IL‐30 (IL27p28) attenuates liver fibrosis through inducing NKG2D‐rae1 interaction between NKT and activated hepatic stellate cells in mice

• Published in: Hepatology (Baltimore, Md.) Vol. 60; no. 6; pp. 2027 - 2039
• Main Authors: Mitra, Abhisek, Satelli, Arun, Yan, Jun, Xueqing, Xia, Gagea, Mihai, Hunter, Christopher A., Mishra, Lopa, Li, Shulin
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.12.2014
• Subjects: Animals; Carbon Tetrachloride; Drug Evaluation, Preclinical; Female; Hepatic Stellate Cells - drug effects; Hepatic Stellate Cells - metabolism; Interleukins - pharmacology; Interleukins - therapeutic use; Ligands; Liver cirrhosis; Liver Cirrhosis - chemically induced; Liver Cirrhosis - drug therapy; Liver Cirrhosis - immunology; Mice, Inbred C57BL; Natural Killer T-Cells - drug effects; Natural Killer T-Cells - metabolism; NK Cell Lectin-Like Receptor Subfamily K - metabolism; Nuclear Matrix-Associated Proteins - metabolism; Nucleocytoplasmic Transport Proteins - metabolism; Pyridines; Rodents; T cell receptors

Chronic hepatic diseases, such as cirrhosis, hepatocellular carcinoma, and virus‐mediated immunopathogenic infections, affect billions of people worldwide. These diseases commonly initiate with fibrosis. Owing to the various side effects of antifibrotic therapy and the difficulty of diagnosing asymp...