MicroRNA-497 suppresses angiogenesis by targeting vascular endothelial growth factor A through the PI3K/AKT and MAPK/ERK pathways in ovarian cancer

• Published in: Oncology reports Vol. 32; no. 5; pp. 2127 - 2133
• Main Authors: WANG, WEI, REN, FANG, WU, QINGHUA, JIANG, DAZHI, LI, HONGJUN, SHI, HUIRONG
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.11.2014; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Adult; Aged; Aged, 80 and over; AKT; Angiogenesis; Binding sites; Breast cancer; Cancer; Cancer therapies; Cell growth; Cystadenocarcinoma, Serous - blood supply; Cystadenocarcinoma, Serous - genetics; Cystadenocarcinoma, Serous - pathology; ERK; Female; Gene Expression Regulation, Neoplastic; Humans; Immunoglobulins; MAP Kinase Signaling System; Metastasis; MicroRNA; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; miR-497; Neovascularization; Neovascularization, Pathologic - genetics; Neovascularization, Pathologic - metabolism; Oncology, Experimental; Ovarian cancer; ovarian carcinoma; Ovarian Neoplasms - blood supply; Ovarian Neoplasms - genetics; Ovarian Neoplasms - pathology; Patients; Physiological aspects; Proteins; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - genetics; Vascular Endothelial Growth Factor A - metabolism; VEGFA; United States > US

MicroRNAs (miRNAs) have been shown to play an important role in diverse biological processes and cancer progression. The objective of the present study was to investigate the role of miR-497 in ovarian cancer angiogenesis. We found that miR-497 expression was downregulated in human ovarian cancer ti...