The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

• Published in: Nature reviews. Cancer Vol. 2; no. 7; pp. 489 - 501
• Main Authors: Vivanco, Igor, Sawyers, Charles L.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2002; Nature Publishing Group
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Cancer; Cancer Research; Cell Division; Cellular signal transduction; Control; Disease Models, Animal; Gene Deletion; Genetic aspects; Humans; Lipids; Mice; Models, Biological; Neoplasms - enzymology; Phenotype; Phosphatidylinositol 3-Kinases - metabolism; Phosphatidylinositol 3-Kinases - physiology; Phosphatidylinositol Phosphates - physiology; Physiological aspects; Protein Biosynthesis; Protein kinases; Protein-Serine-Threonine Kinases; Proto-Oncogene Proteins - metabolism; Proto-Oncogene Proteins c-akt; review-article; Signal Transduction; United States

Key Points The phosphatidylinositol 3-kinase (PI3K) pathway regulates various cellular processes, such as proliferation, growth, apoptosis and cytoskeletal rearrangement. PI3Ks are heterodimeric lipid kinases that are composed of a regulatory and catalytic subunit that are encoded by different genes...