Microtubule and microtubule associated protein anomalies in psychiatric disease

• Published in: Cytoskeleton (Hoboken, N.J.) Vol. 73; no. 10; pp. 596 - 611
• Main Authors: Marchisella, Francesca, Coffey, Eleanor T., Hollos, Patrik
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.10.2016; Wiley Subscription Services, Inc
• Subjects: Bipolar Disorder - genetics; Bipolar Disorder - metabolism; Bipolar Disorder - pathology; depression; Humans; JNK; MAP2; microtubule; Microtubule-Associated Proteins - genetics; Microtubule-Associated Proteins - metabolism; Microtubules - genetics; Microtubules - metabolism; Microtubules - physiology; Protein Processing, Post-Translational; schizophrenia; Schizophrenia - genetics; Schizophrenia - metabolism; Schizophrenia - pathology; Tubulin - genetics; Tubulin - metabolism; microtubule; depression; schizophrenia; MAP2; JNK

Anomalies in neuronal cell architecture, in particular dendritic complexity and synaptic density changes, are widely observed in the brains of subjects with schizophrenia or mood disorders. The concept that a disturbed microtubule cytoskeleton underlies these abnormalities and disrupts synaptic conn...