Riociguat for the Treatment of Chronic Thromboembolic Pulmonary Hypertension - Ghofrani, Hossein-Ardeschir; D'Armini, Andrea M; Grimminger, Friedrich; Hoeper, Marius M; Jansa, Pavel; Kim, Nick H; Mayer, Eckhard; Simonneau, Gerald; Wilkins, Martin R; Fritsch, Arno; Neuser, Dieter; Weimann, Gerrit; et al. (The New England journal of medicine, 2013)
Keywords: Aged; Biological and medical sciences; Blood and lymphatic vessels; Brain natriuretic peptide; Cardiology. Vascular system; Chest; Chronic Disease; Clinical trials; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Double-Blind Method; Drug dosages; Dyspnea; Exercise Tolerance - drug effects; Fees & charges; Female; Functional morphology; General aspects; Guanylate cyclase; Heart; Humans; Hypertension; Hypertension, Pulmonary - drug therapy; Hypertension, Pulmonary - physiopathology; Least-Squares Analysis; Male; Medical imaging; Medical sciences; Middle Aged; Nitric oxide; Patients; Pharmaceuticals; Pneumology; Pulmonary Embolism - complications; Pulmonary hypertension; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases; Pyrazoles - adverse effects; Pyrazoles - pharmacology; Pyrazoles - therapeutic use; Pyrimidines - adverse effects; Pyrimidines - pharmacology; Pyrimidines - therapeutic use; Respiration; Right ventricular failure; Surgery; Syncope; Thromboembolism; Vascular Resistance - drug effects; Ventricle; Walking; Vascular disease; Medicine; Chronic; Treatment; Respiratory disease; Cardiovascular disease; Thromboembolism; Thrombosis; Embolism; Pulmonary hypertension