Intra‐Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof‐of‐Concept Clinical Trial

• Published in: Stem cells (Dayton, Ohio) Vol. 32; no. 5; pp. 1254 - 1266
• Main Authors: Jo, Chris Hyunchul, Lee, Young Gil, Shin, Won Hyoung, Kim, Hyang, Chai, Jee Won, Jeong, Eui Cheol, Kim, Ji Eun, Shim, Hackjoon, Shin, Ji Sun, Shin, Il Seob, Ra, Jeong Chan, Oh, Sohee, Yoon, Kang Sup
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.05.2014
• Subjects: Adipose Tissue - cytology; Adipose‐tissue derived mesenchymal stem cells; Aged; Arthralgia - etiology; Cartilage regeneration; Cartilage, Articular - diagnostic imaging; Cartilage, Articular - pathology; Cartilage, Articular - physiopathology; Cohort Studies; Female; Humans; Injections, Intra-Articular; Intra‐articular injection; Knee - physiopathology; Male; Mesenchymal Stem Cell Transplantation - adverse effects; Mesenchymal Stem Cell Transplantation - methods; Mesenchymal Stromal Cells - cytology; Middle Aged; Osteoarthritis; Osteoarthritis, Knee - therapy; Pain - etiology; Radiography; Regeneration; Transplantation, Autologous; Treatment Outcome; Urinary Calculi - etiology; Cartilage regeneration; Intra-articular injection; Adipose-tissue derived mesenchymal stem cells; Osteoarthritis

Mesenchymal stem cells (MSCs) are known to have a potential for articular cartilage regeneration. However, most studies focused on focal cartilage defect through surgical implantation. For the treatment of generalized cartilage loss in osteoarthritis, an alternative delivery strategy would be more a...