NOD2 contributes to cutaneous defense against Staphylococcus aureus through α-toxin-dependent innate immune activation - Hruz, Petr; Zinkernagel, Annelies S; Jenikova, Gabriela; Botwin, Gregory J; Hugot, Jean-Pierre; Karin, Michael; Nizet, Victor; Eckmann, Lars (Proceedings of the National Academy of Sciences - PNAS, 2009)
Keywords: Animals; Bacteria; Bacterial Toxins; Biological Sciences; cross infection; Cytokines; cytoplasm; endocarditis; Hemolysin Proteins - physiology; hemolysins; Immunity, Innate; Infections; innate immunity; Interleukin-1beta - biosynthesis; interleukin-6; Interleukin-6 - biosynthesis; Interleukin-8 - biosynthesis; intracellular signaling peptides and proteins; Lesions; Macrophages; Mice; Mice, Inbred C57BL; microbial detection; Neutrophil Activation; Neutrophils; Nod2 Signaling Adaptor Protein - physiology; oligomerization; Pathogens; peptidoglycans; pneumonia; Secretion; septicemia; Skin; Skin - immunology; Skin - microbiology; Staphylococcal Infections - immunology; Staphylococcus aureus; Staphylococcus aureus - immunology; Toll-like receptor 2; Toll-like receptor 4; toxins; virulence