Concise Review: Cell Therapies for Hereditary Metabolic Liver Diseases—Concepts, Clinical Results, and Future Developments

• Published in: Stem cells (Dayton, Ohio) Vol. 33; no. 4; pp. 1055 - 1062
• Main Authors: Cantz, Tobias, Sharma, Amar Deep, Ott, Michael
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.04.2015
• Subjects: Animals; Cell Differentiation - physiology; Cell- and Tissue-Based Therapy - methods; Cell- and Tissue-Based Therapy - trends; Cellular therapy; Clinical translation; Forecasting; Hepatic stem cells; Hepatocyte differentiation; Hepatocytes - transplantation; Humans; Liver; Liver diseases; Liver Diseases - metabolism; Liver Diseases - pathology; Liver Diseases - therapy; Liver Regeneration - physiology; Metabolism; Pluripotent stem cells; Progenitor cells; Stem Cell Transplantation - methods; Stem Cell Transplantation - trends; Stem cells; Transplants & implants; Hepatocyte differentiation; Liver; Cellular therapy; Clinical translation; Hepatic stem cells; Pluripotent stem cells; Progenitor cells

The concept of cell‐based therapies for inherited metabolic liver diseases has been introduced for now more than 40 years in animal experiments, but controlled clinical data in humans are still not available. In the era of dynamic developments in stem cell science, the “right” cell for transplantati...