Elevated body mass index as a causal risk factor for symptomatic gallstone disease: A Mendelian randomization study

• Published in: Hepatology (Baltimore, Md.) Vol. 58; no. 6; pp. 2133 - 2141
• Main Authors: Stender, Stefan, Nordestgaard, Børge G., Tybjærg‐Hansen, Anne
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.12.2013
• Subjects: Aged; Alleles; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Body Mass Index; Confidence intervals; Confounding Factors (Epidemiology); Denmark; Female; Gallstones; Gallstones - genetics; Hepatology; Humans; Male; Membrane Proteins - genetics; Men; Middle Aged; Obesity - complications; Obesity - genetics; Odds Ratio; Proteins - genetics; Random Allocation; Receptor, Melanocortin, Type 4 - genetics; Risk Factors; Women

Elevated body mass index (BMI) is associated with an increased risk of gallstone disease. Whether this reflects a causal association is unknown. Using a Mendelian randomization approach, we studied 77,679 individuals from the general population. Of these, 4,106 developed symptomatic gallstone diseas...