐lived gastric units in vitro
  publication-title: Cell Stem Cell
– volume: 9
  start-page: 415
  year: 2019
  end-page: 23
  article-title: ADP‐ribosylation factor‐like 4C is a predictive biomarker of poor prognosis in patients with renal cell carcinoma
  publication-title: Am J Cancer Res
– volume: 24
  start-page: 223
  year: 2019
  end-page: 29
  article-title: ADP‐ribosylation factor‐like 4C predicts worse prognosis in endometriosis‐associated ovarian cancers
  publication-title: Cancer Biomark
– volume: 75
  start-page: 217
  year: 1993
  end-page: 27
  article-title: Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones
  publication-title: Cell
– volume: 13
  start-page: 51
  year: 1995
  end-page: 6
  article-title: Gardner's syndrome
  publication-title: Dermatol Clin
– volume: 235
  year: 2022
  article-title: Clear cell squamous cell carcinoma of the tongue exhibits characteristics as an undifferentiated squamous cell carcinoma
  publication-title: Pathol Res Prac
– volume: 247
  start-page: 818
  year: 2018
  end-page: 31
  article-title: A novel role for cilia‐dependent sonic hedgehog signaling during submandibular gland development
  publication-title: Dev Dyn
– volume: 277
  start-page: 316
  year: 2005
  end-page: 31
  article-title: Dickkopf‐1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung
  publication-title: Dev Biol
– start-page: 108
  year: 2017
  end-page: 11
– volume: 6
  year: 2015
  article-title: The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids
  publication-title: Nat Commun
– volume: 160
  start-page: 324
  year: 2015
  end-page: 38
  article-title: Organoid models of human and mouse ductal pancreatic cancer
  publication-title: Cell
– volume: 115
  start-page: 4433
  year: 2002
  end-page: 45
  article-title: A developmentally regulated ARF‐like 5 protein (ARL5), localized to nuclei and nucleoli, interacts with heterochromatin protein 1
  publication-title: J Cell Sci
– volume: 516
  start-page: 400
  year: 2014
  end-page: 4
  article-title: Modelling human development and disease in pluripotent stem‐cell‐derived gastric organoids
  publication-title: Nature
– volume: 630
  start-page: 64
  year: 2022
  end-page: 70
  article-title: Wnt signaling promotes tooth germ development through YAP1‐TGF‐β signaling
  publication-title: Biochem Biophys Res Commun
– volume: 20
  start-page: 5517
  year: 2014
  end-page: 26
  article-title: Activating FGFR2‐RAS‐BRAF mutations in ameloblastoma
  publication-title: Clin Cancer Res
– volume: 395
  start-page: 521
  year: 1998
  end-page: 5
  article-title: Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling
  publication-title: Nature
– volume: 20
  start-page: 156
  year: 2021
  end-page: 69
  article-title: Somatic cell‐derived organoids as prototypes of human epithelial tissues and diseases
  publication-title: Nat Mater
– volume: 278
  start-page: 40231
  year: 2003
  end-page: 8
  article-title: β‐Catenin is required for specification of proximal/distal cell fate during lung morphogenesis
  publication-title: J Biol Chem
– volume: 15
  start-page: 511
  year: 2013
  end-page: 8
  article-title: Identification of stem cells that maintain and regenerate lingual keratinized epithelial cells
  publication-title: Nature Cell Biol
– volume: 75
  start-page: 1389
  year: 1993
  end-page: 99
  article-title: The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules
  publication-title: Cell
– volume: 29
  start-page: 12542
  year: 2009
  end-page: 57
  article-title: Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting
  publication-title: J Neurosci
– ident: e_1_2_16_114_1
  doi: 10.1002/path.5189
– ident: e_1_2_16_23_1
  doi: 10.1038/26785
– ident: e_1_2_16_36_1
  doi: 10.1046/j.1365-2133.2003.05640.x
– ident: e_1_2_16_101_1
  doi: 10.1093/jb/mvw069
– ident: e_1_2_16_32_1
  doi: 10.1242/jcs.235556
– ident: e_1_2_16_120_1
  doi: 10.1038/nature09367
– ident: e_1_2_16_6_1
  doi: 10.1038/ng.2643
– ident: e_1_2_16_91_1
  doi: 10.1126/science.1848370
– ident: e_1_2_16_137_1
  doi: 10.1016/0092-8674(93)80064-L
– ident: e_1_2_16_142_1
  doi: 10.1155/2016/3679545
– ident: e_1_2_16_153_1
  doi: 10.1002/dvdy.24627
– ident: e_1_2_16_65_1
  doi: 10.1038/nature13863
– ident: e_1_2_16_27_1
  doi: 10.1242/dev.015495
– volume: 9
  start-page: 415
  year: 2019
  ident: e_1_2_16_112_1
  article-title: ADP‐ribosylation factor‐like 4C is a predictive biomarker of poor prognosis in patients with renal cell carcinoma
  publication-title: Am J Cancer Res
– ident: e_1_2_16_88_1
  doi: 10.1111/j.1600-0714.2011.01104.x
– ident: e_1_2_16_157_1
  doi: 10.3892/or.2017.5616
– ident: e_1_2_16_90_1
  doi: 10.1016/j.prp.2017.12.016
– ident: e_1_2_16_33_1
  doi: 10.1111/j.1469-7580.2008.01014.x
– ident: e_1_2_16_35_1
  doi: 10.1016/j.jpedsurg.2013.09.033
– ident: e_1_2_16_56_1
  doi: 10.1016/j.celrep.2012.08.018
– ident: e_1_2_16_163_1
  doi: 10.1186/s40360-017-0163-4
– ident: e_1_2_16_64_1
  doi: 10.1053/j.gastro.2014.09.042
– ident: e_1_2_16_139_1
  doi: 10.1016/j.mcn.2013.08.003
– ident: e_1_2_16_146_1
  doi: 10.1016/j.brainres.2018.12.041
– ident: e_1_2_16_109_1
  doi: 10.1038/onc.2014.402
– ident: e_1_2_16_34_1
  doi: 10.1158/1078-0432.CCR-17-0790
– ident: e_1_2_16_39_1
  doi: 10.1111/j.1601-0825.2006.01293.x
– ident: e_1_2_16_141_1
  doi: 10.1371/journal.pbio.1001808
– ident: e_1_2_16_145_1
  doi: 10.1523/JNEUROSCI.2521-09.2009
– ident: e_1_2_16_107_1
  doi: 10.1242/jcs.00123
– ident: e_1_2_16_31_1
  doi: 10.1242/dev.141325
– ident: e_1_2_16_73_1
  doi: 10.1016/j.celrep.2014.09.027
– volume: 9
  year: 2017
  ident: e_1_2_16_89_1
  article-title: Immunoexpression of Wnt/β‐catenin signaling pathway proteins in ameloblastoma and calcifying cystic odontogenic tumor
  publication-title: J Clin Exp Dent
– ident: e_1_2_16_140_1
  doi: 10.1016/j.mcn.2013.04.009
– ident: e_1_2_16_9_1
  doi: 10.1101/cshperspect.a008425
– ident: e_1_2_16_115_1
  doi: 10.1111/cas.14303
– ident: e_1_2_16_43_1
  doi: 10.1016/j.ydbio.2011.07.023
– ident: e_1_2_16_48_1
  doi: 10.1016/S1534-5807(02)00167-3
– ident: e_1_2_16_83_1
  doi: 10.1016/j.oraloncology.2004.04.011
– ident: e_1_2_16_134_1
  doi: 10.1038/nature01658
– ident: e_1_2_16_158_1
  doi: 10.18632/oncotarget.10104
– ident: e_1_2_16_10_1
  doi: 10.1242/dev.134486
– ident: e_1_2_16_143_1
  doi: 10.1080/19336918.2016.1243644
– ident: e_1_2_16_100_1
  doi: 10.1016/j.tcb.2004.10.004
– ident: e_1_2_16_18_1
  doi: 10.1073/pnas.1114802109
– ident: e_1_2_16_42_1
  doi: 10.1016/j.bbrc.2022.09.012
– ident: e_1_2_16_51_1
  doi: 10.1038/nature06196
– ident: e_1_2_16_57_1
  doi: 10.1038/ncb3000
– ident: e_1_2_16_155_1
  doi: 10.1038/onc.2009.204
– ident: e_1_2_16_123_1
  doi: 10.1016/j.febslet.2004.04.048
– ident: e_1_2_16_150_1
  doi: 10.1242/dev.00172
– ident: e_1_2_16_159_1
  doi: 10.1186/s12885-020-07694-4
– ident: e_1_2_16_37_1
  doi: 10.1016/S0733-8635(18)30106-2
– ident: e_1_2_16_44_1
  doi: 10.1016/j.devcel.2015.01.023
– ident: e_1_2_16_59_1
  doi: 10.1002/stem.1338
– ident: e_1_2_16_49_1
  doi: 10.1038/nature01593
– ident: e_1_2_16_95_1
  doi: 10.1038/sj.onc.1209824
– ident: e_1_2_16_135_1
  doi: 10.1016/S0959-4388(03)00003-5
– ident: e_1_2_16_104_1
  doi: 10.1038/nrm3117
– ident: e_1_2_16_17_1
  doi: 10.1093/emboj/17.5.1371
– ident: e_1_2_16_67_1
  doi: 10.1038/nature15695
– ident: e_1_2_16_126_1
  doi: 10.1016/j.prp.2022.153909
– ident: e_1_2_16_133_1
  doi: 10.1038/418934a
– ident: e_1_2_16_118_1
  doi: 10.1016/S0962-8924(99)01668-2
– ident: e_1_2_16_26_1
  doi: 10.1242/dev.129.20.4831
– ident: e_1_2_16_97_1
  doi: 10.1126/science.275.5307.1784
– ident: e_1_2_16_96_1
  doi: 10.1126/science.272.5264.1023
– ident: e_1_2_16_117_1
  doi: 10.7554/eLife.66721
– ident: e_1_2_16_154_1
  doi: 10.1016/j.prp.2022.153991
– start-page: 108
  volume-title: WHO classification of head and neck tumours
  year: 2017
  ident: e_1_2_16_2_1
– ident: e_1_2_16_7_1
  doi: 10.1038/nature14129
– volume: 2022
  start-page: 1
  year: 2022
  ident: e_1_2_16_122_1
  article-title: ARL4C regulates the progression of clear cell renal cell carcinoma by affecting the Wnt/β‐Catenin signaling pathway
  publication-title: J Oncol
– volume: 7
  start-page: 4782
  year: 2014
  ident: e_1_2_16_161_1
  article-title: Decreased expression of SEMA3A is associated with poor prognosis in gastric carcinoma
  publication-title: Int J Clin Exp Pathol
– ident: e_1_2_16_24_1
  doi: 10.1074/jbc.M305892200
– ident: e_1_2_16_86_1
  doi: 10.1016/j.oraloncology.2012.05.011
– ident: e_1_2_16_75_1
  doi: 10.1242/dev.145045
– ident: e_1_2_16_152_1
  doi: 10.1002/dvdy.10472
– ident: e_1_2_16_72_1
  doi: 10.1016/j.celrep.2017.01.066
– ident: e_1_2_16_82_1
  doi: 10.1007/s00432-005-0027-y
– ident: e_1_2_16_30_1
  doi: 10.1073/pnas.1201583109
– ident: e_1_2_16_46_1
  doi: 10.1038/s41563-020-0754-0
– ident: e_1_2_16_60_1
  doi: 10.1002/path.4096
– ident: e_1_2_16_128_1
  doi: 10.1002/path.4317
– ident: e_1_2_16_21_1
  doi: 10.1016/B978-0-12-386035-4.00002-1
– ident: e_1_2_16_113_1
  doi: 10.3233/CBM-181836
– ident: e_1_2_16_62_1
  doi: 10.1038/nature07935
– ident: e_1_2_16_76_1
  doi: 10.1016/j.stemcr.2015.11.009
– ident: e_1_2_16_131_1
  doi: 10.1111/pin.12899
– ident: e_1_2_16_61_1
  doi: 10.1038/ncb2719
– ident: e_1_2_16_87_1
  doi: 10.1111/j.1600-0714.2008.00645.x
– ident: e_1_2_16_84_1
  doi: 10.1016/j.humpath.2004.12.009
– ident: e_1_2_16_136_1
  doi: 10.1080/19336918.2016.1212805
– ident: e_1_2_16_149_1
  doi: 10.1038/nm1570
– ident: e_1_2_16_93_1
  doi: 10.1016/S0092-8674(00)81333-1
– ident: e_1_2_16_103_1
  doi: 10.1242/jcs.02958
– ident: e_1_2_16_16_1
  doi: 10.1016/j.tcb.2009.01.003
– ident: e_1_2_16_80_1
  doi: 10.1016/j.cell.2018.07.027
– ident: e_1_2_16_94_1
  doi: 10.1126/science.1145720
– ident: e_1_2_16_55_1
  doi: 10.1038/nature11826
– ident: e_1_2_16_127_1
  doi: 10.1002/path.5814
– ident: e_1_2_16_162_1
  doi: 10.18632/oncotarget.6831
– ident: e_1_2_16_92_1
  doi: 10.1126/science.1651563
– ident: e_1_2_16_130_1
  doi: 10.1158/1078-0432.CCR-14-1069
– ident: e_1_2_16_69_1
  doi: 10.1038/ncb3047
– ident: e_1_2_16_160_1
  doi: 10.1093/carcin/bgy106
– ident: e_1_2_16_66_1
  doi: 10.1016/j.cell.2014.11.050
– ident: e_1_2_16_11_1
  doi: 10.1038/modpathol.3800209
– ident: e_1_2_16_14_1
  doi: 10.1002/embj.201386942
– ident: e_1_2_16_25_1
  doi: 10.1016/j.devcel.2009.06.005
– ident: e_1_2_16_63_1
  doi: 10.1038/nm.2695
– ident: e_1_2_16_29_1
  doi: 10.1016/j.ydbio.2004.09.023
– ident: e_1_2_16_53_1
  doi: 10.1016/j.stem.2009.11.013
– ident: e_1_2_16_77_1
  doi: 10.1016/j.stemcr.2014.09.015
– ident: e_1_2_16_147_1
  doi: 10.1002/(SICI)1097-4695(199709)33:3<316::AID-NEU9>3.0.CO;2-4
– ident: e_1_2_16_129_1
  doi: 10.1038/ng.2986
– ident: e_1_2_16_148_1
  doi: 10.1006/mcne.1999.0777
– volume: 23
  start-page: 1001
  year: 2003
  ident: e_1_2_16_85_1
  article-title: Correlation between protein expression and epigenetic and mutation changes of Wnt pathway‐related genes in oral cancer
  publication-title: Int J Oncol
– ident: e_1_2_16_74_1
  doi: 10.1038/ncomms9989
– ident: e_1_2_16_15_1
  doi: 10.1038/s41598-019-39686-1
– ident: e_1_2_16_106_1
  doi: 10.1074/jbc.M002470200
– ident: e_1_2_16_22_1
  doi: 10.1038/382638a0
– volume: 7
  start-page: 1383
  year: 1996
  ident: e_1_2_16_45_1
  article-title: Complex regulation of human c‐kit transcription by promoter repressors, activators, and specific myb elements
  publication-title: Cell Growth Differ
– ident: e_1_2_16_99_1
  doi: 10.1093/embo-reports/kvf221
– ident: e_1_2_16_5_1
  doi: 10.1002/cncr.27408
– ident: e_1_2_16_47_1
  doi: 10.1242/dev.126.20.4557
– ident: e_1_2_16_8_1
  doi: 10.1016/j.cell.2017.05.016
– ident: e_1_2_16_119_1
  doi: 10.2147/OTT.S282992
– ident: e_1_2_16_105_1
  doi: 10.1016/j.cub.2007.03.007
– ident: e_1_2_16_28_1
  doi: 10.1371/journal.pone.0023139
– ident: e_1_2_16_3_1
  doi: 10.1016/j.oraloncology.2008.06.002
– ident: e_1_2_16_38_1
  doi: 10.1016/S0901-5027(05)80641-1
– ident: e_1_2_16_12_1
  doi: 10.1073/pnas.0607289103
– ident: e_1_2_16_111_1
  doi: 10.1245/s10434-017-6292-6
– ident: e_1_2_16_116_1
  doi: 10.1111/jcmm.16366
– ident: e_1_2_16_151_1
  doi: 10.1242/dev.121.4.1015
– ident: e_1_2_16_138_1
  doi: 10.1016/0092-8674(93)90625-Z
– ident: e_1_2_16_156_1
  doi: 10.1038/sj.onc.1210348
– ident: e_1_2_16_52_1
  doi: 10.1038/ng.239
– ident: e_1_2_16_78_1
  doi: 10.1016/j.stem.2016.04.003
– ident: e_1_2_16_98_1
  doi: 10.1016/j.gde.2006.12.007
– ident: e_1_2_16_124_1
  doi: 10.1016/j.bbrc.2009.04.125
– start-page: 215
  volume-title: WHO classification of head and neck tumours
  year: 2017
  ident: e_1_2_16_4_1
– ident: e_1_2_16_19_1
  doi: 10.1038/nsmb1247
– ident: e_1_2_16_108_1
  doi: 10.1126/science.1134389
– ident: e_1_2_16_144_1
  doi: 10.1523/JNEUROSCI.23-17-06671.2003
– ident: e_1_2_16_79_1
  doi: 10.1016/j.stem.2017.12.009
– ident: e_1_2_16_121_1
  doi: 10.18632/oncotarget.13147
– ident: e_1_2_16_68_1
  doi: 10.1016/j.cell.2014.12.021
– ident: e_1_2_16_50_1
  doi: 10.1038/nature01611
– ident: e_1_2_16_125_1
  doi: 10.1038/19539
– ident: e_1_2_16_132_1
  doi: 10.1016/j.molcel.2005.10.022
– ident: e_1_2_16_54_1
  doi: 10.1038/emboj.2013.204
– ident: e_1_2_16_13_1
  doi: 10.1242/dev.033803
– ident: e_1_2_16_58_1
  doi: 10.1073/pnas.1202774109
– ident: e_1_2_16_70_1
  doi: 10.1016/j.cell.2014.08.017
– ident: e_1_2_16_81_1
  doi: 10.1038/s41586-022-05043-y
– ident: e_1_2_16_40_1
  doi: 10.7150/ijms.10501
– ident: e_1_2_16_41_1
  doi: 10.2337/diabetes.52.3.588
– ident: e_1_2_16_2_2
– ident: e_1_2_16_110_1
  doi: 10.1158/1535-7163.MCT-18-0824
– ident: e_1_2_16_20_1
  doi: 10.1073/pnas.1017063108
– ident: e_1_2_16_71_1
  doi: 10.1073/pnas.1409064111
– ident: e_1_2_16_102_1
  doi: 10.1016/S0014-5793(99)00759-0
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Snippet Various types of tumors, including malignant and benign ones, occur in the oral cavity. These arise from the mucosal epithelium, odontogenic epithelium, and...
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SubjectTerms ACC
Adenoid
Ameloblastoma
ARL4C
Catenin
developmental process
Epithelium
Homeostasis
Oral carcinoma
Oral cavity
Oral squamous cell carcinoma
OSCC
Pathogenesis
Phosphates
Ribosylation
Salivary gland
Salivary glands
Sema3A
Semaphorins
Signal transduction
tumor formation
Tumors
Wnt
Wnt protein
Title The role of Wnt, ARL4C, and Sema3A in developmental process and disease pathogenesis
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fpin.13325
https://www.ncbi.nlm.nih.gov/pubmed/37098842
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